Adverse effects of hyperbilirubinemia on the development of healthy term infants
Background Indirect hyperbilirubinemia is a common problem dur- ing the neonatal period and may cause long-term abnormality or developmental delay. Objective To evaluate the adverse effects of hyperbilirubinemia on the development of healthy term infants. Methods This was a prospective cohort study...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Indonesian Pediatric Society Publishing House
2016-10-01
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| Series: | Paediatrica Indonesiana |
| Subjects: | |
| Online Access: | https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/901 |
| _version_ | 1818989210024017920 |
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| author | I Made Arimbawa Soetjiningsih Soetjiningsih I K Kari |
| author_facet | I Made Arimbawa Soetjiningsih Soetjiningsih I K Kari |
| author_sort | I Made Arimbawa |
| collection | DOAJ |
| description | Background Indirect hyperbilirubinemia is a common problem dur-
ing the neonatal period and may cause long-term abnormality or
developmental delay.
Objective To evaluate the adverse effects of hyperbilirubinemia
on the development of healthy term infants.
Methods This was a prospective cohort study on healthy term
infants born in Sanglah Hospital, Denpasar. Mullen Scale Tests
were performed at the ages of 3 and 6 months to assess subjects’
development. Bivariate and multivariate analyses were conducted
to examine the relationship between several dependent variables
and developmental outcomes.
Results One hundred and twelve infants were enrolled in this study
[56 with hyperbilirubinemia, 56 without hyperbilirubinemia; 58 (52%)
male, 54 (48%) female]. Mean birth weight was 318.3 grams (SD
342.26) vs 3162.5 grams (SD 338.61). At the age of 3 months,
below average category according to Mullen Scale Test was higher
in infants with history of hyperbilirubinemia compared to those with-
out hyperbilirubinemia, which was statistically significant for fine
motor scale (17.9% vs 5.4%; respectively; P=0.039; RR 1.66; 95%
CI 1.15;2.39). At 6 months of age, it was higher in infants with
history of hyperbilirubinemia compared to those without hyperbi-
lirubinemia and this was statistically significant for gross motor scale
(19.6% vs 3.6%, respectively; RR 1.86; 95%CI 1.36; 2.56; P=0.008)
and fine motor scale (17.9% vs 5.4%, respectively; RR 1.66; 95%CI
1.15; 2.39; P=0.039). Multivariate logistic regression test showed
that only hyperbilirubinemia was correlated with gross motor scale
delay at the age of 6 months (P=0.027; OR 5.97; 95%CI 1.22;
29.12).
Conclusion Healthy term infants with history of hiperbilirubinemia
were associated with increased gross motor scale delay at the
age of 6 months |
| first_indexed | 2024-12-20T19:34:51Z |
| format | Article |
| id | doaj.art-2f41517fc5eb44db9bb9d9755080eb8e |
| institution | Directory Open Access Journal |
| issn | 0030-9311 2338-476X |
| language | English |
| last_indexed | 2024-12-20T19:34:51Z |
| publishDate | 2016-10-01 |
| publisher | Indonesian Pediatric Society Publishing House |
| record_format | Article |
| series | Paediatrica Indonesiana |
| spelling | doaj.art-2f41517fc5eb44db9bb9d9755080eb8e2022-12-21T19:28:40ZengIndonesian Pediatric Society Publishing HousePaediatrica Indonesiana0030-93112338-476X2016-10-0146251610.14238/pi46.2.2006.51-6759Adverse effects of hyperbilirubinemia on the development of healthy term infantsI Made ArimbawaSoetjiningsih SoetjiningsihI K KariBackground Indirect hyperbilirubinemia is a common problem dur- ing the neonatal period and may cause long-term abnormality or developmental delay. Objective To evaluate the adverse effects of hyperbilirubinemia on the development of healthy term infants. Methods This was a prospective cohort study on healthy term infants born in Sanglah Hospital, Denpasar. Mullen Scale Tests were performed at the ages of 3 and 6 months to assess subjects’ development. Bivariate and multivariate analyses were conducted to examine the relationship between several dependent variables and developmental outcomes. Results One hundred and twelve infants were enrolled in this study [56 with hyperbilirubinemia, 56 without hyperbilirubinemia; 58 (52%) male, 54 (48%) female]. Mean birth weight was 318.3 grams (SD 342.26) vs 3162.5 grams (SD 338.61). At the age of 3 months, below average category according to Mullen Scale Test was higher in infants with history of hyperbilirubinemia compared to those with- out hyperbilirubinemia, which was statistically significant for fine motor scale (17.9% vs 5.4%; respectively; P=0.039; RR 1.66; 95% CI 1.15;2.39). At 6 months of age, it was higher in infants with history of hyperbilirubinemia compared to those without hyperbi- lirubinemia and this was statistically significant for gross motor scale (19.6% vs 3.6%, respectively; RR 1.86; 95%CI 1.36; 2.56; P=0.008) and fine motor scale (17.9% vs 5.4%, respectively; RR 1.66; 95%CI 1.15; 2.39; P=0.039). Multivariate logistic regression test showed that only hyperbilirubinemia was correlated with gross motor scale delay at the age of 6 months (P=0.027; OR 5.97; 95%CI 1.22; 29.12). Conclusion Healthy term infants with history of hiperbilirubinemia were associated with increased gross motor scale delay at the age of 6 monthshttps://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/901healthy term infantshyperbilirubinemiagross motor scale delayMullen Test |
| spellingShingle | I Made Arimbawa Soetjiningsih Soetjiningsih I K Kari Adverse effects of hyperbilirubinemia on the development of healthy term infants Paediatrica Indonesiana healthy term infants hyperbilirubinemia gross motor scale delay Mullen Test |
| title | Adverse effects of hyperbilirubinemia on the development of healthy term infants |
| title_full | Adverse effects of hyperbilirubinemia on the development of healthy term infants |
| title_fullStr | Adverse effects of hyperbilirubinemia on the development of healthy term infants |
| title_full_unstemmed | Adverse effects of hyperbilirubinemia on the development of healthy term infants |
| title_short | Adverse effects of hyperbilirubinemia on the development of healthy term infants |
| title_sort | adverse effects of hyperbilirubinemia on the development of healthy term infants |
| topic | healthy term infants hyperbilirubinemia gross motor scale delay Mullen Test |
| url | https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/901 |
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