Maximizing binary interactome mapping with a minimal number of assays
Comprehensive mapping of binary protein-protein interactions requires to combine several complementary assays. Here, the authors show that complete coverage could be reached with a minimal number of assays as long as they explore various experimental conditions.
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2019-08-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-019-11809-2 |
| _version_ | 1818683066431832064 |
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| author | Soon Gang Choi Julien Olivet Patricia Cassonnet Pierre-Olivier Vidalain Katja Luck Luke Lambourne Kerstin Spirohn Irma Lemmens Mélanie Dos Santos Caroline Demeret Louis Jones Sudharshan Rangarajan Wenting Bian Eloi P. Coutant Yves L. Janin Sylvie van der Werf Philipp Trepte Erich E. Wanker Javier De Las Rivas Jan Tavernier Jean-Claude Twizere Tong Hao David E. Hill Marc Vidal Michael A. Calderwood Yves Jacob |
| author_facet | Soon Gang Choi Julien Olivet Patricia Cassonnet Pierre-Olivier Vidalain Katja Luck Luke Lambourne Kerstin Spirohn Irma Lemmens Mélanie Dos Santos Caroline Demeret Louis Jones Sudharshan Rangarajan Wenting Bian Eloi P. Coutant Yves L. Janin Sylvie van der Werf Philipp Trepte Erich E. Wanker Javier De Las Rivas Jan Tavernier Jean-Claude Twizere Tong Hao David E. Hill Marc Vidal Michael A. Calderwood Yves Jacob |
| author_sort | Soon Gang Choi |
| collection | DOAJ |
| description | Comprehensive mapping of binary protein-protein interactions requires to combine several complementary assays. Here, the authors show that complete coverage could be reached with a minimal number of assays as long as they explore various experimental conditions. |
| first_indexed | 2024-12-17T10:28:50Z |
| format | Article |
| id | doaj.art-2f419fab78844c44ac0e5edf56d0f33d |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-17T10:28:50Z |
| publishDate | 2019-08-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-2f419fab78844c44ac0e5edf56d0f33d2022-12-21T21:52:34ZengNature PortfolioNature Communications2041-17232019-08-0110111310.1038/s41467-019-11809-2Maximizing binary interactome mapping with a minimal number of assaysSoon Gang Choi0Julien Olivet1Patricia Cassonnet2Pierre-Olivier Vidalain3Katja Luck4Luke Lambourne5Kerstin Spirohn6Irma Lemmens7Mélanie Dos Santos8Caroline Demeret9Louis Jones10Sudharshan Rangarajan11Wenting Bian12Eloi P. Coutant13Yves L. Janin14Sylvie van der Werf15Philipp Trepte16Erich E. Wanker17Javier De Las Rivas18Jan Tavernier19Jean-Claude Twizere20Tong Hao21David E. Hill22Marc Vidal23Michael A. Calderwood24Yves Jacob25Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute (DFCI)Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute (DFCI)Département de Virologie, Unité de Génétique Moléculaire des Virus à ARN (GMVR), Institut Pasteur, UMR3569, Centre National de la Recherche Scientifique (CNRS), Université Paris Diderot, Sorbonne Paris CitéÉquipe Chimie, Biologie, Modélisation et Immunologie pour la Thérapie (CBMIT), Laboratoire de Chimie et Biochimie Pharmacologiques et Toxicologiques (LCBPT), Centre Interdisciplinaire Chimie Biologie-Paris (CICB-Paris), UMR8601, CNRS, Université Paris DescartesCenter for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute (DFCI)Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute (DFCI)Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute (DFCI)Center for Medical Biotechnology, Vlaams Instituut voor Biotechnologie (VIB)Département de Virologie, Unité de Génétique Moléculaire des Virus à ARN (GMVR), Institut Pasteur, UMR3569, Centre National de la Recherche Scientifique (CNRS), Université Paris Diderot, Sorbonne Paris CitéDépartement de Virologie, Unité de Génétique Moléculaire des Virus à ARN (GMVR), Institut Pasteur, UMR3569, Centre National de la Recherche Scientifique (CNRS), Université Paris Diderot, Sorbonne Paris CitéCentre de Bioinformatique, Biostatistique et Biologie Intégrative (C3BI), Institut PasteurCenter for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute (DFCI)Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute (DFCI)Département de Biologie Structurale et Chimie, Unité de Chimie et Biocatalyse, Institut Pasteur, UMR3523, CNRSDépartement de Biologie Structurale et Chimie, Unité de Chimie et Biocatalyse, Institut Pasteur, UMR3523, CNRSDépartement de Virologie, Unité de Génétique Moléculaire des Virus à ARN (GMVR), Institut Pasteur, UMR3569, Centre National de la Recherche Scientifique (CNRS), Université Paris Diderot, Sorbonne Paris CitéNeuroproteomics, Max Delbrück Center for Molecular MedicineNeuroproteomics, Max Delbrück Center for Molecular MedicineCancer Research Center (CiC-IBMCC, CSIC/USAL), Consejo Superior de Investigaciones Científicas (CSIC), University of Salamanca (USAL), Campus Miguel de UnamunoCenter for Medical Biotechnology, Vlaams Instituut voor Biotechnologie (VIB)Laboratory of Viral Interactomes, Unit of Molecular Biology of Diseases, Groupe Interdisciplinaire de Génomique Appliquée (GIGA Institute), University of LiègeCenter for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute (DFCI)Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute (DFCI)Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute (DFCI)Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute (DFCI)Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute (DFCI)Comprehensive mapping of binary protein-protein interactions requires to combine several complementary assays. Here, the authors show that complete coverage could be reached with a minimal number of assays as long as they explore various experimental conditions.https://doi.org/10.1038/s41467-019-11809-2 |
| spellingShingle | Soon Gang Choi Julien Olivet Patricia Cassonnet Pierre-Olivier Vidalain Katja Luck Luke Lambourne Kerstin Spirohn Irma Lemmens Mélanie Dos Santos Caroline Demeret Louis Jones Sudharshan Rangarajan Wenting Bian Eloi P. Coutant Yves L. Janin Sylvie van der Werf Philipp Trepte Erich E. Wanker Javier De Las Rivas Jan Tavernier Jean-Claude Twizere Tong Hao David E. Hill Marc Vidal Michael A. Calderwood Yves Jacob Maximizing binary interactome mapping with a minimal number of assays Nature Communications |
| title | Maximizing binary interactome mapping with a minimal number of assays |
| title_full | Maximizing binary interactome mapping with a minimal number of assays |
| title_fullStr | Maximizing binary interactome mapping with a minimal number of assays |
| title_full_unstemmed | Maximizing binary interactome mapping with a minimal number of assays |
| title_short | Maximizing binary interactome mapping with a minimal number of assays |
| title_sort | maximizing binary interactome mapping with a minimal number of assays |
| url | https://doi.org/10.1038/s41467-019-11809-2 |
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