Mast cell in infantile hemangioma
Infantile hemangioma (IH) is the most common benign vascular tumor characterized by three phases — proliferation, early involution and late involution. Mast cells (MCs) play an important role in allergic reactions and numerous diseases, including tumors. While the mechanisms underlying MCs migration...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-01-01
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| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2024.1304478/full |
| _version_ | 1827378793349644288 |
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| author | Meng Xia Wenying Liu Fang Hou |
| author_facet | Meng Xia Wenying Liu Fang Hou |
| author_sort | Meng Xia |
| collection | DOAJ |
| description | Infantile hemangioma (IH) is the most common benign vascular tumor characterized by three phases — proliferation, early involution and late involution. Mast cells (MCs) play an important role in allergic reactions and numerous diseases, including tumors. While the mechanisms underlying MCs migration, activation and function in the life cycle of IH remain unclear, previous studies suggested that MCs circulate through the vasculature and migrate into IH, and subsequently mature and get activated. Estradiol (E2) emerges as a potential attractant for MC migration into IH and their subsequent activation. In various stages of IH, activated MCs secrete both proangiogenic and anti-angiogenic modulators, absorbed by various cells adjacent to them. Imbalances in these modulators may contribute to IH proliferation and involution. |
| first_indexed | 2024-03-08T13:02:59Z |
| format | Article |
| id | doaj.art-2f449d3a07a543e6b5dbd544b95babe2 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-03-08T13:02:59Z |
| publishDate | 2024-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-2f449d3a07a543e6b5dbd544b95babe22024-01-19T04:19:09ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2024-01-011410.3389/fonc.2024.13044781304478Mast cell in infantile hemangiomaMeng XiaWenying LiuFang HouInfantile hemangioma (IH) is the most common benign vascular tumor characterized by three phases — proliferation, early involution and late involution. Mast cells (MCs) play an important role in allergic reactions and numerous diseases, including tumors. While the mechanisms underlying MCs migration, activation and function in the life cycle of IH remain unclear, previous studies suggested that MCs circulate through the vasculature and migrate into IH, and subsequently mature and get activated. Estradiol (E2) emerges as a potential attractant for MC migration into IH and their subsequent activation. In various stages of IH, activated MCs secrete both proangiogenic and anti-angiogenic modulators, absorbed by various cells adjacent to them. Imbalances in these modulators may contribute to IH proliferation and involution.https://www.frontiersin.org/articles/10.3389/fonc.2024.1304478/fullinfantile hemangiomamast cellestradiolproangiogenesisanti-angiogenesis |
| spellingShingle | Meng Xia Wenying Liu Fang Hou Mast cell in infantile hemangioma Frontiers in Oncology infantile hemangioma mast cell estradiol proangiogenesis anti-angiogenesis |
| title | Mast cell in infantile hemangioma |
| title_full | Mast cell in infantile hemangioma |
| title_fullStr | Mast cell in infantile hemangioma |
| title_full_unstemmed | Mast cell in infantile hemangioma |
| title_short | Mast cell in infantile hemangioma |
| title_sort | mast cell in infantile hemangioma |
| topic | infantile hemangioma mast cell estradiol proangiogenesis anti-angiogenesis |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2024.1304478/full |
| work_keys_str_mv | AT mengxia mastcellininfantilehemangioma AT wenyingliu mastcellininfantilehemangioma AT fanghou mastcellininfantilehemangioma |