Acylcarnitine Profiles in Acetaminophen Toxicity in the Mouse: Comparison to Toxicity, Metabolism and Hepatocyte Regeneration

Acylcarnitine Profiles in Acetaminophen Toxicity in the Mouse: Comparison to Toxicity, Metabolism and Hepatocyte Regeneration

High doses of acetaminophen (APAP) result in hepatotoxicity that involves metabolic activation of the parent compound, covalent binding of the reactive intermediate N-acetyl-p-benzoquinone imine (NAPQI) to liver proteins, and depletion of hepatic glutathione. Impaired fatty acid β-oxidation has been...

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Bibliographic Details
Main Authors: Jack Hinson, Laura James, Pippa Simpson, Leah Hennings, Ke Yan, Sandra McCullough, Shubhra Chaudhuri, Richard Beger, Lisa Pence, Sudeepa Bhattacharyya
Format: Article
Language:English
Published: MDPI AG 2013-08-01
Series:Metabolites
Subjects:
acetaminophen
hepatic
β-oxidation
toxicity
acylcarnitine
Online Access:http://www.mdpi.com/2218-1989/3/3/606

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