LncRNA ELF3-AS1 inhibits gastric cancer by forming a negative feedback loop with SNAI2 and regulates ELF3 mRNA stability via interacting with ILF2/ILF3 complex

LncRNA ELF3-AS1 inhibits gastric cancer by forming a negative feedback loop with SNAI2 and regulates ELF3 mRNA stability via interacting with ILF2/ILF3 complex

Abstract Background The biological function of lncRNA ELF3-AS1 remains largely unknown in cancers. The cause of SNAI2 overexpression in tumor metastasis remains largely unclear. The molecular mechanisms underlying the high co-expression of antisense lncRNAs and adjacent protein-coding genes remains...

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Bibliographic Details
Main Authors: Dandan Li, Li Shen, Xudong Zhang, Zhen Chen, Pan Huang, Congcong Huang, Shanshan Qin
Format: Article
Language:English
Published: BMC 2022-12-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
ELF3-AS1
SNAI2 overexpression
Transcriptional regulation
mRNA stability
Gastric cancer metastasis
Online Access:https://doi.org/10.1186/s13046-022-02541-9

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