The Importance of Breast Adipose Tissue in Breast Cancer
Adipose tissue is a complex endocrine organ, with a role in obesity and cancer. Adipose tissue is generally linked to excessive body fat, and it is well known that the female breast is rich in adipose tissue. Hence, one can wonder: what is the role of adipose tissue in the breast and why is it requi...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-08-01
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| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/21/16/5760 |
| _version_ | 1797558855729676288 |
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| author | Charu Kothari Caroline Diorio Francine Durocher |
| author_facet | Charu Kothari Caroline Diorio Francine Durocher |
| author_sort | Charu Kothari |
| collection | DOAJ |
| description | Adipose tissue is a complex endocrine organ, with a role in obesity and cancer. Adipose tissue is generally linked to excessive body fat, and it is well known that the female breast is rich in adipose tissue. Hence, one can wonder: what is the role of adipose tissue in the breast and why is it required? Adipose tissue as an organ consists of adipocytes, an extracellular matrix (ECM) and immune cells, with a significant role in the dynamics of breast changes throughout the life span of a female breast from puberty, pregnancy, lactation and involution. In this review, we will discuss the importance of breast adipose tissue in breast development and its involvement in breast changes happening during pregnancy, lactation and involution. We will focus on understanding the biology of breast adipose tissue, with an overview on its involvement in the various steps of breast cancer development and progression. The interaction between the breast adipose tissue surrounding cancer cells and vice-versa modifies the tumor microenvironment in favor of cancer. Understanding this mutual interaction and the role of breast adipose tissue in the tumor microenvironment could potentially raise the possibility of overcoming breast adipose tissue mediated resistance to therapies and finding novel candidates to target breast cancer. |
| first_indexed | 2024-03-10T17:37:16Z |
| format | Article |
| id | doaj.art-2f46c7b2fbc4485ab02335cf70f1e11c |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T17:37:16Z |
| publishDate | 2020-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-2f46c7b2fbc4485ab02335cf70f1e11c2023-11-20T09:49:01ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672020-08-012116576010.3390/ijms21165760The Importance of Breast Adipose Tissue in Breast CancerCharu Kothari0Caroline Diorio1Francine Durocher2Department of Molecular Medicine, Faculty of Medicine, Laval University, Quebec, QC G1T 1C2, CanadaCancer Research Centre, CHU de Quebec Research Centre, Quebec, QC G1V 4G2, CanadaDepartment of Molecular Medicine, Faculty of Medicine, Laval University, Quebec, QC G1T 1C2, CanadaAdipose tissue is a complex endocrine organ, with a role in obesity and cancer. Adipose tissue is generally linked to excessive body fat, and it is well known that the female breast is rich in adipose tissue. Hence, one can wonder: what is the role of adipose tissue in the breast and why is it required? Adipose tissue as an organ consists of adipocytes, an extracellular matrix (ECM) and immune cells, with a significant role in the dynamics of breast changes throughout the life span of a female breast from puberty, pregnancy, lactation and involution. In this review, we will discuss the importance of breast adipose tissue in breast development and its involvement in breast changes happening during pregnancy, lactation and involution. We will focus on understanding the biology of breast adipose tissue, with an overview on its involvement in the various steps of breast cancer development and progression. The interaction between the breast adipose tissue surrounding cancer cells and vice-versa modifies the tumor microenvironment in favor of cancer. Understanding this mutual interaction and the role of breast adipose tissue in the tumor microenvironment could potentially raise the possibility of overcoming breast adipose tissue mediated resistance to therapies and finding novel candidates to target breast cancer.https://www.mdpi.com/1422-0067/21/16/5760breast developmentbreast cancerbreast adipose tissuerisk factorstherapeutic intervention |
| spellingShingle | Charu Kothari Caroline Diorio Francine Durocher The Importance of Breast Adipose Tissue in Breast Cancer International Journal of Molecular Sciences breast development breast cancer breast adipose tissue risk factors therapeutic intervention |
| title | The Importance of Breast Adipose Tissue in Breast Cancer |
| title_full | The Importance of Breast Adipose Tissue in Breast Cancer |
| title_fullStr | The Importance of Breast Adipose Tissue in Breast Cancer |
| title_full_unstemmed | The Importance of Breast Adipose Tissue in Breast Cancer |
| title_short | The Importance of Breast Adipose Tissue in Breast Cancer |
| title_sort | importance of breast adipose tissue in breast cancer |
| topic | breast development breast cancer breast adipose tissue risk factors therapeutic intervention |
| url | https://www.mdpi.com/1422-0067/21/16/5760 |
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