Insights into Dyslexia Genetics Research from the Last Two Decades
Dyslexia, a specific reading disability, is a common (up to 10% of children) and highly heritable (~70%) neurodevelopmental disorder. Behavioral and molecular genetic approaches are aimed towards dissecting its significant genetic component. In the proposed review, we will summarize advances in twin...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-12-01
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| Series: | Brain Sciences |
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| Online Access: | https://www.mdpi.com/2076-3425/12/1/27 |
| _version_ | 1797495383000088576 |
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| author | Florina Erbeli Marianne Rice Silvia Paracchini |
| author_facet | Florina Erbeli Marianne Rice Silvia Paracchini |
| author_sort | Florina Erbeli |
| collection | DOAJ |
| description | Dyslexia, a specific reading disability, is a common (up to 10% of children) and highly heritable (~70%) neurodevelopmental disorder. Behavioral and molecular genetic approaches are aimed towards dissecting its significant genetic component. In the proposed review, we will summarize advances in twin and molecular genetic research from the past 20 years. First, we will briefly outline the clinical and educational presentation and epidemiology of dyslexia. Next, we will summarize results from twin studies, followed by molecular genetic research (e.g., genome-wide association studies (GWASs)). In particular, we will highlight converging key insights from genetic research. (1) Dyslexia is a highly polygenic neurodevelopmental disorder with a complex genetic architecture. (2) Dyslexia categories share a large proportion of genetics with continuously distributed measures of reading skills, with shared genetic risks also seen across development. (3) Dyslexia genetic risks are shared with those implicated in many other neurodevelopmental disorders (e.g., developmental language disorder and dyscalculia). Finally, we will discuss the implications and future directions. As the diversity of genetic studies continues to increase through international collaborate efforts, we will highlight the challenges in advances of genetics discoveries in this field. |
| first_indexed | 2024-03-10T01:48:50Z |
| format | Article |
| id | doaj.art-2f489852c73e4df69fe581bf2d60e563 |
| institution | Directory Open Access Journal |
| issn | 2076-3425 |
| language | English |
| last_indexed | 2024-03-10T01:48:50Z |
| publishDate | 2021-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Brain Sciences |
| spelling | doaj.art-2f489852c73e4df69fe581bf2d60e5632023-11-23T13:08:57ZengMDPI AGBrain Sciences2076-34252021-12-011212710.3390/brainsci12010027Insights into Dyslexia Genetics Research from the Last Two DecadesFlorina Erbeli0Marianne Rice1Silvia Paracchini2Department of Educational Psychology, Texas A&M University, College Station, TX 77843, USADepartment of Educational Psychology, Texas A&M University, College Station, TX 77843, USASchool of Medicine, University of St Andrews, St Andrews KY16 9AJ, UKDyslexia, a specific reading disability, is a common (up to 10% of children) and highly heritable (~70%) neurodevelopmental disorder. Behavioral and molecular genetic approaches are aimed towards dissecting its significant genetic component. In the proposed review, we will summarize advances in twin and molecular genetic research from the past 20 years. First, we will briefly outline the clinical and educational presentation and epidemiology of dyslexia. Next, we will summarize results from twin studies, followed by molecular genetic research (e.g., genome-wide association studies (GWASs)). In particular, we will highlight converging key insights from genetic research. (1) Dyslexia is a highly polygenic neurodevelopmental disorder with a complex genetic architecture. (2) Dyslexia categories share a large proportion of genetics with continuously distributed measures of reading skills, with shared genetic risks also seen across development. (3) Dyslexia genetic risks are shared with those implicated in many other neurodevelopmental disorders (e.g., developmental language disorder and dyscalculia). Finally, we will discuss the implications and future directions. As the diversity of genetic studies continues to increase through international collaborate efforts, we will highlight the challenges in advances of genetics discoveries in this field.https://www.mdpi.com/2076-3425/12/1/27dyslexiageneticstwin studiesmolecular genetic studies |
| spellingShingle | Florina Erbeli Marianne Rice Silvia Paracchini Insights into Dyslexia Genetics Research from the Last Two Decades Brain Sciences dyslexia genetics twin studies molecular genetic studies |
| title | Insights into Dyslexia Genetics Research from the Last Two Decades |
| title_full | Insights into Dyslexia Genetics Research from the Last Two Decades |
| title_fullStr | Insights into Dyslexia Genetics Research from the Last Two Decades |
| title_full_unstemmed | Insights into Dyslexia Genetics Research from the Last Two Decades |
| title_short | Insights into Dyslexia Genetics Research from the Last Two Decades |
| title_sort | insights into dyslexia genetics research from the last two decades |
| topic | dyslexia genetics twin studies molecular genetic studies |
| url | https://www.mdpi.com/2076-3425/12/1/27 |
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