Leveraging mechanobiology and biophysical cues in lung organoids for studying lung development and disease
Lung organoids have emerged as powerful tools for studying lung distal diseases by recapitulating the cellular diversity and microenvironment of the lung tissue. This review article highlights the advancements in leveraging mechanobiology and biophysical cues in lung organoid engineering to improve...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-10-01
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| Series: | Frontiers in Chemical Engineering |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fceng.2023.1255783/full |
| _version_ | 1797652083641417728 |
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| author | Ziming Shao Paolo De Coppi Paolo De Coppi Federica Michielin |
| author_facet | Ziming Shao Paolo De Coppi Paolo De Coppi Federica Michielin |
| author_sort | Ziming Shao |
| collection | DOAJ |
| description | Lung organoids have emerged as powerful tools for studying lung distal diseases by recapitulating the cellular diversity and microenvironment of the lung tissue. This review article highlights the advancements in leveraging mechanobiology and biophysical cues in lung organoid engineering to improve their physiological relevance and disease modelling capabilities. We discuss the role of mechanobiology in lung development and homeostasis, as well as the integration of biophysical cues in the design and culture of lung organoids. Furthermore, we explore how these advancements have contributed to the understanding of lung distal diseases pathogenesis. We also discuss the challenges and future directions in harnessing mechanobiology and biophysical cues in lung organoid research. This review showcases the potential of lung organoids as a platform to investigate the underappreciated impacts of biophysical and biomechanical properties in enhancing lung organoids complexity and functionality, and ultimately provide new insight into embryonic lung development and pulmonary distal diseases pathogenesis. |
| first_indexed | 2024-03-11T16:24:55Z |
| format | Article |
| id | doaj.art-2f4ade9450904e9eb7748889bbfcca4a |
| institution | Directory Open Access Journal |
| issn | 2673-2718 |
| language | English |
| last_indexed | 2024-03-11T16:24:55Z |
| publishDate | 2023-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Chemical Engineering |
| spelling | doaj.art-2f4ade9450904e9eb7748889bbfcca4a2023-10-24T13:10:33ZengFrontiers Media S.A.Frontiers in Chemical Engineering2673-27182023-10-01510.3389/fceng.2023.12557831255783Leveraging mechanobiology and biophysical cues in lung organoids for studying lung development and diseaseZiming Shao0Paolo De Coppi1Paolo De Coppi2Federica Michielin3Stem Cells and Regenerative Medicine Section, Developmental Biology and Cancer Department, UCL Great Ormond Street Institute of Child Health, University College London, London, United KingdomStem Cells and Regenerative Medicine Section, Developmental Biology and Cancer Department, UCL Great Ormond Street Institute of Child Health, University College London, London, United KingdomGreat Ormond Street Hospital (GOSH), London, United KingdomStem Cells and Regenerative Medicine Section, Developmental Biology and Cancer Department, UCL Great Ormond Street Institute of Child Health, University College London, London, United KingdomLung organoids have emerged as powerful tools for studying lung distal diseases by recapitulating the cellular diversity and microenvironment of the lung tissue. This review article highlights the advancements in leveraging mechanobiology and biophysical cues in lung organoid engineering to improve their physiological relevance and disease modelling capabilities. We discuss the role of mechanobiology in lung development and homeostasis, as well as the integration of biophysical cues in the design and culture of lung organoids. Furthermore, we explore how these advancements have contributed to the understanding of lung distal diseases pathogenesis. We also discuss the challenges and future directions in harnessing mechanobiology and biophysical cues in lung organoid research. This review showcases the potential of lung organoids as a platform to investigate the underappreciated impacts of biophysical and biomechanical properties in enhancing lung organoids complexity and functionality, and ultimately provide new insight into embryonic lung development and pulmonary distal diseases pathogenesis.https://www.frontiersin.org/articles/10.3389/fceng.2023.1255783/fulllung organoidsmechanobiologybiophysical cueslung distal diseasesdisease modelling |
| spellingShingle | Ziming Shao Paolo De Coppi Paolo De Coppi Federica Michielin Leveraging mechanobiology and biophysical cues in lung organoids for studying lung development and disease Frontiers in Chemical Engineering lung organoids mechanobiology biophysical cues lung distal diseases disease modelling |
| title | Leveraging mechanobiology and biophysical cues in lung organoids for studying lung development and disease |
| title_full | Leveraging mechanobiology and biophysical cues in lung organoids for studying lung development and disease |
| title_fullStr | Leveraging mechanobiology and biophysical cues in lung organoids for studying lung development and disease |
| title_full_unstemmed | Leveraging mechanobiology and biophysical cues in lung organoids for studying lung development and disease |
| title_short | Leveraging mechanobiology and biophysical cues in lung organoids for studying lung development and disease |
| title_sort | leveraging mechanobiology and biophysical cues in lung organoids for studying lung development and disease |
| topic | lung organoids mechanobiology biophysical cues lung distal diseases disease modelling |
| url | https://www.frontiersin.org/articles/10.3389/fceng.2023.1255783/full |
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