Overview on the Different Patterns of Tumor Vascularization
Angiogenesis is a crucial event in the physiological processes of embryogenesis and wound healing. During malignant transformation, dysregulation of angiogenesis leads to the formation of a vascular network of tumor-associated capillaries promoting survival and proliferation of the tumor cells. Star...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-03-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/10/3/639 |
| _version_ | 1797541451765121024 |
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| author | Domenico Ribatti Francesco Pezzella |
| author_facet | Domenico Ribatti Francesco Pezzella |
| author_sort | Domenico Ribatti |
| collection | DOAJ |
| description | Angiogenesis is a crucial event in the physiological processes of embryogenesis and wound healing. During malignant transformation, dysregulation of angiogenesis leads to the formation of a vascular network of tumor-associated capillaries promoting survival and proliferation of the tumor cells. Starting with the hypothesis formulated by Judah Folkman that tumor growth is angiogenesis-dependent, this area of research has a solid scientific foundation and inhibition of angiogenesis is a major area of therapeutic development for the treatment of cancer. Over this period numerous authors published data of vascularization of tumors, which attributed the cause of neo-vascularization to various factors including inflammation, release of angiogenic cytokines, vasodilatation, and increased tumor metabolism. More recently, it has been demonstrated that tumor vasculature is not necessarily derived by endothelial cell proliferation and sprouting of new capillaries, but alternative vascularization mechanisms have been described, namely vascular co-option and vasculogenic mimicry. In this article, we have analyzed the mechanisms involved in tumor vascularization in association with classical angiogenesis, including post-natal vasculogenesis, intussusceptive microvascular growth, vascular co-option, and vasculogenic mimicry. We have also discussed the role of these alternative mechanism in resistance to anti-angiogenic therapy and potential therapeutic approaches to overcome resistance. |
| first_indexed | 2024-03-10T13:16:13Z |
| format | Article |
| id | doaj.art-2f4aec5e44644b048aeefd8ce86c1854 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T13:16:13Z |
| publishDate | 2021-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-2f4aec5e44644b048aeefd8ce86c18542023-11-21T10:22:15ZengMDPI AGCells2073-44092021-03-0110363910.3390/cells10030639Overview on the Different Patterns of Tumor VascularizationDomenico Ribatti0Francesco Pezzella1Department of Basic Medical Sciences, Neurosciences and Sensory Organs, University of Bari Medical School, 70124 Bari, ItalyNuffield Division of Laboratory Science, Radcliffe Department of Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX39DU, UKAngiogenesis is a crucial event in the physiological processes of embryogenesis and wound healing. During malignant transformation, dysregulation of angiogenesis leads to the formation of a vascular network of tumor-associated capillaries promoting survival and proliferation of the tumor cells. Starting with the hypothesis formulated by Judah Folkman that tumor growth is angiogenesis-dependent, this area of research has a solid scientific foundation and inhibition of angiogenesis is a major area of therapeutic development for the treatment of cancer. Over this period numerous authors published data of vascularization of tumors, which attributed the cause of neo-vascularization to various factors including inflammation, release of angiogenic cytokines, vasodilatation, and increased tumor metabolism. More recently, it has been demonstrated that tumor vasculature is not necessarily derived by endothelial cell proliferation and sprouting of new capillaries, but alternative vascularization mechanisms have been described, namely vascular co-option and vasculogenic mimicry. In this article, we have analyzed the mechanisms involved in tumor vascularization in association with classical angiogenesis, including post-natal vasculogenesis, intussusceptive microvascular growth, vascular co-option, and vasculogenic mimicry. We have also discussed the role of these alternative mechanism in resistance to anti-angiogenic therapy and potential therapeutic approaches to overcome resistance.https://www.mdpi.com/2073-4409/10/3/639angiogenesistumor growthvascular co-optionvasculogenic mimicry |
| spellingShingle | Domenico Ribatti Francesco Pezzella Overview on the Different Patterns of Tumor Vascularization Cells angiogenesis tumor growth vascular co-option vasculogenic mimicry |
| title | Overview on the Different Patterns of Tumor Vascularization |
| title_full | Overview on the Different Patterns of Tumor Vascularization |
| title_fullStr | Overview on the Different Patterns of Tumor Vascularization |
| title_full_unstemmed | Overview on the Different Patterns of Tumor Vascularization |
| title_short | Overview on the Different Patterns of Tumor Vascularization |
| title_sort | overview on the different patterns of tumor vascularization |
| topic | angiogenesis tumor growth vascular co-option vasculogenic mimicry |
| url | https://www.mdpi.com/2073-4409/10/3/639 |
| work_keys_str_mv | AT domenicoribatti overviewonthedifferentpatternsoftumorvascularization AT francescopezzella overviewonthedifferentpatternsoftumorvascularization |