Dual pH/redox-responsive hyperbranched polymeric nanocarriers with TME-trigger size shrinkage and charge reversible ability for amplified chemotherapy of breast cancer

Dual pH/redox-responsive hyperbranched polymeric nanocarriers with TME-trigger size shrinkage and charge reversible ability for amplified chemotherapy of breast cancer

Abstract A novel pH/redox-responsive hyperbranched MeO-PEG-b-(NIPAAm-co-PBAE) nanoparticles (NPs) were designed with size shrinkage and charge-reversible potential for targeted delivery of docetaxel (DTX) to MDA-MB-231 cell lines. In the tumor microenvironment (TME), amine protonation induces charge...

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Bibliographic Details
Main Authors: Fahimeh Badparvar, Ahmad Poursattar Marjani, Roya Salehi, Fatemeh Ramezani
Format: Article
Language:English
Published: Nature Portfolio 2024-04-01
Series:Scientific Reports
Subjects:
Nano drug delivery systems (NDDSs)
pH/redox dual-responsive
Copolymeric nanoparticles
Tumor microenvironment (TME)
Online Access:https://doi.org/10.1038/s41598-024-57296-4

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