HOMA estimated insulin resistance as a marker for angiographic severity of coronary artery disease in non-diabetic and non-obese patients
Background: Insulin resistance (IR) examined by homeostasis model assessment of insulin resistance (HOMA-IR) measures increased carotid atherosclerosis risks in non-diabetic and non-obese persons. The information about the relationship between IR and coronary atherosclerosis severity among non-diabe...
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| Format: | Article |
| Language: | English |
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Babol University of Medical Sciences
2023-05-01
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| Series: | Caspian Journal of Internal Medicine |
| Subjects: | |
| Online Access: | http://caspjim.com/article-1-3452-en.pdf |
| _version_ | 1797788303909453824 |
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| author | Mohamed Eid Sherif A. Sayed Nayel A. Zaki Amera M. F. Hamdy Ali M. A. Altaher |
| author_facet | Mohamed Eid Sherif A. Sayed Nayel A. Zaki Amera M. F. Hamdy Ali M. A. Altaher |
| author_sort | Mohamed Eid |
| collection | DOAJ |
| description | Background: Insulin resistance (IR) examined by homeostasis model assessment of insulin resistance (HOMA-IR) measures increased carotid atherosclerosis risks in non-diabetic and non-obese persons. The information about the relationship between IR and coronary atherosclerosis severity among non-diabetic and non- obese population showed conflicting results. The goal of the current study was to assess the relationship that links IR and coronary artery disease (CAD) among non-diabetic and non-obese Egyptian populations.
Methods: 112 non-diabetic and non-obese patients were included in this study. These patients underwent coronary angiogram (CA) either due to acute coronary syndrome (ACS) or chronic stable angina with positive exercise tests.
Results: Our study found a strong association between HOMA-IR and Gensini score (r = 0.831, with p<0.001) in general population. The HOMA-IR was the most influential independent predictor for the presence of extensive coronary atherosclerosis. Non-diabetic and non-obese people carrying the risk of developing the three-vessel disease (3VD) may be identified with a HOMA-IR score of over 5.9 according to the ROC curve analysis with a sensitivity of 67.7%.
Conclusion: IR that developes in non-diabetic non-obese individuals coincides with more severe and more outspread CAD. In non-diabetic non-obese populations who need a CA, a single HOMA-IR value is higher than 5.9 may imply an elevated risk for clinically significant CAD. As insulin resistance is a reversible process, risk stratifications of CAD in non-diabetic non-obese populations could include HOMA-IR as one of its parameters. |
| first_indexed | 2024-03-13T01:34:39Z |
| format | Article |
| id | doaj.art-2f4c67602d584e649afb2204cfab3f8a |
| institution | Directory Open Access Journal |
| issn | 2008-6164 2008-6172 |
| language | English |
| last_indexed | 2024-03-13T01:34:39Z |
| publishDate | 2023-05-01 |
| publisher | Babol University of Medical Sciences |
| record_format | Article |
| series | Caspian Journal of Internal Medicine |
| spelling | doaj.art-2f4c67602d584e649afb2204cfab3f8a2023-07-04T05:13:29ZengBabol University of Medical SciencesCaspian Journal of Internal Medicine2008-61642008-61722023-05-01143495506HOMA estimated insulin resistance as a marker for angiographic severity of coronary artery disease in non-diabetic and non-obese patientsMohamed Eid0Sherif A. Sayed1Nayel A. Zaki2Amera M. F. Hamdy3Ali M. A. Altaher4 Department of Internal Medicine, Faculty of Medicine, Sohag University, Sohag, Egypt Department of Clinical Pathology, Faculty of Medicine, Sohag University, Sohag, Egypt Department of Internal Medicine, Faculty of Medicine, Sohag University, Sohag, Egypt Department of Medical Biochemistry, Faculty of Medicine, Sohag University, Sohag, Egypt Department of Internal Medicine, Faculty of Medicine, Sohag University, Sohag, Egypt. Background: Insulin resistance (IR) examined by homeostasis model assessment of insulin resistance (HOMA-IR) measures increased carotid atherosclerosis risks in non-diabetic and non-obese persons. The information about the relationship between IR and coronary atherosclerosis severity among non-diabetic and non- obese population showed conflicting results. The goal of the current study was to assess the relationship that links IR and coronary artery disease (CAD) among non-diabetic and non-obese Egyptian populations. Methods: 112 non-diabetic and non-obese patients were included in this study. These patients underwent coronary angiogram (CA) either due to acute coronary syndrome (ACS) or chronic stable angina with positive exercise tests. Results: Our study found a strong association between HOMA-IR and Gensini score (r = 0.831, with p<0.001) in general population. The HOMA-IR was the most influential independent predictor for the presence of extensive coronary atherosclerosis. Non-diabetic and non-obese people carrying the risk of developing the three-vessel disease (3VD) may be identified with a HOMA-IR score of over 5.9 according to the ROC curve analysis with a sensitivity of 67.7%. Conclusion: IR that developes in non-diabetic non-obese individuals coincides with more severe and more outspread CAD. In non-diabetic non-obese populations who need a CA, a single HOMA-IR value is higher than 5.9 may imply an elevated risk for clinically significant CAD. As insulin resistance is a reversible process, risk stratifications of CAD in non-diabetic non-obese populations could include HOMA-IR as one of its parameters.http://caspjim.com/article-1-3452-en.pdfcoronary artery diseasecoronary atherosclerosishoma estimated insulin resistance. |
| spellingShingle | Mohamed Eid Sherif A. Sayed Nayel A. Zaki Amera M. F. Hamdy Ali M. A. Altaher HOMA estimated insulin resistance as a marker for angiographic severity of coronary artery disease in non-diabetic and non-obese patients Caspian Journal of Internal Medicine coronary artery disease coronary atherosclerosis homa estimated insulin resistance. |
| title | HOMA estimated insulin resistance as a marker for angiographic severity of coronary artery disease in
non-diabetic and non-obese patients |
| title_full | HOMA estimated insulin resistance as a marker for angiographic severity of coronary artery disease in
non-diabetic and non-obese patients |
| title_fullStr | HOMA estimated insulin resistance as a marker for angiographic severity of coronary artery disease in
non-diabetic and non-obese patients |
| title_full_unstemmed | HOMA estimated insulin resistance as a marker for angiographic severity of coronary artery disease in
non-diabetic and non-obese patients |
| title_short | HOMA estimated insulin resistance as a marker for angiographic severity of coronary artery disease in
non-diabetic and non-obese patients |
| title_sort | homa estimated insulin resistance as a marker for angiographic severity of coronary artery disease in non diabetic and non obese patients |
| topic | coronary artery disease coronary atherosclerosis homa estimated insulin resistance. |
| url | http://caspjim.com/article-1-3452-en.pdf |
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