Protective Effects of N-Acetyl-L-cystein on 3,4-Methylene Dioxymethamphetamie-Induced Neurotoxicity in Cerebellum of Male Rats
Introduction: 3-4, methylenedioxymethamphetamine (MDMA) causes apoptosis in nervous system and several studies suggest that oxidative stress contributes to MDMA-induced neurotoxicity. The aim of this study is to examine the effects of N-acetyl-L-Cystein (NAC) as an antioxidant on MDMA-induced apopto...
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| Format: | Article |
| Language: | English |
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Iran University of Medical Sciences
2011-10-01
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| Series: | Basic and Clinical Neuroscience |
| Subjects: | |
| Online Access: | http://bcn.iums.ac.ir/browse.php?a_code=A-10-1-90&slc_lang=en&sid=1 |
| _version_ | 1797283084257722368 |
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| author | Sara Soleimani Asl Peiman Falahati Nima shekar riz Nima Molavi Farzaneh Esmaeili Zahra Azimi Freidoon Sajadi Parisa Hayat Alireza Samzadeh-Kermani Mehdi Mehdizadeh |
| author_facet | Sara Soleimani Asl Peiman Falahati Nima shekar riz Nima Molavi Farzaneh Esmaeili Zahra Azimi Freidoon Sajadi Parisa Hayat Alireza Samzadeh-Kermani Mehdi Mehdizadeh |
| author_sort | Sara Soleimani Asl |
| collection | DOAJ |
| description | Introduction: 3-4, methylenedioxymethamphetamine (MDMA) causes apoptosis in nervous system and several studies suggest that oxidative stress contributes to MDMA-induced neurotoxicity. The aim of this study is to examine the effects of N-acetyl-L-Cystein (NAC) as an antioxidant on MDMA-induced apoptosis. Methods: 21 Sprague dawley male rats (200-250mg) were treated with MDMA (2×0,5mg/kg) or MDMA plus NAC (100mg/kg IP for 7 day). After last administration of MDMA, rats were killed, cerebellum was removed and Bax and Bcl-2 expression was assessed by western blotting method. Results: The results of this study showed that MDMA causes up-regulation of Bax and down-regulation of Bcl-2 and NAC administration attenuated MDMA-induced apoptosis. Discussion: The present study suggests that NAC treatment may improve MDMA-induced neurotoxicity. |
| first_indexed | 2024-03-07T17:25:01Z |
| format | Article |
| id | doaj.art-2f4cf2c4e0aa4427858bdd24b9478f3f |
| institution | Directory Open Access Journal |
| issn | 2008-126X 2228-7442 |
| language | English |
| last_indexed | 2024-03-07T17:25:01Z |
| publishDate | 2011-10-01 |
| publisher | Iran University of Medical Sciences |
| record_format | Article |
| series | Basic and Clinical Neuroscience |
| spelling | doaj.art-2f4cf2c4e0aa4427858bdd24b9478f3f2024-03-02T19:16:37ZengIran University of Medical SciencesBasic and Clinical Neuroscience2008-126X2228-74422011-10-01314447Protective Effects of N-Acetyl-L-cystein on 3,4-Methylene Dioxymethamphetamie-Induced Neurotoxicity in Cerebellum of Male RatsSara Soleimani Asl0Peiman Falahati1Nima shekar riz2Nima Molavi3Farzaneh Esmaeili4Zahra Azimi5Freidoon Sajadi6Parisa Hayat7Alireza Samzadeh-Kermani8Mehdi Mehdizadeh9 Introduction: 3-4, methylenedioxymethamphetamine (MDMA) causes apoptosis in nervous system and several studies suggest that oxidative stress contributes to MDMA-induced neurotoxicity. The aim of this study is to examine the effects of N-acetyl-L-Cystein (NAC) as an antioxidant on MDMA-induced apoptosis. Methods: 21 Sprague dawley male rats (200-250mg) were treated with MDMA (2×0,5mg/kg) or MDMA plus NAC (100mg/kg IP for 7 day). After last administration of MDMA, rats were killed, cerebellum was removed and Bax and Bcl-2 expression was assessed by western blotting method. Results: The results of this study showed that MDMA causes up-regulation of Bax and down-regulation of Bcl-2 and NAC administration attenuated MDMA-induced apoptosis. Discussion: The present study suggests that NAC treatment may improve MDMA-induced neurotoxicity.http://bcn.iums.ac.ir/browse.php?a_code=A-10-1-90&slc_lang=en&sid=1ApoptosisN-Methyl-34-MethylenedioxyamphetamineAcetylcysteine |
| spellingShingle | Sara Soleimani Asl Peiman Falahati Nima shekar riz Nima Molavi Farzaneh Esmaeili Zahra Azimi Freidoon Sajadi Parisa Hayat Alireza Samzadeh-Kermani Mehdi Mehdizadeh Protective Effects of N-Acetyl-L-cystein on 3,4-Methylene Dioxymethamphetamie-Induced Neurotoxicity in Cerebellum of Male Rats Basic and Clinical Neuroscience Apoptosis N-Methyl-3 4-Methylenedioxyamphetamine Acetylcysteine |
| title | Protective Effects of N-Acetyl-L-cystein on 3,4-Methylene Dioxymethamphetamie-Induced Neurotoxicity in Cerebellum of Male Rats |
| title_full | Protective Effects of N-Acetyl-L-cystein on 3,4-Methylene Dioxymethamphetamie-Induced Neurotoxicity in Cerebellum of Male Rats |
| title_fullStr | Protective Effects of N-Acetyl-L-cystein on 3,4-Methylene Dioxymethamphetamie-Induced Neurotoxicity in Cerebellum of Male Rats |
| title_full_unstemmed | Protective Effects of N-Acetyl-L-cystein on 3,4-Methylene Dioxymethamphetamie-Induced Neurotoxicity in Cerebellum of Male Rats |
| title_short | Protective Effects of N-Acetyl-L-cystein on 3,4-Methylene Dioxymethamphetamie-Induced Neurotoxicity in Cerebellum of Male Rats |
| title_sort | protective effects of n acetyl l cystein on 3 4 methylene dioxymethamphetamie induced neurotoxicity in cerebellum of male rats |
| topic | Apoptosis N-Methyl-3 4-Methylenedioxyamphetamine Acetylcysteine |
| url | http://bcn.iums.ac.ir/browse.php?a_code=A-10-1-90&slc_lang=en&sid=1 |
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