Recent Updates on the Significance of KRAS Mutations in Colorectal Cancer Biology
The most commonly mutated isoform of RAS among all cancer subtypes is KRAS. In this review, we focus on the special role of KRAS mutations in colorectal cancer (CRC), aiming to collect recent data on KRAS-driven enhanced cell signalling, in vitro and in vivo research models, and CRC development-rela...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-03-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/10/3/667 |
| _version_ | 1797541029104058368 |
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| author | Loretta László Anita Kurilla Tamás Takács Gyöngyi Kudlik Kitti Koprivanacz László Buday Virag Vas |
| author_facet | Loretta László Anita Kurilla Tamás Takács Gyöngyi Kudlik Kitti Koprivanacz László Buday Virag Vas |
| author_sort | Loretta László |
| collection | DOAJ |
| description | The most commonly mutated isoform of RAS among all cancer subtypes is KRAS. In this review, we focus on the special role of KRAS mutations in colorectal cancer (CRC), aiming to collect recent data on KRAS-driven enhanced cell signalling, in vitro and in vivo research models, and CRC development-related processes such as metastasis and cancer stem cell formation. We attempt to cover the diverse nature of the effects of KRAS mutations on age-related CRC development. As the incidence of CRC is rising in young adults, we have reviewed the driving forces of ageing-dependent CRC. |
| first_indexed | 2024-03-10T13:09:28Z |
| format | Article |
| id | doaj.art-2f4d58052aef446f8f210e198c0eadac |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T13:09:28Z |
| publishDate | 2021-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-2f4d58052aef446f8f210e198c0eadac2023-11-21T10:51:51ZengMDPI AGCells2073-44092021-03-0110366710.3390/cells10030667Recent Updates on the Significance of KRAS Mutations in Colorectal Cancer BiologyLoretta László0Anita Kurilla1Tamás Takács2Gyöngyi Kudlik3Kitti Koprivanacz4László Buday5Virag Vas6Research Centre for Natural Sciences, Institute of Enzymology, 1051 Budapest, HungaryResearch Centre for Natural Sciences, Institute of Enzymology, 1051 Budapest, HungaryResearch Centre for Natural Sciences, Institute of Enzymology, 1051 Budapest, HungaryResearch Centre for Natural Sciences, Institute of Enzymology, 1051 Budapest, HungaryResearch Centre for Natural Sciences, Institute of Enzymology, 1051 Budapest, HungaryResearch Centre for Natural Sciences, Institute of Enzymology, 1051 Budapest, HungaryResearch Centre for Natural Sciences, Institute of Enzymology, 1051 Budapest, HungaryThe most commonly mutated isoform of RAS among all cancer subtypes is KRAS. In this review, we focus on the special role of KRAS mutations in colorectal cancer (CRC), aiming to collect recent data on KRAS-driven enhanced cell signalling, in vitro and in vivo research models, and CRC development-related processes such as metastasis and cancer stem cell formation. We attempt to cover the diverse nature of the effects of KRAS mutations on age-related CRC development. As the incidence of CRC is rising in young adults, we have reviewed the driving forces of ageing-dependent CRC.https://www.mdpi.com/2073-4409/10/3/667KRAScolorectal cancerRAS signallingcancer stem cellsRAS-driven metastasisCRC with age |
| spellingShingle | Loretta László Anita Kurilla Tamás Takács Gyöngyi Kudlik Kitti Koprivanacz László Buday Virag Vas Recent Updates on the Significance of KRAS Mutations in Colorectal Cancer Biology Cells KRAS colorectal cancer RAS signalling cancer stem cells RAS-driven metastasis CRC with age |
| title | Recent Updates on the Significance of KRAS Mutations in Colorectal Cancer Biology |
| title_full | Recent Updates on the Significance of KRAS Mutations in Colorectal Cancer Biology |
| title_fullStr | Recent Updates on the Significance of KRAS Mutations in Colorectal Cancer Biology |
| title_full_unstemmed | Recent Updates on the Significance of KRAS Mutations in Colorectal Cancer Biology |
| title_short | Recent Updates on the Significance of KRAS Mutations in Colorectal Cancer Biology |
| title_sort | recent updates on the significance of kras mutations in colorectal cancer biology |
| topic | KRAS colorectal cancer RAS signalling cancer stem cells RAS-driven metastasis CRC with age |
| url | https://www.mdpi.com/2073-4409/10/3/667 |
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