Recent Updates on the Significance of KRAS Mutations in Colorectal Cancer Biology

Recent Updates on the Significance of KRAS Mutations in Colorectal Cancer Biology

The most commonly mutated isoform of RAS among all cancer subtypes is KRAS. In this review, we focus on the special role of KRAS mutations in colorectal cancer (CRC), aiming to collect recent data on KRAS-driven enhanced cell signalling, in vitro and in vivo research models, and CRC development-rela...

Бүрэн тодорхойлолт

Номзүйн дэлгэрэнгүй
Үндсэн зохиолчид:	Loretta László, Anita Kurilla, Tamás Takács, Gyöngyi Kudlik, Kitti Koprivanacz, László Buday, Virag Vas
Формат:	Өгүүллэг
Хэл сонгох:	English
Хэвлэсэн:	MDPI AG 2021-03-01
Цуврал:	Cells
Нөхцлүүд:	KRAS colorectal cancer RAS signalling cancer stem cells RAS-driven metastasis CRC with age
Онлайн хандалт:	https://www.mdpi.com/2073-4409/10/3/667

Ижил төстэй зүйлс

Prevalence of RAS and BRAF mutations in metastatic colorectal cancer patients by tumor sidedness: A systematic review and meta‐analysis
-н: Lauren C. Bylsma, зэрэг
Хэвлэсэн: (2020-02-01)

Differential landscape of immune evasion in oncogenic RAS-driven primary and metastatic colorectal cancers
-н: Emil Lou, зэрэг
Хэвлэсэн: (2024-03-01)

Novel Roles of SH2 and SH3 Domains in Lipid Binding
-н: Szabolcs Sipeki, зэрэг
Хэвлэсэн: (2021-05-01)

Association of various RAS codon mutations and prognostic outcomes of patients with colorectal liver metastases after hepatectomy
-н: Xiao‐Gang Wu, зэрэг
Хэвлэсэн: (2024-10-01)

Natural Products Attenuating Biosynthesis, Processing, and Activity of Ras Oncoproteins: State of the Art and Future Perspectives
-н: Renata Tisi, зэрэг
Хэвлэсэн: (2020-11-01)

Targeting RAS – will GPR31 deliver us a new path forward?
-н: Nicole Fehrenbacher, зэрэг
Хэвлэсэн: (2017-11-01)

Targeting KRAS: from metabolic regulation to cancer treatment
-н: Yanyan Shi, зэрэг
Хэвлэсэн: (2025-01-01)

RAS mutation associated with short surgically controllable period in colorectal liver metastases: a retrospective study
-н: Sono Ito, зэрэг
Хэвлэсэн: (2024-09-01)

Guanine-Rich RNA Sequence Binding Factor 1 Deficiency Promotes Colorectal Cancer Progression by Regulating PI3K/AKT Signaling Pathway
-н: Huang J, зэрэг
Хэвлэсэн: (2024-06-01)

A Prospective, Multicenter, Observational Registry (ReCoRD) on Demography, Molecular Profile, Clinical Features, and Treatment Outcomes in Individuals undergoing Treatment for Metastatic Colorectal Cancer
-н: Sunil Kumar Yadav Y, зэрэг
Хэвлэсэн: (2023-10-01)

Probable autoimmune lymphoproliferative syndrome with monogenic lupus due to KRAS mutation - A rare encounter
-н: Amiya Nayak, зэрэг
Хэвлэсэн: (2024-02-01)

Monitoring ctDNA RAS Mutational Status in Metastatic Colorectal Cancer: A Trial Protocol of RAS-trace and RAS-trace-2 Studies
-н: Kozo Kataoka, зэрэг
Хэвлэсэн: (2024-04-01)

Predicting prognosis in colorectal cancer patients with curative resection using albumin, lymphocyte count and RAS mutations
-н: Toshiya Miyata, зэрэг
Хэвлэсэн: (2024-06-01)

A Bioinformatic Analysis Predicts That Cannabidiol Could Function as a Potential Inhibitor of the MAPK Pathway in Colorectal Cancer
-н: Julianne du Plessis, зэрэг
Хэвлэсэн: (2024-08-01)

Correlation between KRAS, NRAS and BRAF mutations and tumor localizations in patients with primary and metastatic colorectal cancer
-н: Aleksandra Bożyk, зэрэг
Хэвлэсэн: (2021-03-01)

Quadruplicate Synchronous Adenocarcinoma of the Colon with Distant Metastases—Long-Term Molecular Follow-Up by KRAS and TP53 Mutational Profiling
-н: Emese Sarolta Bádon, зэрэг
Хэвлэсэн: (2020-06-01)

Atypical Exon 2/3 Mutants G48C, Q43K, and E37K Present Oncogenic Phenotypes Distinct from Characterized NRAS Variants
-н: Mark Anthony G. Fran, зэрэг
Хэвлэсэн: (2024-10-01)

Molecular-genetic mechanisms of the signal cascade RAS-RAF-MEK-ERK associated with the development of the tumor process and the purpose of targeted drugs for colorectal cancer
-н: A. N. Toropovsky, зэрэг
Хэвлэсэн: (2021-08-01)

Impact of Age of Onset on Survival after Hepatectomy for Patients with Colorectal Cancer Liver Metastasis: A Real-World Single-Center Experience
-н: Hong-Wei Wang, зэрэг
Хэвлэсэн: (2022-11-01)

The role of KRAS and NRAS mutation detection in determining the therapy strategy for colorectal cancer
-н: A. N. Toropovskiy, зэрэг
Хэвлэсэн: (2022-11-01)

The Ins and Outs of RAS Effector Complexes
-н: Christina Kiel, зэрэг
Хэвлэсэн: (2021-02-01)

Preclinical Identification of Sulfasalazine’s Therapeutic Potential for Suppressing Colorectal Cancer Stemness and Metastasis through Targeting KRAS/MMP7/CD44 Signaling
-н: Wai-Hung Leung, зэрэг
Хэвлэсэн: (2022-02-01)

Erlotinib Treatment in Colorectal Cancer Suppresses Autophagy Based on <i>KRAS</i> Mutation
-н: Alexander Siegman, зэрэг
Хэвлэсэн: (2024-07-01)

KRAS genotypes predict metachronous colorectal cancer distant metastases after radical resections
-н: LIN Songbin, FENG Qingyang, XU Jianmin
Хэвлэсэн: (2021-01-01)

Targeting KRAS in Solid Tumors: Current Challenges and Future Opportunities of Novel KRAS Inhibitors
-н: Alice Indini, зэрэг
Хэвлэсэн: (2021-05-01)

Mutational Analyses of K-ras Exon 2 in Thailand Colorectal Cancer Tissue Samples
-н: Tanawan Kummalue, зэрэг
Хэвлэсэн: (2020-03-01)

Recent Developments in Targeting RAS Downstream Effectors for RAS-Driven Cancer Therapy
-н: Ozge Tatli, зэрэг
Хэвлэсэн: (2021-12-01)

Kras in metastatic colorectal cancer
-н: A Wicki, зэрэг
Хэвлэсэн: (2010-11-01)

Predictive value analysis of the interaction network of Tks4 scaffold protein in colon cancer
-н: Álmos Tilajka, зэрэг
Хэвлэсэн: (2024-08-01)

Binimetinib in combination with nivolumab or nivolumab and ipilimumab in patients with previously treated microsatellite-stable metastatic colorectal cancer with RAS mutations in an open-label phase 1b/2 study
-н: Elena Elez, зэрэг
Хэвлэсэн: (2024-04-01)

Molecular Pattern and Clinical Implications of KRAS/NRAS and BRAF Mutations in Colorectal Cancer
-н: İvo Gökmen, зэрэг
Хэвлэсэн: (2023-09-01)

Can factors that influence nodal dissemination in patients with colorectal cancer be identified? Own experience
-н: Konrad P. Zaręba, зэрэг
Хэвлэсэн: (2020-09-01)

KRAS as a predictor of poor prognosis and benefit from postoperative FOLFOX chemotherapy in patients with stage II and III colorectal cancer
-н: Yanhong Deng, зэрэг
Хэвлэсэн: (2015-08-01)

Determinación del gen Ras como factor pronóstico y predictivo en cáncer colorrectal metastásico en el Instituto de Oncología Dr. Heriberto Pieter, enero 2019 - diciembre 2021
-н: Sui Lanni María Ceballos Sang, зэрэг
Хэвлэсэн: (2024-06-01)

Case report of metastatic colorectal cancer associated with <i>KRAS</i> A146V and A59G mutations
-н: O. I. Kit, зэрэг
Хэвлэсэн: (2023-07-01)

Correlation Between DCAMKL-1 Protein Expression and K-ras Gene Mutation in Colorectal Cancer
-н: Wu X, зэрэг
Хэвлэсэн: (2024-01-01)

The metastasis-promoting P1597L mutation in PlexinB1 enhances Ras activity
-н: Ritu Garg, зэрэг
Хэвлэсэн: (2024-08-01)

Ras and Wnt Interaction Contribute in Prostate Cancer Bone Metastasis
-н: Shian-Ren Lin, зэрэг
Хэвлэсэн: (2020-05-01)

Modulation of Fibroblast Phenotype by Colorectal Cancer Cell-Secreted Factors Is Mostly Independent of Oncogenic KRAS
-н: Patrícia Dias Carvalho, зэрэг
Хэвлэсэн: (2022-08-01)

KRAS Mutation Status in Relation to Clinicopathological Characteristics of Romanian Colorectal Cancer Patients
-н: Elena-Roxana Avădănei, зэрэг
Хэвлэсэн: (2025-02-01)