Novel loss‐of‐function mutation in MCM8 causes premature ovarian insufficiency

Novel loss‐of‐function mutation in MCM8 causes premature ovarian insufficiency

Abstract Background Premature ovarian insufficiency (POI) is one major cause of female infertility, minichromosome maintenance complex component 8 (MCM8) has been reported to be responsible for POI. Methods Whole‐exome sequencing was performed to identify the genetic variants of women with POI. Sang...

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Bibliographic Details
Main Authors: Ya‐Xin Zhang, Wen‐Bin He, Wen‐Juan Xiao, Lan‐Lan Meng, Chen Tan, Juan Du, Guang‐Xiu Lu, Ge Lin, Yue‐Qiu Tan
Format: Article
Language:English
Published: Wiley 2020-04-01
Series:Molecular Genetics & Genomic Medicine
Subjects:
loss‐of‐function
MCM8 gene
premature ovarian insufficiency
whole‐exome sequencing
Online Access:https://doi.org/10.1002/mgg3.1165

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