Liver expression quantitative trait loci: a foundation for pharmacogenomic research
Expression quantitative trait loci (eQTL) analysis can provide insights into the genetic regulation of gene expression at a genomic level and this information is proving extremely useful in many different areas of research. As a consequence of the role of the liver in drug metabolism and disposition...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2012-08-01
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| Series: | Frontiers in Genetics |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fgene.2012.00153/full |
| _version_ | 1819029284841324544 |
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| author | Dylan eGlubb Neepa eDholakia Federico eInnocenti Federico eInnocenti |
| author_facet | Dylan eGlubb Neepa eDholakia Federico eInnocenti Federico eInnocenti |
| author_sort | Dylan eGlubb |
| collection | DOAJ |
| description | Expression quantitative trait loci (eQTL) analysis can provide insights into the genetic regulation of gene expression at a genomic level and this information is proving extremely useful in many different areas of research. As a consequence of the role of the liver in drug metabolism and disposition, the study of eQTLs in primary human liver tissue could provide a foundation for pharmacogenomics. Thus far, four genome-wide eQTL studies have been performed using human livers. Many liver eQTLs have been found to be reproducible and a proportion of these may be specific to the liver. Already these data have been used to interpret and inform clinic genome-wide association studies, providing potential mechanistic evidence for clinical associations and identifying genes which may impact on clinical phenotypes. However, the utility of liver eQTL data has not yet been fully explored or realized in pharmacogenomics. As further liver eQTL research is undertaken, the genetic regulation of gene expression will become much better characterized and this knowledge will create a rational basis for the prospective pharmacogenomic study of many drugs. |
| first_indexed | 2024-12-21T06:11:49Z |
| format | Article |
| id | doaj.art-2f4fef3f7bc14799a86e4cc721b535bf |
| institution | Directory Open Access Journal |
| issn | 1664-8021 |
| language | English |
| last_indexed | 2024-12-21T06:11:49Z |
| publishDate | 2012-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Genetics |
| spelling | doaj.art-2f4fef3f7bc14799a86e4cc721b535bf2022-12-21T19:13:31ZengFrontiers Media S.A.Frontiers in Genetics1664-80212012-08-01310.3389/fgene.2012.0015330837Liver expression quantitative trait loci: a foundation for pharmacogenomic researchDylan eGlubb0Neepa eDholakia1Federico eInnocenti2Federico eInnocenti3The University of North Carolina at Chapel HillThe University of North Carolina at Chapel HillThe University of North Carolina at Chapel HillUniversity of North Carolina at Chapel HillExpression quantitative trait loci (eQTL) analysis can provide insights into the genetic regulation of gene expression at a genomic level and this information is proving extremely useful in many different areas of research. As a consequence of the role of the liver in drug metabolism and disposition, the study of eQTLs in primary human liver tissue could provide a foundation for pharmacogenomics. Thus far, four genome-wide eQTL studies have been performed using human livers. Many liver eQTLs have been found to be reproducible and a proportion of these may be specific to the liver. Already these data have been used to interpret and inform clinic genome-wide association studies, providing potential mechanistic evidence for clinical associations and identifying genes which may impact on clinical phenotypes. However, the utility of liver eQTL data has not yet been fully explored or realized in pharmacogenomics. As further liver eQTL research is undertaken, the genetic regulation of gene expression will become much better characterized and this knowledge will create a rational basis for the prospective pharmacogenomic study of many drugs.http://journal.frontiersin.org/Journal/10.3389/fgene.2012.00153/fullLiverGWASADME genesclinical pharmacogenomicsexpression quantitative trait loci |
| spellingShingle | Dylan eGlubb Neepa eDholakia Federico eInnocenti Federico eInnocenti Liver expression quantitative trait loci: a foundation for pharmacogenomic research Frontiers in Genetics Liver GWAS ADME genes clinical pharmacogenomics expression quantitative trait loci |
| title | Liver expression quantitative trait loci: a foundation for pharmacogenomic research |
| title_full | Liver expression quantitative trait loci: a foundation for pharmacogenomic research |
| title_fullStr | Liver expression quantitative trait loci: a foundation for pharmacogenomic research |
| title_full_unstemmed | Liver expression quantitative trait loci: a foundation for pharmacogenomic research |
| title_short | Liver expression quantitative trait loci: a foundation for pharmacogenomic research |
| title_sort | liver expression quantitative trait loci a foundation for pharmacogenomic research |
| topic | Liver GWAS ADME genes clinical pharmacogenomics expression quantitative trait loci |
| url | http://journal.frontiersin.org/Journal/10.3389/fgene.2012.00153/full |
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