Chemical proteomics approach reveals the direct targets and the heme-dependent activation mechanism of artemisinin in Plasmodium falciparum using an activity-based artemisinin probe

Chemical proteomics approach reveals the direct targets and the heme-dependent activation mechanism of artemisinin in Plasmodium falciparum using an activity-based artemisinin probe

Artemisinin and its analogues are currently the most effective anti-malarial drugs. The activation of artemisinin requires the cleavage of the endoperoxide bridge in the presence of iron sources. Once activated, artemisinins attack macromolecules through alkylation and propagate a series of damages,...

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Hlavní autoři: Jigang Wang, Qingsong Lin
Médium: Článek
Jazyk:English
Vydáno: Shared Science Publishers OG 2016-04-01
Edice:Microbial Cell
Témata:
target
mechanism of action
activation
heme
artemisinin
activity-based probe
chemical proteomics
malaria
artemisinin resistance
On-line přístup:http://microbialcell.com/researcharticles/chemical-proteomics-approach-reveals-the-direct-targets-and-the-heme-dependent-activation-mechanism-of-artemisinin-in-plasmodium-falciparum-using-an-activity-based-artemisinin-probe/

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http://microbialcell.com/researcharticles/chemical-proteomics-approach-reveals-the-direct-targets-and-the-heme-dependent-activation-mechanism-of-artemisinin-in-plasmodium-falciparum-using-an-activity-based-artemisinin-probe/

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