A new model of self-resolving leptospirosis in mice infected with a strain of Leptospira interrogans serovar Autumnalis harboring LPS signaling only through TLR4

A new model of self-resolving leptospirosis in mice infected with a strain of Leptospira interrogans serovar Autumnalis harboring LPS signaling only through TLR4

Leptospirosis is an emerging worldwide zoonosis caused by pathogenic Leptospira spp. Our understanding of leptospirosis pathogenesis and host immune response remains limited, while mechanistic studies are hindered by a lack of proper animal models and immunological reagents. Here we established a mu...

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Bibliographic Details
Main Authors: Bili Xia, Le Sun, Xia Fan, Haihan Xiao, Yongzhang Zhu, Jinhong Qin, Chengsong Cai, Wei Zhao, Yung-Fu Chang, Yan Zhang, Xiaokui Guo, Ping He
Format: Article
Language:English
Published: Taylor & Francis Group 2017-01-01
Series:Emerging Microbes and Infections
Subjects:
leptospires
lipopolysaccharide
mouse model
TLR4
Online Access:https://www.tandfonline.com/doi/10.1038/emi.2017.16

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