Studying Kidney Diseases at the Single-Cell Level
Background: The kidney is a highly complex organ that performs diverse functions that are essential for health. Kidney disease occurs when the kidneys are damaged and fail to function properly. Single-cell analysis is a powerful technology that provides unprecedented insights into normal and abnorma...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Karger Publishers
2021-07-01
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| Series: | Kidney Diseases |
| Subjects: | |
| Online Access: | https://www.karger.com/Article/FullText/517130 |
| _version_ | 1819145769586786304 |
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| author | Mengmeng Jiang Haide Chen Guoji Guo |
| author_facet | Mengmeng Jiang Haide Chen Guoji Guo |
| author_sort | Mengmeng Jiang |
| collection | DOAJ |
| description | Background: The kidney is a highly complex organ that performs diverse functions that are essential for health. Kidney disease occurs when the kidneys are damaged and fail to function properly. Single-cell analysis is a powerful technology that provides unprecedented insights into normal and abnormal kidney cell types and will transform our understanding of the mechanism underlying common kidney diseases. Summary: Our understanding of kidney disease pathogenesis is limited by the incomplete molecular characterization of cell types responsible for kidney functions. Application of single-cell technologies for the study of the kidney has revealed cellular heterogeneity, gene expression signatures, and molecular dynamics during the onset and development of kidney diseases. Single-cell analyses of kidney organoids and allograft tissues offer new insights into kidney organogenesis, disease mechanisms, and therapeutic outcomes. Collectively, a better understanding of kidney cell heterogeneity and the molecular dynamics of kidney diseases will improve diagnostic accuracy and facilitate the identification of novel treatment strategies in nephrology. Key Message: In this review article, we summarize recent single-cell studies on kidney diseases and discuss the impact of single-cell technology on both basic and clinical nephrology research. |
| first_indexed | 2024-12-22T13:03:18Z |
| format | Article |
| id | doaj.art-2f54b1bf8ec64fec937b4c3ad59eed0c |
| institution | Directory Open Access Journal |
| issn | 2296-9381 2296-9357 |
| language | English |
| last_indexed | 2024-12-22T13:03:18Z |
| publishDate | 2021-07-01 |
| publisher | Karger Publishers |
| record_format | Article |
| series | Kidney Diseases |
| spelling | doaj.art-2f54b1bf8ec64fec937b4c3ad59eed0c2022-12-21T18:24:56ZengKarger PublishersKidney Diseases2296-93812296-93572021-07-017533534210.1159/000517130517130Studying Kidney Diseases at the Single-Cell LevelMengmeng Jiang0Haide Chen1Guoji Guo2Liangzhu Laboratory, Zhejiang University Medical Center, Hangzhou, ChinaCenter for Stem Cell and Regenerative Medicine, Zhejiang University School of Medicine, Hangzhou, ChinaLiangzhu Laboratory, Zhejiang University Medical Center, Hangzhou, ChinaBackground: The kidney is a highly complex organ that performs diverse functions that are essential for health. Kidney disease occurs when the kidneys are damaged and fail to function properly. Single-cell analysis is a powerful technology that provides unprecedented insights into normal and abnormal kidney cell types and will transform our understanding of the mechanism underlying common kidney diseases. Summary: Our understanding of kidney disease pathogenesis is limited by the incomplete molecular characterization of cell types responsible for kidney functions. Application of single-cell technologies for the study of the kidney has revealed cellular heterogeneity, gene expression signatures, and molecular dynamics during the onset and development of kidney diseases. Single-cell analyses of kidney organoids and allograft tissues offer new insights into kidney organogenesis, disease mechanisms, and therapeutic outcomes. Collectively, a better understanding of kidney cell heterogeneity and the molecular dynamics of kidney diseases will improve diagnostic accuracy and facilitate the identification of novel treatment strategies in nephrology. Key Message: In this review article, we summarize recent single-cell studies on kidney diseases and discuss the impact of single-cell technology on both basic and clinical nephrology research.https://www.karger.com/Article/FullText/517130single-cell technologykidney diseaseimmune cellkidney organoidallograft |
| spellingShingle | Mengmeng Jiang Haide Chen Guoji Guo Studying Kidney Diseases at the Single-Cell Level Kidney Diseases single-cell technology kidney disease immune cell kidney organoid allograft |
| title | Studying Kidney Diseases at the Single-Cell Level |
| title_full | Studying Kidney Diseases at the Single-Cell Level |
| title_fullStr | Studying Kidney Diseases at the Single-Cell Level |
| title_full_unstemmed | Studying Kidney Diseases at the Single-Cell Level |
| title_short | Studying Kidney Diseases at the Single-Cell Level |
| title_sort | studying kidney diseases at the single cell level |
| topic | single-cell technology kidney disease immune cell kidney organoid allograft |
| url | https://www.karger.com/Article/FullText/517130 |
| work_keys_str_mv | AT mengmengjiang studyingkidneydiseasesatthesinglecelllevel AT haidechen studyingkidneydiseasesatthesinglecelllevel AT guojiguo studyingkidneydiseasesatthesinglecelllevel |