The Impact of Aspirin on Stem Cells and Growth Factors: Roles in Dentistry
The periodontal ligament (PDL) contains a unique population of mesenchymal stem cells (MSCs), also known as PDL stem cells (PDLSCs). The regenerative properties of PDLSCs offer much potential for stem cell-based therapy, particularly for periodontal or bone regeneration. Aspirin (ASA) is a widely us...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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International Medical Research and Development Corporation
2023-06-01
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| Series: | International Journal of Biomedicine |
| Subjects: | |
| Online Access: | http://www.ijbm.org/articles/i50/ijbm_13(2)_ra1.pdf |
| _version_ | 1797807363785228288 |
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| author | Fazliny Abd. Rahman Nur Fatinazwa Mohd Faizal Lee Peng Karen-N Sulinda Daud Ahmad Termizi Zamzuri |
| author_facet | Fazliny Abd. Rahman Nur Fatinazwa Mohd Faizal Lee Peng Karen-N Sulinda Daud Ahmad Termizi Zamzuri |
| author_sort | Fazliny Abd. Rahman |
| collection | DOAJ |
| description | The periodontal ligament (PDL) contains a unique population of mesenchymal stem cells (MSCs), also known as PDL stem cells (PDLSCs). The regenerative properties of PDLSCs offer much potential for stem cell-based therapy, particularly for periodontal or bone regeneration. Aspirin (ASA) is a widely used nonsteroidal anti-inflammatory drug (NSAID) that has been reported to modulate a variety of diseases, such as cardiovascular, diabetes, and cancer. This review article focuses on the impacts of ASA on various stem cells. First, we will explain what constitutes PDLSCs and their derivation from periodontal tissues. Then we will discuss the mechanisms of ASA and its effect on periodontal tissues. Next, we focus on aspirin’s effects on the differentiation of various types of stem cells. Finally, we investigate the effects of ASA on growth factors that could enhance the osteoblastic potential of derived stem cells. |
| first_indexed | 2024-03-13T06:21:28Z |
| format | Article |
| id | doaj.art-2f585f102e1a456ebb8962864d12b034 |
| institution | Directory Open Access Journal |
| issn | 2158-0510 2158-0529 |
| language | English |
| last_indexed | 2024-03-13T06:21:28Z |
| publishDate | 2023-06-01 |
| publisher | International Medical Research and Development Corporation |
| record_format | Article |
| series | International Journal of Biomedicine |
| spelling | doaj.art-2f585f102e1a456ebb8962864d12b0342023-06-09T16:55:04ZengInternational Medical Research and Development CorporationInternational Journal of Biomedicine2158-05102158-05292023-06-0113218819310.21103/Article13(2)_RA1The Impact of Aspirin on Stem Cells and Growth Factors: Roles in Dentistry Fazliny Abd. Rahman0Nur Fatinazwa Mohd Faizal1Lee Peng Karen-N2Sulinda Daud3Ahmad Termizi Zamzuri4Faculty of Dentistry, SEGi University, Petaling Jaya, Selangor, MalaysiaOral Cancer Research & Coordinating Centre, Faculty of Dentistry, University of Malaya, 50603 Kuala Lumpur, Malaysia Oral Cancer Research & Coordinating Centre, Faculty of Dentistry, University of Malaya, 50603 Kuala Lumpur, Malaysia Faculty of Dentistry, SEGi University, Petaling Jaya, Selangor, MalaysiaFaculty of Dentistry, SEGi University, Petaling Jaya, Selangor, MalaysiaThe periodontal ligament (PDL) contains a unique population of mesenchymal stem cells (MSCs), also known as PDL stem cells (PDLSCs). The regenerative properties of PDLSCs offer much potential for stem cell-based therapy, particularly for periodontal or bone regeneration. Aspirin (ASA) is a widely used nonsteroidal anti-inflammatory drug (NSAID) that has been reported to modulate a variety of diseases, such as cardiovascular, diabetes, and cancer. This review article focuses on the impacts of ASA on various stem cells. First, we will explain what constitutes PDLSCs and their derivation from periodontal tissues. Then we will discuss the mechanisms of ASA and its effect on periodontal tissues. Next, we focus on aspirin’s effects on the differentiation of various types of stem cells. Finally, we investigate the effects of ASA on growth factors that could enhance the osteoblastic potential of derived stem cells.http://www.ijbm.org/articles/i50/ijbm_13(2)_ra1.pdfacetylsalicylic acidperiodontal ligamentstem cells |
| spellingShingle | Fazliny Abd. Rahman Nur Fatinazwa Mohd Faizal Lee Peng Karen-N Sulinda Daud Ahmad Termizi Zamzuri The Impact of Aspirin on Stem Cells and Growth Factors: Roles in Dentistry International Journal of Biomedicine acetylsalicylic acid periodontal ligament stem cells |
| title | The Impact of Aspirin on Stem Cells and Growth Factors: Roles in Dentistry |
| title_full | The Impact of Aspirin on Stem Cells and Growth Factors: Roles in Dentistry |
| title_fullStr | The Impact of Aspirin on Stem Cells and Growth Factors: Roles in Dentistry |
| title_full_unstemmed | The Impact of Aspirin on Stem Cells and Growth Factors: Roles in Dentistry |
| title_short | The Impact of Aspirin on Stem Cells and Growth Factors: Roles in Dentistry |
| title_sort | impact of aspirin on stem cells and growth factors roles in dentistry |
| topic | acetylsalicylic acid periodontal ligament stem cells |
| url | http://www.ijbm.org/articles/i50/ijbm_13(2)_ra1.pdf |
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