Endometrial Preparation for Women Undergoing Embryo Transfer Frozen-Thawed Embryo Transfer With and Without Pretreatment With Gonadotropin Releasing Hormone Agonists
Objective: To evaluate the efficacy of endometrial preparation by exogenous steroids, with and without pretreatment by the use of GnRH agonist. Materials and methods: This randomized interventional study was conducted on 100 women who underwent a FTET that were randomly assigned to receive GnRH agon...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Tehran University of Medical Sciences
2019-02-01
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| Series: | Journal of Family and Reproductive Health |
| Subjects: | |
| Online Access: | https://jfrh.tums.ac.ir/index.php/jfrh/article/view/945 |
| _version_ | 1818900826725285888 |
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| author | Shohreh Movahedi Ashraf Aleyasin Marzieh Agahoseini Leili Safdarian Sahar Abroshan Sepideh Khodaverdi Parvin Fallahi |
| author_facet | Shohreh Movahedi Ashraf Aleyasin Marzieh Agahoseini Leili Safdarian Sahar Abroshan Sepideh Khodaverdi Parvin Fallahi |
| author_sort | Shohreh Movahedi |
| collection | DOAJ |
| description | Objective: To evaluate the efficacy of endometrial preparation by exogenous steroids, with and without pretreatment by the use of GnRH agonist.
Materials and methods: This randomized interventional study was conducted on 100 women who underwent a FTET that were randomly assigned to receive GnRH agonist (buserelin) in the luteal phase or no receive this medication. In both groups endometrial preparation was achieved by the use of estradiol valerate pill started from the second day of the menstruation and used every day, with an initial dose of 2mg/d and every 3 days increased to 4 mg/d and 6 mg/d, respectively. Endometrial thickness was evaluated by vaginal ultrasound. Forty eight hours after beginning of progesterone administration 2 to 3 embryos surviving in freezing procedure were transferred.
Results: the two groups were similar in mean age, body mass index, duration of infertility, type of infertility, number of embryos transferred and endometrial thickness on the day of beginning progesterone therapy. Comparing outcome of FTET between the two groups scheduled for receiving GnRH agonist showed no significant difference in the rate of implantation (6.7% versus 10.0%), the rate of chemical pregnancy (21.7% versus 22.5%), clinical pregnancy rate (15.0% versus 17.5%), and also ongoing pregnancy (13.3% versus 12.5%).
Conclusion: Endometrial preparation for FTET using GnRH agonists appears to be as effective as FTET without administrating these agonists. |
| first_indexed | 2024-12-19T20:10:02Z |
| format | Article |
| id | doaj.art-2f58716cb0f64a598900d7815d42bd1c |
| institution | Directory Open Access Journal |
| issn | 1735-8949 1735-9392 |
| language | English |
| last_indexed | 2024-12-19T20:10:02Z |
| publishDate | 2019-02-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | Journal of Family and Reproductive Health |
| spelling | doaj.art-2f58716cb0f64a598900d7815d42bd1c2022-12-21T20:07:21ZengTehran University of Medical SciencesJournal of Family and Reproductive Health1735-89491735-93922019-02-01124945Endometrial Preparation for Women Undergoing Embryo Transfer Frozen-Thawed Embryo Transfer With and Without Pretreatment With Gonadotropin Releasing Hormone AgonistsShohreh Movahedi0Ashraf Aleyasin1Marzieh Agahoseini2Leili Safdarian3Sahar Abroshan4Sepideh Khodaverdi5Parvin Fallahi6Department of Infertility of Shariati Hospital, Tehran University of Medical Sciences, Tehran, IranDepartment of Infertility of Shariati Hospital, Tehran University of Medical Sciences, Tehran, IranDepartment of Infertility of Shariati Hospital, Tehran University of Medical Sciences, Tehran, IranDepartment of Infertility of Shariati Hospital, Tehran University of Medical Sciences, Tehran, IranDepartment of Obstetrics and Gynecology, Tehran University of Medical Sciences, Tehran, IranDepartment of Obstetrics and Gynecology, Fellowship in Minimally Invasive Gynecology Surgery (FMIGS),Endometriosis Research Center of Rasoul Akram Hospital, Iran University of Medical Sciences , Tehran, IranDepartment of Infertility, Shariati Hospital, Tehran University of Medical Sciences, Tehran, IranObjective: To evaluate the efficacy of endometrial preparation by exogenous steroids, with and without pretreatment by the use of GnRH agonist. Materials and methods: This randomized interventional study was conducted on 100 women who underwent a FTET that were randomly assigned to receive GnRH agonist (buserelin) in the luteal phase or no receive this medication. In both groups endometrial preparation was achieved by the use of estradiol valerate pill started from the second day of the menstruation and used every day, with an initial dose of 2mg/d and every 3 days increased to 4 mg/d and 6 mg/d, respectively. Endometrial thickness was evaluated by vaginal ultrasound. Forty eight hours after beginning of progesterone administration 2 to 3 embryos surviving in freezing procedure were transferred. Results: the two groups were similar in mean age, body mass index, duration of infertility, type of infertility, number of embryos transferred and endometrial thickness on the day of beginning progesterone therapy. Comparing outcome of FTET between the two groups scheduled for receiving GnRH agonist showed no significant difference in the rate of implantation (6.7% versus 10.0%), the rate of chemical pregnancy (21.7% versus 22.5%), clinical pregnancy rate (15.0% versus 17.5%), and also ongoing pregnancy (13.3% versus 12.5%). Conclusion: Endometrial preparation for FTET using GnRH agonists appears to be as effective as FTET without administrating these agonists.https://jfrh.tums.ac.ir/index.php/jfrh/article/view/945Endometrial PreparationEmbryo TransferFrozen-ThawedGonadotropinHormone AgonistsWomen |
| spellingShingle | Shohreh Movahedi Ashraf Aleyasin Marzieh Agahoseini Leili Safdarian Sahar Abroshan Sepideh Khodaverdi Parvin Fallahi Endometrial Preparation for Women Undergoing Embryo Transfer Frozen-Thawed Embryo Transfer With and Without Pretreatment With Gonadotropin Releasing Hormone Agonists Journal of Family and Reproductive Health Endometrial Preparation Embryo Transfer Frozen-Thawed Gonadotropin Hormone Agonists Women |
| title | Endometrial Preparation for Women Undergoing Embryo Transfer Frozen-Thawed Embryo Transfer With and Without Pretreatment With Gonadotropin Releasing Hormone Agonists |
| title_full | Endometrial Preparation for Women Undergoing Embryo Transfer Frozen-Thawed Embryo Transfer With and Without Pretreatment With Gonadotropin Releasing Hormone Agonists |
| title_fullStr | Endometrial Preparation for Women Undergoing Embryo Transfer Frozen-Thawed Embryo Transfer With and Without Pretreatment With Gonadotropin Releasing Hormone Agonists |
| title_full_unstemmed | Endometrial Preparation for Women Undergoing Embryo Transfer Frozen-Thawed Embryo Transfer With and Without Pretreatment With Gonadotropin Releasing Hormone Agonists |
| title_short | Endometrial Preparation for Women Undergoing Embryo Transfer Frozen-Thawed Embryo Transfer With and Without Pretreatment With Gonadotropin Releasing Hormone Agonists |
| title_sort | endometrial preparation for women undergoing embryo transfer frozen thawed embryo transfer with and without pretreatment with gonadotropin releasing hormone agonists |
| topic | Endometrial Preparation Embryo Transfer Frozen-Thawed Gonadotropin Hormone Agonists Women |
| url | https://jfrh.tums.ac.ir/index.php/jfrh/article/view/945 |
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