Relative Change of Protidemia Level Predicts Intradialytic Hypotension
Background Hemodialysis patients are at risk of intradialytic hypotension (IDH), which is associated with mortality and cardiovascular and neurological events. The use of biomarkers of volemia such as relative change in protidemia and BNP (B‐natriuretic peptide) levels to predict IDH remains unknown...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2020-01-01
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| Series: | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| Subjects: | |
| Online Access: | https://www.ahajournals.org/doi/10.1161/JAHA.119.014264 |
| _version_ | 1811334119255179264 |
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| author | Maureen Assayag David Levy Pascal Seris Catherine Maheas Anne‐Lyse Langlois Kamal Moubakir Sophie Laplanche Christophe Ridel Maxime Touzot |
| author_facet | Maureen Assayag David Levy Pascal Seris Catherine Maheas Anne‐Lyse Langlois Kamal Moubakir Sophie Laplanche Christophe Ridel Maxime Touzot |
| author_sort | Maureen Assayag |
| collection | DOAJ |
| description | Background Hemodialysis patients are at risk of intradialytic hypotension (IDH), which is associated with mortality and cardiovascular and neurological events. The use of biomarkers of volemia such as relative change in protidemia and BNP (B‐natriuretic peptide) levels to predict IDH remains unknown. Methods and Results We conducted a prospective observational study, which enrolled 170 chronic hemodialysis patients in a single center from September 2015 to March 2016. BNP and the relative change of protidemia level (Δprotidemia=postdialysis protidemia−predialysis protidemia) were measured monthly over 6 months. A logistic mixed regression model was used to define the best biomarkers that predict the 30‐day risk of IDH. Receiver operating characteristic analysis area under the curve was used to define the cutoff values of Δprotidemia that predict IDH A logistic mixed model reveals that Δprotidemia predicts the 30‐day risk of IDH but not BNP or age; odds ratio=1.12, 95% CI 1.08‐1.17), odds ratio=0.81, 95% CI (0.64; 1.07) and odds ratio =0.015 95% CI (0.99; 1.03), respectively. Adding the ultrafiltration rate did not improve the model. A receiver operating characteristic curve analysis showed that Δprotidemia of 10 g/L allowed for discrimination of the patients with IDH (area under the curve= 0.67; 95% CI 0.62‐0.72, P<0.05). There was an increase in area under the curve to 0.71 (95% CI 0.63‐0.76) in a subgroup of hemodialysis with BNP <300 ng/L, for a cutoff value of 11 g/L, especially for the nondiabetic patients. Conclusions Relative change in protidemia level (Δprotidemia) outperforms BNP and ultrafiltration rate as a predictor for 30‐day risk of IDH. These results should be confirmed by a prospective study. |
| first_indexed | 2024-04-13T17:03:06Z |
| format | Article |
| id | doaj.art-2f58e5a9950643f181e503586d1ff39e |
| institution | Directory Open Access Journal |
| issn | 2047-9980 |
| language | English |
| last_indexed | 2024-04-13T17:03:06Z |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| spelling | doaj.art-2f58e5a9950643f181e503586d1ff39e2022-12-22T02:38:35ZengWileyJournal of the American Heart Association: Cardiovascular and Cerebrovascular Disease2047-99802020-01-019110.1161/JAHA.119.014264Relative Change of Protidemia Level Predicts Intradialytic HypotensionMaureen Assayag0David Levy1Pascal Seris2Catherine Maheas3Anne‐Lyse Langlois4Kamal Moubakir5Sophie Laplanche6Christophe Ridel7Maxime Touzot8Urgences Néphrologiques et Transplantation Rénale Hôpital Tenon Paris FranceService de Medecine Interne Centre Hospitalier de Soisson Soisson FranceDialyse et Aphérèse Thérapeutique AURA Paris Plaisance Paris FranceDialyse et Aphérèse Thérapeutique AURA Paris Plaisance Paris FranceDialyse et Aphérèse Thérapeutique AURA Paris Plaisance Paris FranceDialyse et Aphérèse Thérapeutique AURA Paris Plaisance Paris FranceLaboratoire de Biologie Médicale Groupe Hospitalier Saint‐Joseph Paris FranceDialyse et Aphérèse Thérapeutique AURA Paris Plaisance Paris FranceDialyse et Aphérèse Thérapeutique AURA Paris Plaisance Paris FranceBackground Hemodialysis patients are at risk of intradialytic hypotension (IDH), which is associated with mortality and cardiovascular and neurological events. The use of biomarkers of volemia such as relative change in protidemia and BNP (B‐natriuretic peptide) levels to predict IDH remains unknown. Methods and Results We conducted a prospective observational study, which enrolled 170 chronic hemodialysis patients in a single center from September 2015 to March 2016. BNP and the relative change of protidemia level (Δprotidemia=postdialysis protidemia−predialysis protidemia) were measured monthly over 6 months. A logistic mixed regression model was used to define the best biomarkers that predict the 30‐day risk of IDH. Receiver operating characteristic analysis area under the curve was used to define the cutoff values of Δprotidemia that predict IDH A logistic mixed model reveals that Δprotidemia predicts the 30‐day risk of IDH but not BNP or age; odds ratio=1.12, 95% CI 1.08‐1.17), odds ratio=0.81, 95% CI (0.64; 1.07) and odds ratio =0.015 95% CI (0.99; 1.03), respectively. Adding the ultrafiltration rate did not improve the model. A receiver operating characteristic curve analysis showed that Δprotidemia of 10 g/L allowed for discrimination of the patients with IDH (area under the curve= 0.67; 95% CI 0.62‐0.72, P<0.05). There was an increase in area under the curve to 0.71 (95% CI 0.63‐0.76) in a subgroup of hemodialysis with BNP <300 ng/L, for a cutoff value of 11 g/L, especially for the nondiabetic patients. Conclusions Relative change in protidemia level (Δprotidemia) outperforms BNP and ultrafiltration rate as a predictor for 30‐day risk of IDH. These results should be confirmed by a prospective study.https://www.ahajournals.org/doi/10.1161/JAHA.119.014264brain natriuretic peptidedialysishemoconcentrationhypotension |
| spellingShingle | Maureen Assayag David Levy Pascal Seris Catherine Maheas Anne‐Lyse Langlois Kamal Moubakir Sophie Laplanche Christophe Ridel Maxime Touzot Relative Change of Protidemia Level Predicts Intradialytic Hypotension Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease brain natriuretic peptide dialysis hemoconcentration hypotension |
| title | Relative Change of Protidemia Level Predicts Intradialytic Hypotension |
| title_full | Relative Change of Protidemia Level Predicts Intradialytic Hypotension |
| title_fullStr | Relative Change of Protidemia Level Predicts Intradialytic Hypotension |
| title_full_unstemmed | Relative Change of Protidemia Level Predicts Intradialytic Hypotension |
| title_short | Relative Change of Protidemia Level Predicts Intradialytic Hypotension |
| title_sort | relative change of protidemia level predicts intradialytic hypotension |
| topic | brain natriuretic peptide dialysis hemoconcentration hypotension |
| url | https://www.ahajournals.org/doi/10.1161/JAHA.119.014264 |
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