Cross‐species chemogenomic profiling reveals evolutionarily conserved drug mode of action

Cross‐species chemogenomic profiling reveals evolutionarily conserved drug mode of action

Abstract We present a cross‐species chemogenomic screening platform using libraries of haploid deletion mutants from two yeast species, Saccharomyces cerevisiae and Schizosaccharomyces pombe. We screened a set of compounds of known and unknown mode of action (MoA) and derived quantitative drug score...

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Bibliographic Details
Main Authors: Laura Kapitzky, Pedro Beltrao, Theresa J Berens, Nadine Gassner, Chunshui Zhou, Arthur Wüster, Julie Wu, M Madan Babu, Stephen J Elledge, David Toczyski, R Scott Lokey, Nevan J Krogan
Format: Article
Language:English
Published: Springer Nature 2010-12-01
Series:Molecular Systems Biology
Subjects:
chemogenomics
evolution
modularity
Online Access:https://doi.org/10.1038/msb.2010.107

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