Clinical characteristics, breed differences, and quality of life in North American dogs with acute steroid‐responsive meningitis‐arteritis
Abstract Background Steroid‐responsive meningitis‐arteritis (SRMA) is a common inflammatory neurologic disorder of dogs for which certain breeds are predisposed. Objectives To determine whether breed differences exist in clinical features, treatment response, and relapse in a population of North Ame...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2019-07-01
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| Series: | Journal of Veterinary Internal Medicine |
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| Online Access: | https://doi.org/10.1111/jvim.15543 |
| _version_ | 1811344105935994880 |
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| author | Jeanie Lau Julie A. Nettifee Peter J. Early Christopher L. Mariani Natasha J. Olby Karen R. Muñana |
| author_facet | Jeanie Lau Julie A. Nettifee Peter J. Early Christopher L. Mariani Natasha J. Olby Karen R. Muñana |
| author_sort | Jeanie Lau |
| collection | DOAJ |
| description | Abstract Background Steroid‐responsive meningitis‐arteritis (SRMA) is a common inflammatory neurologic disorder of dogs for which certain breeds are predisposed. Objectives To determine whether breed differences exist in clinical features, treatment response, and relapse in a population of North American dogs with SRMA, and to evaluate the effect of disease on dogs' quality of life (QoL). Animals Sixty‐one client‐owned dogs with SRMA: 29 dogs identified through an American Kennel Club‐Canine Health Foundation survey and 32 dogs from North Carolina (NC) State Veterinary Hospital. Methods Retrospective case series. Caregivers completed an online survey to assess QoL. Results Breeds represented most often included the Golden Retriever (n = 12), Bernese Mountain Dog (10), Wirehaired Pointing Griffon (9), Boxer (9), and Beagle (6). No breed differences were identified with respect to clinical severity, diagnostic findings, or outcome. Twenty‐nine dogs (48%) had ≥1 disease relapse. There was a significant effect of cerebrospinal fluid nucleated cell count on the frequency of disease relapse (P = .003), but no relationship was identified between treatment protocol and relapse. Dogs' QoL was associated with the severity of corticosteroid‐related adverse effects (P = .03), which were dose‐related (r = .24, P = .02) and more prevalent in Wirehaired Pointing Griffons than in other breeds (P = .04). Conclusion and Clinical Importance Golden Retrievers and Wirehaired Pointing Griffons should be considered among the breeds recognized to develop SRMA. Treatment with higher corticosteroid dosages is correlated with more severe adverse effects and worse QoL, but it may not improve clinical outcome. |
| first_indexed | 2024-04-13T19:41:53Z |
| format | Article |
| id | doaj.art-2f5a3e4a88594fae8f51e4f8adbad8c1 |
| institution | Directory Open Access Journal |
| issn | 0891-6640 1939-1676 |
| language | English |
| last_indexed | 2024-04-13T19:41:53Z |
| publishDate | 2019-07-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Veterinary Internal Medicine |
| spelling | doaj.art-2f5a3e4a88594fae8f51e4f8adbad8c12022-12-22T02:32:52ZengWileyJournal of Veterinary Internal Medicine0891-66401939-16762019-07-013341719172710.1111/jvim.15543Clinical characteristics, breed differences, and quality of life in North American dogs with acute steroid‐responsive meningitis‐arteritisJeanie Lau0Julie A. Nettifee1Peter J. Early2Christopher L. Mariani3Natasha J. Olby4Karen R. Muñana5Department of Clinical Sciences, College of Veterinary Medicine North Carolina State University Raleigh North CarolinaDepartment of Clinical Sciences, College of Veterinary Medicine North Carolina State University Raleigh North CarolinaDepartment of Clinical Sciences, College of Veterinary Medicine North Carolina State University Raleigh North CarolinaDepartment of Clinical Sciences, College of Veterinary Medicine North Carolina State University Raleigh North CarolinaDepartment of Clinical Sciences, College of Veterinary Medicine North Carolina State University Raleigh North CarolinaDepartment of Clinical Sciences, College of Veterinary Medicine North Carolina State University Raleigh North CarolinaAbstract Background Steroid‐responsive meningitis‐arteritis (SRMA) is a common inflammatory neurologic disorder of dogs for which certain breeds are predisposed. Objectives To determine whether breed differences exist in clinical features, treatment response, and relapse in a population of North American dogs with SRMA, and to evaluate the effect of disease on dogs' quality of life (QoL). Animals Sixty‐one client‐owned dogs with SRMA: 29 dogs identified through an American Kennel Club‐Canine Health Foundation survey and 32 dogs from North Carolina (NC) State Veterinary Hospital. Methods Retrospective case series. Caregivers completed an online survey to assess QoL. Results Breeds represented most often included the Golden Retriever (n = 12), Bernese Mountain Dog (10), Wirehaired Pointing Griffon (9), Boxer (9), and Beagle (6). No breed differences were identified with respect to clinical severity, diagnostic findings, or outcome. Twenty‐nine dogs (48%) had ≥1 disease relapse. There was a significant effect of cerebrospinal fluid nucleated cell count on the frequency of disease relapse (P = .003), but no relationship was identified between treatment protocol and relapse. Dogs' QoL was associated with the severity of corticosteroid‐related adverse effects (P = .03), which were dose‐related (r = .24, P = .02) and more prevalent in Wirehaired Pointing Griffons than in other breeds (P = .04). Conclusion and Clinical Importance Golden Retrievers and Wirehaired Pointing Griffons should be considered among the breeds recognized to develop SRMA. Treatment with higher corticosteroid dosages is correlated with more severe adverse effects and worse QoL, but it may not improve clinical outcome.https://doi.org/10.1111/jvim.15543aseptic meningitisCSF analysisimmune‐mediated diseasetreatment response |
| spellingShingle | Jeanie Lau Julie A. Nettifee Peter J. Early Christopher L. Mariani Natasha J. Olby Karen R. Muñana Clinical characteristics, breed differences, and quality of life in North American dogs with acute steroid‐responsive meningitis‐arteritis Journal of Veterinary Internal Medicine aseptic meningitis CSF analysis immune‐mediated disease treatment response |
| title | Clinical characteristics, breed differences, and quality of life in North American dogs with acute steroid‐responsive meningitis‐arteritis |
| title_full | Clinical characteristics, breed differences, and quality of life in North American dogs with acute steroid‐responsive meningitis‐arteritis |
| title_fullStr | Clinical characteristics, breed differences, and quality of life in North American dogs with acute steroid‐responsive meningitis‐arteritis |
| title_full_unstemmed | Clinical characteristics, breed differences, and quality of life in North American dogs with acute steroid‐responsive meningitis‐arteritis |
| title_short | Clinical characteristics, breed differences, and quality of life in North American dogs with acute steroid‐responsive meningitis‐arteritis |
| title_sort | clinical characteristics breed differences and quality of life in north american dogs with acute steroid responsive meningitis arteritis |
| topic | aseptic meningitis CSF analysis immune‐mediated disease treatment response |
| url | https://doi.org/10.1111/jvim.15543 |
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