Hypoglycemic effects of naturally processed Polygonum multiflorum extract in KK CgAy/J mice and its mechanism of action

ABSTRACT: In 2021, there are approximately 537 million adults ageing 2079 years affected by diabetes worldwide and the number is rising rapidly, hence it is important to manage and control diabetes mellitus and its associated complications. Food is one of the key factors in preventing and combating...

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Main Authors: Wenping Tang, Jianfeng Zhan, Shiming Li, Yue Liu, Chi-Tang Ho
Format: Article
Language:English
Published: Tsinghua University Press 2022-09-01
Series:Food Science and Human Wellness
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2213453022000519
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author Wenping Tang
Jianfeng Zhan
Shiming Li
Yue Liu
Chi-Tang Ho
author_facet Wenping Tang
Jianfeng Zhan
Shiming Li
Yue Liu
Chi-Tang Ho
author_sort Wenping Tang
collection DOAJ
description ABSTRACT: In 2021, there are approximately 537 million adults ageing 2079 years affected by diabetes worldwide and the number is rising rapidly, hence it is important to manage and control diabetes mellitus and its associated complications. Food is one of the key factors in preventing and combating diseases such as diabetes. Both as a food and an herbal medicine, Polygonum multiflorum (PM) has been used as an anti-aging tonic, for hair darkening in traditional Chinese medicine for several centuries. The recent research effort of PM has been focused on antioxidant, anti-ageing and anti-tumor properties. In the present study, we utilized the traditional processing of harvested raw PM, and identified several stilbene components and then evaluated the potential anti-diabetic effects of the processed PM extract (PME). PME (0.075 %) was given to diabetic mice (KK CgAy/J) in drinking water and after 7 weeks, PME-treated mice had significantly lower glucose levels than mice in the diabetic control group (P < 0.01). The mechanism was explored with ELISA and Western blotting and results suggested that the effect was through maintaining β-cell function.
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spelling doaj.art-2f5c61e109ae47b8bbbcbf345756bf792023-09-02T08:09:08ZengTsinghua University PressFood Science and Human Wellness2213-45302022-09-0111511771182Hypoglycemic effects of naturally processed Polygonum multiflorum extract in KK CgAy/J mice and its mechanism of actionWenping Tang0Jianfeng Zhan1Shiming Li2Yue Liu3Chi-Tang Ho4Hubei Key Laboratory of Economic Forest Germplasm Improvement and Resources Comprehensive Utilization, Huanggang Normal University, Huanggang 438000, China; Department of Food Science, Rutgers University, New Brunswick 08901, USAHubei Key Laboratory of Economic Forest Germplasm Improvement and Resources Comprehensive Utilization, Huanggang Normal University, Huanggang 438000, ChinaHubei Key Laboratory of Economic Forest Germplasm Improvement and Resources Comprehensive Utilization, Huanggang Normal University, Huanggang 438000, China; Corresponding authors.Department of Chemical Biology, Rutgers University, Piscataway 08901, USADepartment of Food Science, Rutgers University, New Brunswick 08901, USA; Corresponding authors.ABSTRACT: In 2021, there are approximately 537 million adults ageing 2079 years affected by diabetes worldwide and the number is rising rapidly, hence it is important to manage and control diabetes mellitus and its associated complications. Food is one of the key factors in preventing and combating diseases such as diabetes. Both as a food and an herbal medicine, Polygonum multiflorum (PM) has been used as an anti-aging tonic, for hair darkening in traditional Chinese medicine for several centuries. The recent research effort of PM has been focused on antioxidant, anti-ageing and anti-tumor properties. In the present study, we utilized the traditional processing of harvested raw PM, and identified several stilbene components and then evaluated the potential anti-diabetic effects of the processed PM extract (PME). PME (0.075 %) was given to diabetic mice (KK CgAy/J) in drinking water and after 7 weeks, PME-treated mice had significantly lower glucose levels than mice in the diabetic control group (P < 0.01). The mechanism was explored with ELISA and Western blotting and results suggested that the effect was through maintaining β-cell function.http://www.sciencedirect.com/science/article/pii/S2213453022000519DiabetesStilbene glycosidePolygonum multiflorumHypoglycemic activityHomeostatic model assessment
spellingShingle Wenping Tang
Jianfeng Zhan
Shiming Li
Yue Liu
Chi-Tang Ho
Hypoglycemic effects of naturally processed Polygonum multiflorum extract in KK CgAy/J mice and its mechanism of action
Food Science and Human Wellness
Diabetes
Stilbene glycoside
Polygonum multiflorum
Hypoglycemic activity
Homeostatic model assessment
title Hypoglycemic effects of naturally processed Polygonum multiflorum extract in KK CgAy/J mice and its mechanism of action
title_full Hypoglycemic effects of naturally processed Polygonum multiflorum extract in KK CgAy/J mice and its mechanism of action
title_fullStr Hypoglycemic effects of naturally processed Polygonum multiflorum extract in KK CgAy/J mice and its mechanism of action
title_full_unstemmed Hypoglycemic effects of naturally processed Polygonum multiflorum extract in KK CgAy/J mice and its mechanism of action
title_short Hypoglycemic effects of naturally processed Polygonum multiflorum extract in KK CgAy/J mice and its mechanism of action
title_sort hypoglycemic effects of naturally processed polygonum multiflorum extract in kk cgay j mice and its mechanism of action
topic Diabetes
Stilbene glycoside
Polygonum multiflorum
Hypoglycemic activity
Homeostatic model assessment
url http://www.sciencedirect.com/science/article/pii/S2213453022000519
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