Hypoglycemic effects of naturally processed Polygonum multiflorum extract in KK CgAy/J mice and its mechanism of action
ABSTRACT: In 2021, there are approximately 537 million adults ageing 2079 years affected by diabetes worldwide and the number is rising rapidly, hence it is important to manage and control diabetes mellitus and its associated complications. Food is one of the key factors in preventing and combating...
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Format: | Article |
Language: | English |
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Tsinghua University Press
2022-09-01
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Series: | Food Science and Human Wellness |
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Online Access: | http://www.sciencedirect.com/science/article/pii/S2213453022000519 |
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author | Wenping Tang Jianfeng Zhan Shiming Li Yue Liu Chi-Tang Ho |
author_facet | Wenping Tang Jianfeng Zhan Shiming Li Yue Liu Chi-Tang Ho |
author_sort | Wenping Tang |
collection | DOAJ |
description | ABSTRACT: In 2021, there are approximately 537 million adults ageing 2079 years affected by diabetes worldwide and the number is rising rapidly, hence it is important to manage and control diabetes mellitus and its associated complications. Food is one of the key factors in preventing and combating diseases such as diabetes. Both as a food and an herbal medicine, Polygonum multiflorum (PM) has been used as an anti-aging tonic, for hair darkening in traditional Chinese medicine for several centuries. The recent research effort of PM has been focused on antioxidant, anti-ageing and anti-tumor properties. In the present study, we utilized the traditional processing of harvested raw PM, and identified several stilbene components and then evaluated the potential anti-diabetic effects of the processed PM extract (PME). PME (0.075 %) was given to diabetic mice (KK CgAy/J) in drinking water and after 7 weeks, PME-treated mice had significantly lower glucose levels than mice in the diabetic control group (P < 0.01). The mechanism was explored with ELISA and Western blotting and results suggested that the effect was through maintaining β-cell function. |
first_indexed | 2024-03-12T10:40:33Z |
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institution | Directory Open Access Journal |
issn | 2213-4530 |
language | English |
last_indexed | 2024-03-12T10:40:33Z |
publishDate | 2022-09-01 |
publisher | Tsinghua University Press |
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series | Food Science and Human Wellness |
spelling | doaj.art-2f5c61e109ae47b8bbbcbf345756bf792023-09-02T08:09:08ZengTsinghua University PressFood Science and Human Wellness2213-45302022-09-0111511771182Hypoglycemic effects of naturally processed Polygonum multiflorum extract in KK CgAy/J mice and its mechanism of actionWenping Tang0Jianfeng Zhan1Shiming Li2Yue Liu3Chi-Tang Ho4Hubei Key Laboratory of Economic Forest Germplasm Improvement and Resources Comprehensive Utilization, Huanggang Normal University, Huanggang 438000, China; Department of Food Science, Rutgers University, New Brunswick 08901, USAHubei Key Laboratory of Economic Forest Germplasm Improvement and Resources Comprehensive Utilization, Huanggang Normal University, Huanggang 438000, ChinaHubei Key Laboratory of Economic Forest Germplasm Improvement and Resources Comprehensive Utilization, Huanggang Normal University, Huanggang 438000, China; Corresponding authors.Department of Chemical Biology, Rutgers University, Piscataway 08901, USADepartment of Food Science, Rutgers University, New Brunswick 08901, USA; Corresponding authors.ABSTRACT: In 2021, there are approximately 537 million adults ageing 2079 years affected by diabetes worldwide and the number is rising rapidly, hence it is important to manage and control diabetes mellitus and its associated complications. Food is one of the key factors in preventing and combating diseases such as diabetes. Both as a food and an herbal medicine, Polygonum multiflorum (PM) has been used as an anti-aging tonic, for hair darkening in traditional Chinese medicine for several centuries. The recent research effort of PM has been focused on antioxidant, anti-ageing and anti-tumor properties. In the present study, we utilized the traditional processing of harvested raw PM, and identified several stilbene components and then evaluated the potential anti-diabetic effects of the processed PM extract (PME). PME (0.075 %) was given to diabetic mice (KK CgAy/J) in drinking water and after 7 weeks, PME-treated mice had significantly lower glucose levels than mice in the diabetic control group (P < 0.01). The mechanism was explored with ELISA and Western blotting and results suggested that the effect was through maintaining β-cell function.http://www.sciencedirect.com/science/article/pii/S2213453022000519DiabetesStilbene glycosidePolygonum multiflorumHypoglycemic activityHomeostatic model assessment |
spellingShingle | Wenping Tang Jianfeng Zhan Shiming Li Yue Liu Chi-Tang Ho Hypoglycemic effects of naturally processed Polygonum multiflorum extract in KK CgAy/J mice and its mechanism of action Food Science and Human Wellness Diabetes Stilbene glycoside Polygonum multiflorum Hypoglycemic activity Homeostatic model assessment |
title | Hypoglycemic effects of naturally processed Polygonum multiflorum extract in KK CgAy/J mice and its mechanism of action |
title_full | Hypoglycemic effects of naturally processed Polygonum multiflorum extract in KK CgAy/J mice and its mechanism of action |
title_fullStr | Hypoglycemic effects of naturally processed Polygonum multiflorum extract in KK CgAy/J mice and its mechanism of action |
title_full_unstemmed | Hypoglycemic effects of naturally processed Polygonum multiflorum extract in KK CgAy/J mice and its mechanism of action |
title_short | Hypoglycemic effects of naturally processed Polygonum multiflorum extract in KK CgAy/J mice and its mechanism of action |
title_sort | hypoglycemic effects of naturally processed polygonum multiflorum extract in kk cgay j mice and its mechanism of action |
topic | Diabetes Stilbene glycoside Polygonum multiflorum Hypoglycemic activity Homeostatic model assessment |
url | http://www.sciencedirect.com/science/article/pii/S2213453022000519 |
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