Serum Probnp Associated with the Severity of Coronary Artery Disease: its Limitation in Metabolic Syndrome
Background and Objectives: Myocardial ischemia is the leading cause of mortality and morbidity in all over the world. Previous studies demonstrated that myocardial ischemic patients subjected to coronary angiograph were more likely to have significant high serum proBNP. This study aimed to assess...
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| Format: | Article |
| Language: | English |
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College of medicine/ University of Diyala
2019-11-01
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| Series: | Diyala Journal of Medicine |
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| Online Access: | http://djm.uodiyala.edu.iq/index.php/djm/article/view/397 |
| _version_ | 1797454751213813760 |
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| author | Adil Hassan Alhusseiny |
| author_facet | Adil Hassan Alhusseiny |
| author_sort | Adil Hassan Alhusseiny |
| collection | DOAJ |
| description |
Background and Objectives: Myocardial ischemia is the leading cause of mortality and morbidity in all over the world. Previous studies demonstrated that myocardial ischemic patients subjected to coronary angiograph were more likely to have significant high serum proBNP. This study aimed to assess the level of serum proBNP levels in myocardial ischemia patients who underwent coronary angiography and to relate the proBNP levels to the severity of coronary artery disease and the components of metabolic syndrome.
Methods: A total number of 128 patients admitted to the coronary angiography unit at Diyala Teaching Hospital in Diyala were recruited in the study. Indications of coronary angiography included; acute coronary syndrome, positive treadmill test, stable coronary artery disease and percutaneous coronary intervention. The severity of coronary artery disease was assessed by detecting the significant obstructed lesions in the number of obstructed vessels. Serum proBNP levels were measured after angiography.
Results: The results showed non-significant differences in the characteristics of patients and fasting serum lipids in different categories of vessels obstructed. Significant high serum proBNP levels were observed with increasing number of vessels obstructed and weren't related to the existence metabolic syndrome components. Serum proBNP levels were significantly and inversely correlated (r =0.5, p < 0.001) with ejection fraction of left ventricle.
Conclusions: Serum proBNP levels in myocardial ischemia patients are related directly to the severity of coronary artery diseases and inversely to the pumping function of the heart. Metabolic factors are not involved in significant high serum proBNP levels in myocardial ischemia patients
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| first_indexed | 2024-03-09T15:42:38Z |
| format | Article |
| id | doaj.art-2f5ce7f91fe74872af7475b58cbb67f2 |
| institution | Directory Open Access Journal |
| issn | 2219-9764 2617-8982 |
| language | English |
| last_indexed | 2024-03-09T15:42:38Z |
| publishDate | 2019-11-01 |
| publisher | College of medicine/ University of Diyala |
| record_format | Article |
| series | Diyala Journal of Medicine |
| spelling | doaj.art-2f5ce7f91fe74872af7475b58cbb67f22023-11-24T23:23:42ZengCollege of medicine/ University of DiyalaDiyala Journal of Medicine2219-97642617-89822019-11-0151Serum Probnp Associated with the Severity of Coronary Artery Disease: its Limitation in Metabolic SyndromeAdil Hassan Alhusseiny Background and Objectives: Myocardial ischemia is the leading cause of mortality and morbidity in all over the world. Previous studies demonstrated that myocardial ischemic patients subjected to coronary angiograph were more likely to have significant high serum proBNP. This study aimed to assess the level of serum proBNP levels in myocardial ischemia patients who underwent coronary angiography and to relate the proBNP levels to the severity of coronary artery disease and the components of metabolic syndrome. Methods: A total number of 128 patients admitted to the coronary angiography unit at Diyala Teaching Hospital in Diyala were recruited in the study. Indications of coronary angiography included; acute coronary syndrome, positive treadmill test, stable coronary artery disease and percutaneous coronary intervention. The severity of coronary artery disease was assessed by detecting the significant obstructed lesions in the number of obstructed vessels. Serum proBNP levels were measured after angiography. Results: The results showed non-significant differences in the characteristics of patients and fasting serum lipids in different categories of vessels obstructed. Significant high serum proBNP levels were observed with increasing number of vessels obstructed and weren't related to the existence metabolic syndrome components. Serum proBNP levels were significantly and inversely correlated (r =0.5, p < 0.001) with ejection fraction of left ventricle. Conclusions: Serum proBNP levels in myocardial ischemia patients are related directly to the severity of coronary artery diseases and inversely to the pumping function of the heart. Metabolic factors are not involved in significant high serum proBNP levels in myocardial ischemia patients http://djm.uodiyala.edu.iq/index.php/djm/article/view/397Pro brain natriuretic peptide, coronary artery disease, metabolic syndrome |
| spellingShingle | Adil Hassan Alhusseiny Serum Probnp Associated with the Severity of Coronary Artery Disease: its Limitation in Metabolic Syndrome Diyala Journal of Medicine Pro brain natriuretic peptide, coronary artery disease, metabolic syndrome |
| title | Serum Probnp Associated with the Severity of Coronary Artery Disease: its Limitation in Metabolic Syndrome |
| title_full | Serum Probnp Associated with the Severity of Coronary Artery Disease: its Limitation in Metabolic Syndrome |
| title_fullStr | Serum Probnp Associated with the Severity of Coronary Artery Disease: its Limitation in Metabolic Syndrome |
| title_full_unstemmed | Serum Probnp Associated with the Severity of Coronary Artery Disease: its Limitation in Metabolic Syndrome |
| title_short | Serum Probnp Associated with the Severity of Coronary Artery Disease: its Limitation in Metabolic Syndrome |
| title_sort | serum probnp associated with the severity of coronary artery disease its limitation in metabolic syndrome |
| topic | Pro brain natriuretic peptide, coronary artery disease, metabolic syndrome |
| url | http://djm.uodiyala.edu.iq/index.php/djm/article/view/397 |
| work_keys_str_mv | AT adilhassanalhusseiny serumprobnpassociatedwiththeseverityofcoronaryarterydiseaseitslimitationinmetabolicsyndrome |