Computer modelling and simulation of a novel printing head for complex tissue engineering constructs
In tissue engineering, three-dimensional functional scaffolds with tailored biological properties are needed to be able to mimic the hierarchical structure of biological tissues. Recent developments in additive biomanufacturing allow to extrude multiple materials enabling the fabrication of more sop...
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| Format: | Article |
| Language: | English |
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EDP Sciences
2020-01-01
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| Series: | MATEC Web of Conferences |
| Online Access: | https://www.matec-conferences.org/articles/matecconf/pdf/2020/14/matecconf_icmmen20_01045.pdf |
| _version_ | 1819142570408673280 |
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| author | Ates Gokhan |
| author_facet | Ates Gokhan |
| author_sort | Ates Gokhan |
| collection | DOAJ |
| description | In tissue engineering, three-dimensional functional scaffolds with tailored biological properties are needed to be able to mimic the hierarchical structure of biological tissues. Recent developments in additive biomanufacturing allow to extrude multiple materials enabling the fabrication of more sophisticated tissue constructs. These multi-material biomanufacturing systems comprise multiple printing heads through which individual materials are sequentially printed. Nevertheless, as more printing heads are added the fabrication process significantly decreases, since it requires mechanical switching among the physically separated printheads to enable printing multiple materials. In addition, this approach is not able to create biomimetic tissue constructs with property gradients. To address these limitations, this paper presents a novel static mixing extrusion printing head to enable the fabrication of multi-material, functionally graded structures using a single nozzle. Computational fluid dynamics (CFD) was used to numerically analyze the influence of Reynolds number on the flow pattern of biomaterials and mixing efficiency considering different miscible materials. |
| first_indexed | 2024-12-22T12:12:27Z |
| format | Article |
| id | doaj.art-2f5e0e918d6b40a79d7cf28818f74df3 |
| institution | Directory Open Access Journal |
| issn | 2261-236X |
| language | English |
| last_indexed | 2024-12-22T12:12:27Z |
| publishDate | 2020-01-01 |
| publisher | EDP Sciences |
| record_format | Article |
| series | MATEC Web of Conferences |
| spelling | doaj.art-2f5e0e918d6b40a79d7cf28818f74df32022-12-21T18:26:16ZengEDP SciencesMATEC Web of Conferences2261-236X2020-01-013180104510.1051/matecconf/202031801045matecconf_icmmen20_01045Computer modelling and simulation of a novel printing head for complex tissue engineering constructsAtes Gokhan0School of Mechanical, Aerospace and Civil Engineering, The University of ManchesterIn tissue engineering, three-dimensional functional scaffolds with tailored biological properties are needed to be able to mimic the hierarchical structure of biological tissues. Recent developments in additive biomanufacturing allow to extrude multiple materials enabling the fabrication of more sophisticated tissue constructs. These multi-material biomanufacturing systems comprise multiple printing heads through which individual materials are sequentially printed. Nevertheless, as more printing heads are added the fabrication process significantly decreases, since it requires mechanical switching among the physically separated printheads to enable printing multiple materials. In addition, this approach is not able to create biomimetic tissue constructs with property gradients. To address these limitations, this paper presents a novel static mixing extrusion printing head to enable the fabrication of multi-material, functionally graded structures using a single nozzle. Computational fluid dynamics (CFD) was used to numerically analyze the influence of Reynolds number on the flow pattern of biomaterials and mixing efficiency considering different miscible materials.https://www.matec-conferences.org/articles/matecconf/pdf/2020/14/matecconf_icmmen20_01045.pdf |
| spellingShingle | Ates Gokhan Computer modelling and simulation of a novel printing head for complex tissue engineering constructs MATEC Web of Conferences |
| title | Computer modelling and simulation of a novel printing head for complex tissue engineering constructs |
| title_full | Computer modelling and simulation of a novel printing head for complex tissue engineering constructs |
| title_fullStr | Computer modelling and simulation of a novel printing head for complex tissue engineering constructs |
| title_full_unstemmed | Computer modelling and simulation of a novel printing head for complex tissue engineering constructs |
| title_short | Computer modelling and simulation of a novel printing head for complex tissue engineering constructs |
| title_sort | computer modelling and simulation of a novel printing head for complex tissue engineering constructs |
| url | https://www.matec-conferences.org/articles/matecconf/pdf/2020/14/matecconf_icmmen20_01045.pdf |
| work_keys_str_mv | AT atesgokhan computermodellingandsimulationofanovelprintingheadforcomplextissueengineeringconstructs |