Nor-24-homoscalaranes, Neutrophilic Inflammatory Mediators from the Marine Sponge <i>Lendenfeldia</i> sp.
The marine sponge <i>Lendenfeldia</i> sp., collected from the Southern waters of Taiwan, was subjected to chemical composition screening, resulting in the isolation of four new 24-homoscalarane compounds, namely lendenfeldaranes R–U (<b>1</b>–<b>4</b>). The struct...
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MDPI AG
2023-09-01
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| Series: | Pharmaceuticals |
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| Online Access: | https://www.mdpi.com/1424-8247/16/9/1258 |
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| author | Bo-Rong Peng Li-Guo Zheng Lo-Yun Chen Mohamed El-Shazly Tsong-Long Hwang Jui-Hsin Su Mei-Hsien Lee Kuei-Hung Lai Ping-Jyun Sung |
| author_facet | Bo-Rong Peng Li-Guo Zheng Lo-Yun Chen Mohamed El-Shazly Tsong-Long Hwang Jui-Hsin Su Mei-Hsien Lee Kuei-Hung Lai Ping-Jyun Sung |
| author_sort | Bo-Rong Peng |
| collection | DOAJ |
| description | The marine sponge <i>Lendenfeldia</i> sp., collected from the Southern waters of Taiwan, was subjected to chemical composition screening, resulting in the isolation of four new 24-homoscalarane compounds, namely lendenfeldaranes R–U (<b>1</b>–<b>4</b>). The structures and relative stereochemistry of the new metabolites <b>1</b>–<b>4</b> were assigned based on NMR studies. The absolute configurations of compounds <b>1</b>–<b>4</b> were determined by comparing the calculated and experimental values of specific optical rotation. The antioxidant and anti-inflammatory activities of the isolated compounds were assayed using superoxide anion generation and elastase release assays. These assays are used to determine neutrophilic inflammatory responses of respiratory burst and degranulation. Compounds <b>2</b> and <b>4</b> inhibited superoxide anion generation by human neutrophils in response to formyl-L-methionyl-L-leucyl-L-phenylalanine/cytochalasin B (fMLP/CB) with IC<sub>50</sub>: 3.98–4.46 μM. Compounds <b>2</b> and <b>4</b> inhibited fMLP/CB-induced elastase release, with IC<sub>50</sub> values ranging from 4.73 to 5.24 μM. These findings suggested that these new 24-homoscalarane compounds possess unique structures and potential anti-inflammatory activity. |
| first_indexed | 2024-03-10T22:16:59Z |
| format | Article |
| id | doaj.art-2f5e892ebdef499f8aae2a781681c5e7 |
| institution | Directory Open Access Journal |
| issn | 1424-8247 |
| language | English |
| last_indexed | 2024-03-10T22:16:59Z |
| publishDate | 2023-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceuticals |
| spelling | doaj.art-2f5e892ebdef499f8aae2a781681c5e72023-11-19T12:24:48ZengMDPI AGPharmaceuticals1424-82472023-09-01169125810.3390/ph16091258Nor-24-homoscalaranes, Neutrophilic Inflammatory Mediators from the Marine Sponge <i>Lendenfeldia</i> sp.Bo-Rong Peng0Li-Guo Zheng1Lo-Yun Chen2Mohamed El-Shazly3Tsong-Long Hwang4Jui-Hsin Su5Mei-Hsien Lee6Kuei-Hung Lai7Ping-Jyun Sung8Graduate Institute of Pharmacognosy, College of Pharmacy, Taipei Medical University, Taipei 110301, TaiwanDoctoral Degree Program in Marine Biotechnology, National Sun Yat-sen University, Kaohsiung 804201, TaiwanGraduate Institute of Pharmacognosy, College of Pharmacy, Taipei Medical University, Taipei 110301, TaiwanDepartment of Pharmacognosy, Faculty of Pharmacy, Ain-Shams University, Organization of African Unity Street, Abassia, Cairo 11566, EgyptResearch Center for Chinese Herbal Medicine, College of Human Ecology, Chang Gung University of Science and Technology, Taoyuan 333324, TaiwanNational Museum of Marine Biology and Aquarium, Pingtung 944401, TaiwanGraduate Institute of Pharmacognosy, College of Pharmacy, Taipei Medical University, Taipei 110301, TaiwanGraduate Institute of Pharmacognosy, College of Pharmacy, Taipei Medical University, Taipei 110301, TaiwanNational Museum of Marine Biology and Aquarium, Pingtung 944401, TaiwanThe marine sponge <i>Lendenfeldia</i> sp., collected from the Southern waters of Taiwan, was subjected to chemical composition screening, resulting in the isolation of four new 24-homoscalarane compounds, namely lendenfeldaranes R–U (<b>1</b>–<b>4</b>). The structures and relative stereochemistry of the new metabolites <b>1</b>–<b>4</b> were assigned based on NMR studies. The absolute configurations of compounds <b>1</b>–<b>4</b> were determined by comparing the calculated and experimental values of specific optical rotation. The antioxidant and anti-inflammatory activities of the isolated compounds were assayed using superoxide anion generation and elastase release assays. These assays are used to determine neutrophilic inflammatory responses of respiratory burst and degranulation. Compounds <b>2</b> and <b>4</b> inhibited superoxide anion generation by human neutrophils in response to formyl-L-methionyl-L-leucyl-L-phenylalanine/cytochalasin B (fMLP/CB) with IC<sub>50</sub>: 3.98–4.46 μM. Compounds <b>2</b> and <b>4</b> inhibited fMLP/CB-induced elastase release, with IC<sub>50</sub> values ranging from 4.73 to 5.24 μM. These findings suggested that these new 24-homoscalarane compounds possess unique structures and potential anti-inflammatory activity.https://www.mdpi.com/1424-8247/16/9/1258marine sponge<i>Lendenfeldia</i> sp.scalaraneanti-inflammatoryneutrophil |
| spellingShingle | Bo-Rong Peng Li-Guo Zheng Lo-Yun Chen Mohamed El-Shazly Tsong-Long Hwang Jui-Hsin Su Mei-Hsien Lee Kuei-Hung Lai Ping-Jyun Sung Nor-24-homoscalaranes, Neutrophilic Inflammatory Mediators from the Marine Sponge <i>Lendenfeldia</i> sp. Pharmaceuticals marine sponge <i>Lendenfeldia</i> sp. scalarane anti-inflammatory neutrophil |
| title | Nor-24-homoscalaranes, Neutrophilic Inflammatory Mediators from the Marine Sponge <i>Lendenfeldia</i> sp. |
| title_full | Nor-24-homoscalaranes, Neutrophilic Inflammatory Mediators from the Marine Sponge <i>Lendenfeldia</i> sp. |
| title_fullStr | Nor-24-homoscalaranes, Neutrophilic Inflammatory Mediators from the Marine Sponge <i>Lendenfeldia</i> sp. |
| title_full_unstemmed | Nor-24-homoscalaranes, Neutrophilic Inflammatory Mediators from the Marine Sponge <i>Lendenfeldia</i> sp. |
| title_short | Nor-24-homoscalaranes, Neutrophilic Inflammatory Mediators from the Marine Sponge <i>Lendenfeldia</i> sp. |
| title_sort | nor 24 homoscalaranes neutrophilic inflammatory mediators from the marine sponge i lendenfeldia i sp |
| topic | marine sponge <i>Lendenfeldia</i> sp. scalarane anti-inflammatory neutrophil |
| url | https://www.mdpi.com/1424-8247/16/9/1258 |
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