Application and investigation of thrombopoiesis-stimulating agents in the treatment of thrombocytopenia
Platelets, derived from a certain subpopulation of megakaryocytes, are closely related to hemostasis, coagulation, metastasis, inflammation, and cancer progression. Thrombopoiesis is a dynamic process regulated by various signaling pathways in which thrombopoietin (THPO)–MPL is dominant. Thrombopoie...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2023-02-01
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| Series: | Therapeutic Advances in Hematology |
| Online Access: | https://doi.org/10.1177/20406207231152746 |
| _version_ | 1797894110855561216 |
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| author | Lejun Huang Jianxuan Xu Huaying Zhang Mengfan Wang Yiyue Zhang Qing Lin |
| author_facet | Lejun Huang Jianxuan Xu Huaying Zhang Mengfan Wang Yiyue Zhang Qing Lin |
| author_sort | Lejun Huang |
| collection | DOAJ |
| description | Platelets, derived from a certain subpopulation of megakaryocytes, are closely related to hemostasis, coagulation, metastasis, inflammation, and cancer progression. Thrombopoiesis is a dynamic process regulated by various signaling pathways in which thrombopoietin (THPO)–MPL is dominant. Thrombopoiesis-stimulating agents could promote platelet production, showing therapeutic effects in different kinds of thrombocytopenia. Some thrombopoiesis-stimulating agents are currently used in clinical practices to treat thrombocytopenia. The others are not in clinical investigations to deal with thrombocytopenia but have potential in thrombopoiesis. Their potential values in thrombocytopenia treatment should be highly regarded. Novel drug screening models and drug repurposing research have found many new agents and yielded promising outcomes in preclinical or clinical studies. This review will briefly introduce thrombopoiesis-stimulating agents currently or potentially valuable in thrombocytopenia treatment and summarize the possible mechanisms and therapeutic effects, which may enrich the pharmacological armamentarium for the medical treatment of thrombocytopenia. |
| first_indexed | 2024-04-10T07:03:38Z |
| format | Article |
| id | doaj.art-2f5f1c2eec344e5da3c44dc8abb7179b |
| institution | Directory Open Access Journal |
| issn | 2040-6215 |
| language | English |
| last_indexed | 2024-04-10T07:03:38Z |
| publishDate | 2023-02-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Therapeutic Advances in Hematology |
| spelling | doaj.art-2f5f1c2eec344e5da3c44dc8abb7179b2023-02-27T10:33:37ZengSAGE PublishingTherapeutic Advances in Hematology2040-62152023-02-011410.1177/20406207231152746Application and investigation of thrombopoiesis-stimulating agents in the treatment of thrombocytopeniaLejun HuangJianxuan XuHuaying ZhangMengfan WangYiyue ZhangQing LinPlatelets, derived from a certain subpopulation of megakaryocytes, are closely related to hemostasis, coagulation, metastasis, inflammation, and cancer progression. Thrombopoiesis is a dynamic process regulated by various signaling pathways in which thrombopoietin (THPO)–MPL is dominant. Thrombopoiesis-stimulating agents could promote platelet production, showing therapeutic effects in different kinds of thrombocytopenia. Some thrombopoiesis-stimulating agents are currently used in clinical practices to treat thrombocytopenia. The others are not in clinical investigations to deal with thrombocytopenia but have potential in thrombopoiesis. Their potential values in thrombocytopenia treatment should be highly regarded. Novel drug screening models and drug repurposing research have found many new agents and yielded promising outcomes in preclinical or clinical studies. This review will briefly introduce thrombopoiesis-stimulating agents currently or potentially valuable in thrombocytopenia treatment and summarize the possible mechanisms and therapeutic effects, which may enrich the pharmacological armamentarium for the medical treatment of thrombocytopenia.https://doi.org/10.1177/20406207231152746 |
| spellingShingle | Lejun Huang Jianxuan Xu Huaying Zhang Mengfan Wang Yiyue Zhang Qing Lin Application and investigation of thrombopoiesis-stimulating agents in the treatment of thrombocytopenia Therapeutic Advances in Hematology |
| title | Application and investigation of thrombopoiesis-stimulating agents in the treatment of thrombocytopenia |
| title_full | Application and investigation of thrombopoiesis-stimulating agents in the treatment of thrombocytopenia |
| title_fullStr | Application and investigation of thrombopoiesis-stimulating agents in the treatment of thrombocytopenia |
| title_full_unstemmed | Application and investigation of thrombopoiesis-stimulating agents in the treatment of thrombocytopenia |
| title_short | Application and investigation of thrombopoiesis-stimulating agents in the treatment of thrombocytopenia |
| title_sort | application and investigation of thrombopoiesis stimulating agents in the treatment of thrombocytopenia |
| url | https://doi.org/10.1177/20406207231152746 |
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