Association of Essential Tremor With Dementia and Affective Disorders: A Meta-Analysis
BackgroundThe dementia and affective disorders are common non-motor features in patients with essential tremor (ET). However, the relationship of ET with cognitive impairments and affective disorders remains controversial. This meta-analysis aimed to analyze the association of ET with dementia and a...
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| Format: | Article |
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Frontiers Media S.A.
2022-03-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2022.842732/full |
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| author | Yajun Shang Yajun Shang Xinjie Chen Xinjie Chen Mingda Ai Mingda Ai Xiaoran Gao Shujuan Dai Shujuan Dai Mingjie Zhao Mingjie Zhao Cen Yang Liangfeng Wang Junyan Zhang Lianmei Zhong Lianmei Zhong Tianhao Bao Tianhao Bao Xiaolei Liu Xiaolei Liu |
| author_facet | Yajun Shang Yajun Shang Xinjie Chen Xinjie Chen Mingda Ai Mingda Ai Xiaoran Gao Shujuan Dai Shujuan Dai Mingjie Zhao Mingjie Zhao Cen Yang Liangfeng Wang Junyan Zhang Lianmei Zhong Lianmei Zhong Tianhao Bao Tianhao Bao Xiaolei Liu Xiaolei Liu |
| author_sort | Yajun Shang |
| collection | DOAJ |
| description | BackgroundThe dementia and affective disorders are common non-motor features in patients with essential tremor (ET). However, the relationship of ET with cognitive impairments and affective disorders remains controversial. This meta-analysis aimed to analyze the association of ET with dementia and affective disorders.MethodsOriginal studies published from January 1999 to October 2019 were systematically searched from the database of Medline (OvidSP), EMBASE (OvidSP), and the Cochrane Central Register of Controlled Trials. Pooled standard mean difference (SMD, random effect model), odds ratios (ORs), relative risk (RR), and 95% CI were calculated.ResultsCompared with the Non-ET group, patients with ET had significantly lower Mini-Mental State Examination (MMSE) score (SMD, −1.16; 95% CI, −1.75 to −0.58; p = 0.0001) and had significantly higher depressive and anxiety symptoms scale score (SMD, 0.55; 95% CI, 0.22–0.87; p = 0.0009). The OR for dementia and affective disorders in individuals with ET compared with individuals without ET was 2.49 (95% CI, 2.17–2.85, p < 0.00001). While there was no significant difference in Montreal Cognitive Assessment (MoCA) score between ET and Non-ET groups (SMD, −0.52; 95% CI, −0.16 to 0.13; p = 0.23), there was a significant difference in the risk of mortality between ET and Non-ET groups (RR = 4.69, 95% CI, 2.18–10.07).ConclusionThe non-motor symptoms should not be neglected among patients with ET. However, the causal relationship between ET and dementia, depression, and anxiety is unclear. |
| first_indexed | 2024-12-13T02:23:53Z |
| format | Article |
| id | doaj.art-2f5f40c6ee95410ca145237cf5cc86bb |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-12-13T02:23:53Z |
| publishDate | 2022-03-01 |
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| series | Frontiers in Neurology |
| spelling | doaj.art-2f5f40c6ee95410ca145237cf5cc86bb2022-12-22T00:02:41ZengFrontiers Media S.A.Frontiers in Neurology1664-22952022-03-011310.3389/fneur.2022.842732842732Association of Essential Tremor With Dementia and Affective Disorders: A Meta-AnalysisYajun Shang0Yajun Shang1Xinjie Chen2Xinjie Chen3Mingda Ai4Mingda Ai5Xiaoran Gao6Shujuan Dai7Shujuan Dai8Mingjie Zhao9Mingjie Zhao10Cen Yang11Liangfeng Wang12Junyan Zhang13Lianmei Zhong14Lianmei Zhong15Tianhao Bao16Tianhao Bao17Xiaolei Liu18Xiaolei Liu19Department of Neurosurgery, The First Affiliated Hospital of Kunming Medical University, Kunming, ChinaYunnan Provincial Clinical Research Center for Neurological Diseases, Kunming, ChinaYunnan Provincial Clinical Research Center for Neurological Diseases, Kunming, ChinaDepartment of Neurology, The First Affiliated Hospital of Dali University, Dali, ChinaYunnan Provincial Clinical Research Center for Neurological Diseases, Kunming, ChinaDepartment of Neurology, The First Affiliated Hospital of Kunming Medical University, Kunming, ChinaDepartment of Surgery, Shenzhen University, Shenzhen, ChinaYunnan Provincial Clinical Research Center for Neurological Diseases, Kunming, ChinaDepartment of Neurology, The First Affiliated Hospital of Kunming Medical University, Kunming, ChinaYunnan Provincial Clinical Research Center for Neurological Diseases, Kunming, ChinaDepartment of Neurology, The First Affiliated Hospital of Kunming Medical University, Kunming, ChinaDepartment of Surgery, Shenzhen University, Shenzhen, ChinaDepartment of Anesthesiology, The First Clinical Medical College of Kunming Medical University, Kunming, ChinaBothwin Clinical Study Consultant, Shanghai, ChinaYunnan Provincial Clinical Research Center for Neurological Diseases, Kunming, ChinaDepartment of Neurology, The First Affiliated Hospital of Kunming Medical University, Kunming, ChinaDepartment of Geriatrics, Kunming Medical University Affiliated Mental Health Center, Kunming, ChinaWest China Hospital, Sichuan University, Chengdu, ChinaYunnan Provincial Clinical Research Center for Neurological Diseases, Kunming, ChinaDepartment of Neurology, The First Affiliated Hospital of Kunming Medical University, Kunming, ChinaBackgroundThe dementia and affective disorders are common non-motor features in patients with essential tremor (ET). However, the relationship of ET with cognitive impairments and affective disorders remains controversial. This meta-analysis aimed to analyze the association of ET with dementia and affective disorders.MethodsOriginal studies published from January 1999 to October 2019 were systematically searched from the database of Medline (OvidSP), EMBASE (OvidSP), and the Cochrane Central Register of Controlled Trials. Pooled standard mean difference (SMD, random effect model), odds ratios (ORs), relative risk (RR), and 95% CI were calculated.ResultsCompared with the Non-ET group, patients with ET had significantly lower Mini-Mental State Examination (MMSE) score (SMD, −1.16; 95% CI, −1.75 to −0.58; p = 0.0001) and had significantly higher depressive and anxiety symptoms scale score (SMD, 0.55; 95% CI, 0.22–0.87; p = 0.0009). The OR for dementia and affective disorders in individuals with ET compared with individuals without ET was 2.49 (95% CI, 2.17–2.85, p < 0.00001). While there was no significant difference in Montreal Cognitive Assessment (MoCA) score between ET and Non-ET groups (SMD, −0.52; 95% CI, −0.16 to 0.13; p = 0.23), there was a significant difference in the risk of mortality between ET and Non-ET groups (RR = 4.69, 95% CI, 2.18–10.07).ConclusionThe non-motor symptoms should not be neglected among patients with ET. However, the causal relationship between ET and dementia, depression, and anxiety is unclear.https://www.frontiersin.org/articles/10.3389/fneur.2022.842732/fullanxietydementiaessential tremordepressionmovement disorders |
| spellingShingle | Yajun Shang Yajun Shang Xinjie Chen Xinjie Chen Mingda Ai Mingda Ai Xiaoran Gao Shujuan Dai Shujuan Dai Mingjie Zhao Mingjie Zhao Cen Yang Liangfeng Wang Junyan Zhang Lianmei Zhong Lianmei Zhong Tianhao Bao Tianhao Bao Xiaolei Liu Xiaolei Liu Association of Essential Tremor With Dementia and Affective Disorders: A Meta-Analysis Frontiers in Neurology anxiety dementia essential tremor depression movement disorders |
| title | Association of Essential Tremor With Dementia and Affective Disorders: A Meta-Analysis |
| title_full | Association of Essential Tremor With Dementia and Affective Disorders: A Meta-Analysis |
| title_fullStr | Association of Essential Tremor With Dementia and Affective Disorders: A Meta-Analysis |
| title_full_unstemmed | Association of Essential Tremor With Dementia and Affective Disorders: A Meta-Analysis |
| title_short | Association of Essential Tremor With Dementia and Affective Disorders: A Meta-Analysis |
| title_sort | association of essential tremor with dementia and affective disorders a meta analysis |
| topic | anxiety dementia essential tremor depression movement disorders |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2022.842732/full |
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