Frequency and prognostic significance of hypercalcemia in patients with multiple myeloma
Background: Multiple myeloma (MM) is defined as a clonal B-cell malignancy of the bone marrow. Hypercalcemia is associated with cancers in general and in MM specifically becomes more obvious with frequent adverse outcomes. Objectives: The objective is to determine the frequency of hypercalcemia in M...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2020-01-01
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| Series: | Medical Journal of Babylon |
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| Online Access: | http://www.medjbabylon.org/article.asp?issn=1812-156X;year=2020;volume=17;issue=4;spage=327;epage=331;aulast=Karim |
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| author | Kanar J Karim Abid M Hassan Hisham A Getta Najmaddin S. H. Khoshnaw Sana D Jalal Akram M Mohammed Kawa M Hasan Dana A Abdullah Ameer I A. Badi Ahmed K Yassin Banaz M Safar Basil K Abdulla Rawand P Shamoon Truska A Amin Zeki A Mohamed Ali I Mohammed Diveen J Hussein Nawsherwan S Mohammed Rezhin N Rajab Firiad Hiwaizi |
| author_facet | Kanar J Karim Abid M Hassan Hisham A Getta Najmaddin S. H. Khoshnaw Sana D Jalal Akram M Mohammed Kawa M Hasan Dana A Abdullah Ameer I A. Badi Ahmed K Yassin Banaz M Safar Basil K Abdulla Rawand P Shamoon Truska A Amin Zeki A Mohamed Ali I Mohammed Diveen J Hussein Nawsherwan S Mohammed Rezhin N Rajab Firiad Hiwaizi |
| author_sort | Kanar J Karim |
| collection | DOAJ |
| description | Background: Multiple myeloma (MM) is defined as a clonal B-cell malignancy of the bone marrow. Hypercalcemia is associated with cancers in general and in MM specifically becomes more obvious with frequent adverse outcomes. Objectives: The objective is to determine the frequency of hypercalcemia in MM patients and survival rate after 3 years of diagnosis with the assessment of relationship between MM prognosis and hypercalcemia. Materials and Methods: Retrospective data were reviewed from the Hematology and Cancer Centers of Kurdistan Region of Iraq (KRI, Erbil, Sulaymaniyah, and Duhok) from January 2012 to December 2017 on a sample of 130 patients with MM. The diagnosis of MM and hypercalcemia was done according to the International Myeloma Working Group definition of MM and serum calcium of ≥11 mg/dl. Results: The prevalence of hypercalcemia among MM patients after calcium correction was 17.7%. Serum creatinine level is significantly higher among MM patients with hypercalcemia. There was a significant association between high death rates and MM patients with hypercalcemia. The mean survival of MM patients was 4.5 years and 72% of the MM patients had 3-year survival, which decreased to <41% for 6-year survival. The survival of MM patients with hypercalcemia was significantly shorter than survival of patients without hypercalcemia. Conclusions: The frequency of hypercalcemia among MM patients in KRI is within the international acceptable range and is regarded as a poor prognostic factor that is associated with higher mortality and shorter survival. |
| first_indexed | 2024-12-14T12:25:50Z |
| format | Article |
| id | doaj.art-2f60ea09aad24026ad4a6d697266ed20 |
| institution | Directory Open Access Journal |
| issn | 1812-156X 2312-6760 |
| language | English |
| last_indexed | 2024-12-14T12:25:50Z |
| publishDate | 2020-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Medical Journal of Babylon |
| spelling | doaj.art-2f60ea09aad24026ad4a6d697266ed202022-12-21T23:01:19ZengWolters Kluwer Medknow PublicationsMedical Journal of Babylon1812-156X2312-67602020-01-0117432733110.4103/MJBL.MJBL_54_20Frequency and prognostic significance of hypercalcemia in patients with multiple myelomaKanar J KarimAbid M HassanHisham A GettaNajmaddin S. H. KhoshnawSana D JalalAkram M MohammedKawa M HasanDana A AbdullahAmeer I A. BadiAhmed K YassinBanaz M SafarBasil K AbdullaRawand P ShamoonTruska A AminZeki A MohamedAli I MohammedDiveen J HusseinNawsherwan S MohammedRezhin N RajabFiriad HiwaiziBackground: Multiple myeloma (MM) is defined as a clonal B-cell malignancy of the bone marrow. Hypercalcemia is associated with cancers in general and in MM specifically becomes more obvious with frequent adverse outcomes. Objectives: The objective is to determine the frequency of hypercalcemia in MM patients and survival rate after 3 years of diagnosis with the assessment of relationship between MM prognosis and hypercalcemia. Materials and Methods: Retrospective data were reviewed from the Hematology and Cancer Centers of Kurdistan Region of Iraq (KRI, Erbil, Sulaymaniyah, and Duhok) from January 2012 to December 2017 on a sample of 130 patients with MM. The diagnosis of MM and hypercalcemia was done according to the International Myeloma Working Group definition of MM and serum calcium of ≥11 mg/dl. Results: The prevalence of hypercalcemia among MM patients after calcium correction was 17.7%. Serum creatinine level is significantly higher among MM patients with hypercalcemia. There was a significant association between high death rates and MM patients with hypercalcemia. The mean survival of MM patients was 4.5 years and 72% of the MM patients had 3-year survival, which decreased to <41% for 6-year survival. The survival of MM patients with hypercalcemia was significantly shorter than survival of patients without hypercalcemia. Conclusions: The frequency of hypercalcemia among MM patients in KRI is within the international acceptable range and is regarded as a poor prognostic factor that is associated with higher mortality and shorter survival.http://www.medjbabylon.org/article.asp?issn=1812-156X;year=2020;volume=17;issue=4;spage=327;epage=331;aulast=Karimhypercalcemiamultiple myelomasurvival |
| spellingShingle | Kanar J Karim Abid M Hassan Hisham A Getta Najmaddin S. H. Khoshnaw Sana D Jalal Akram M Mohammed Kawa M Hasan Dana A Abdullah Ameer I A. Badi Ahmed K Yassin Banaz M Safar Basil K Abdulla Rawand P Shamoon Truska A Amin Zeki A Mohamed Ali I Mohammed Diveen J Hussein Nawsherwan S Mohammed Rezhin N Rajab Firiad Hiwaizi Frequency and prognostic significance of hypercalcemia in patients with multiple myeloma Medical Journal of Babylon hypercalcemia multiple myeloma survival |
| title | Frequency and prognostic significance of hypercalcemia in patients with multiple myeloma |
| title_full | Frequency and prognostic significance of hypercalcemia in patients with multiple myeloma |
| title_fullStr | Frequency and prognostic significance of hypercalcemia in patients with multiple myeloma |
| title_full_unstemmed | Frequency and prognostic significance of hypercalcemia in patients with multiple myeloma |
| title_short | Frequency and prognostic significance of hypercalcemia in patients with multiple myeloma |
| title_sort | frequency and prognostic significance of hypercalcemia in patients with multiple myeloma |
| topic | hypercalcemia multiple myeloma survival |
| url | http://www.medjbabylon.org/article.asp?issn=1812-156X;year=2020;volume=17;issue=4;spage=327;epage=331;aulast=Karim |
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