Associations between primary motor cortex organization, motor control and sensory tests during the clinical course of low back pain. A protocol for a cross-sectional and longitudinal case-control study
Background: In people with low back pain (LBP), altered motor control has been related to reorganization of the primary motor cortex (M1). Sensory impairments in LBP have also been suggested to be associated with reorganization of M1. Little is known about reorganization of M1 over time in people wi...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-12-01
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| Series: | Contemporary Clinical Trials Communications |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2451865422001399 |
| _version_ | 1811295638297509888 |
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| author | Sabrine P. Klerx Sjoerd M. Bruijn Henri Kiers Michel W. Coppieters Jos W.R. Twisk Annelies L. Pool-Goudzwaard |
| author_facet | Sabrine P. Klerx Sjoerd M. Bruijn Henri Kiers Michel W. Coppieters Jos W.R. Twisk Annelies L. Pool-Goudzwaard |
| author_sort | Sabrine P. Klerx |
| collection | DOAJ |
| description | Background: In people with low back pain (LBP), altered motor control has been related to reorganization of the primary motor cortex (M1). Sensory impairments in LBP have also been suggested to be associated with reorganization of M1. Little is known about reorganization of M1 over time in people with LBP, and whether it relates to changes in motor control and sensory impairments and recovery. This study aims to investigate 1) differences in organization of M1 of trunk muscles between people with and without LBP, and whether the organization of M1 relates to motor control and sensory impairments (cross-sectional component) and 2) reorganization of M1 over time and its relation with changes in motor control and sensory impairments and experienced recovery (longitudinal component). Methods: A case-control study with a cross-sectional and five-week longitudinal component is conducted in participants with LBP (N = 25) and participants without LBP (N = 25). Participants with LBP received usual care physiotherapy. Various tests were administered at baseline and follow-up. Following an anatomical MRI, organization of M1 (Center of Gravity and Area of the cortical representation of trunk muscles) was determined using transcranial magnetic stimulation. Quantitative sensory testing, a spiral-tracking motor control test, graphesthesia, two-point discrimination threshold and various self-reported questionnaires were also assessed. Multivariate multilevel analysis will be used for statistical analysis. Conclusion: We will address the gaps in knowledge about the association between reorganization of M1 and motor control and sensory tests during the clinical course of LBP. This study is registered at DOI 10.17605/OSF.IO/5C8ZG. |
| first_indexed | 2024-04-13T05:35:34Z |
| format | Article |
| id | doaj.art-2f613f53933e49049bef8dc6c3d63aac |
| institution | Directory Open Access Journal |
| issn | 2451-8654 |
| language | English |
| last_indexed | 2024-04-13T05:35:34Z |
| publishDate | 2022-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Contemporary Clinical Trials Communications |
| spelling | doaj.art-2f613f53933e49049bef8dc6c3d63aac2022-12-22T03:00:17ZengElsevierContemporary Clinical Trials Communications2451-86542022-12-0130101022Associations between primary motor cortex organization, motor control and sensory tests during the clinical course of low back pain. A protocol for a cross-sectional and longitudinal case-control studySabrine P. Klerx0Sjoerd M. Bruijn1Henri Kiers2Michel W. Coppieters3Jos W.R. Twisk4Annelies L. Pool-Goudzwaard5Faculty of Behavioral and Movement Sciences, Vrije Universiteit Amsterdam, Amsterdam Movement Sciences, Amsterdam, the Netherlands; Research Group Lifestyle and Health, Section Movement Adaptation and Prognosis, HU University of Applied Sciences, Utrecht, the Netherlands; Corresponding author. Department of Human Movement Sciences, Faculty of Behavioral and Movement Sciences, Vrije Universiteit Amsterdam, Van der Boechorststraat 7, 1081 BT, Amsterdam, the Netherlands.Faculty of Behavioral and Movement Sciences, Vrije Universiteit Amsterdam, Amsterdam Movement Sciences, Amsterdam, the Netherlands; Institute of Brain and Behavior, Amsterdam, the NetherlandsFaculty of Behavioral and Movement Sciences, Vrije Universiteit Amsterdam, Amsterdam Movement Sciences, Amsterdam, the Netherlands; Research Group Lifestyle and Health, Section Movement Adaptation and Prognosis, HU University of Applied Sciences, Utrecht, the NetherlandsFaculty of Behavioral and Movement Sciences, Vrije Universiteit Amsterdam, Amsterdam Movement Sciences, Amsterdam, the Netherlands; Menzies Health Institute Queensland, Griffith University, Brisbane and Gold Coast, AustraliaDepartment of Epidemiology and Data Science, Amsterdam University Medical Centre, Amsterdam, the NetherlandsFaculty of Behavioral and Movement Sciences, Vrije Universiteit Amsterdam, Amsterdam Movement Sciences, Amsterdam, the Netherlands; SOMT University of Physiotherapy, Amersfoort, the NetherlandsBackground: In people with low back pain (LBP), altered motor control has been related to reorganization of the primary motor cortex (M1). Sensory impairments in LBP have also been suggested to be associated with reorganization of M1. Little is known about reorganization of M1 over time in people with LBP, and whether it relates to changes in motor control and sensory impairments and recovery. This study aims to investigate 1) differences in organization of M1 of trunk muscles between people with and without LBP, and whether the organization of M1 relates to motor control and sensory impairments (cross-sectional component) and 2) reorganization of M1 over time and its relation with changes in motor control and sensory impairments and experienced recovery (longitudinal component). Methods: A case-control study with a cross-sectional and five-week longitudinal component is conducted in participants with LBP (N = 25) and participants without LBP (N = 25). Participants with LBP received usual care physiotherapy. Various tests were administered at baseline and follow-up. Following an anatomical MRI, organization of M1 (Center of Gravity and Area of the cortical representation of trunk muscles) was determined using transcranial magnetic stimulation. Quantitative sensory testing, a spiral-tracking motor control test, graphesthesia, two-point discrimination threshold and various self-reported questionnaires were also assessed. Multivariate multilevel analysis will be used for statistical analysis. Conclusion: We will address the gaps in knowledge about the association between reorganization of M1 and motor control and sensory tests during the clinical course of LBP. This study is registered at DOI 10.17605/OSF.IO/5C8ZG.http://www.sciencedirect.com/science/article/pii/S2451865422001399Low back painTranscranial magnetic stimulationCortical organizationMotor controlSensory tests |
| spellingShingle | Sabrine P. Klerx Sjoerd M. Bruijn Henri Kiers Michel W. Coppieters Jos W.R. Twisk Annelies L. Pool-Goudzwaard Associations between primary motor cortex organization, motor control and sensory tests during the clinical course of low back pain. A protocol for a cross-sectional and longitudinal case-control study Contemporary Clinical Trials Communications Low back pain Transcranial magnetic stimulation Cortical organization Motor control Sensory tests |
| title | Associations between primary motor cortex organization, motor control and sensory tests during the clinical course of low back pain. A protocol for a cross-sectional and longitudinal case-control study |
| title_full | Associations between primary motor cortex organization, motor control and sensory tests during the clinical course of low back pain. A protocol for a cross-sectional and longitudinal case-control study |
| title_fullStr | Associations between primary motor cortex organization, motor control and sensory tests during the clinical course of low back pain. A protocol for a cross-sectional and longitudinal case-control study |
| title_full_unstemmed | Associations between primary motor cortex organization, motor control and sensory tests during the clinical course of low back pain. A protocol for a cross-sectional and longitudinal case-control study |
| title_short | Associations between primary motor cortex organization, motor control and sensory tests during the clinical course of low back pain. A protocol for a cross-sectional and longitudinal case-control study |
| title_sort | associations between primary motor cortex organization motor control and sensory tests during the clinical course of low back pain a protocol for a cross sectional and longitudinal case control study |
| topic | Low back pain Transcranial magnetic stimulation Cortical organization Motor control Sensory tests |
| url | http://www.sciencedirect.com/science/article/pii/S2451865422001399 |
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