Antioxidants and the risk of stroke: results from NHANES and two-sample Mendelian randomization study
Abstract Background Stroke is the second leading cause of death worldwide, and observational studies have suggested a correlation between antioxidants and reduced stroke risk. However, it remains unclear whether causal relationships exist. Methods This study first performed a cross-sectional study o...
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BMC
2024-01-01
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Series: | European Journal of Medical Research |
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Online Access: | https://doi.org/10.1186/s40001-024-01646-5 |
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author | Rundong Chen Hanchen Liu Guanghao Zhang Qian Zhang Weilong Hua Lei Zhang Nan Lv Yilei Zhang Dongwei Dai Rui Zhao Qiang Li Qinghai Huang Yi Xu Pengfei Yang Jianmin Liu Qiao Zuo |
author_facet | Rundong Chen Hanchen Liu Guanghao Zhang Qian Zhang Weilong Hua Lei Zhang Nan Lv Yilei Zhang Dongwei Dai Rui Zhao Qiang Li Qinghai Huang Yi Xu Pengfei Yang Jianmin Liu Qiao Zuo |
author_sort | Rundong Chen |
collection | DOAJ |
description | Abstract Background Stroke is the second leading cause of death worldwide, and observational studies have suggested a correlation between antioxidants and reduced stroke risk. However, it remains unclear whether causal relationships exist. Methods This study first performed a cross-sectional study of the association between the Composite Dietary Antioxidant Index (CDAI) and stroke using data from the National Health and Nutrition Examination Survey (NHANES) 2007–2018. Second, a two-sample univariable Mendelian Randomization (MR) was performed to analyze the causal effect of circulating levels of antioxidants on different subtypes of stroke. Results The cross-sectional study included a total of 24,892 participants representing more than 200 million US non-institutionalized residents, a multivariable logistic regression model revealed that the risk of stroke decreased by 3.4% for each unit increase in CDAI (P = 0.017), with a non-linear association found, indicating a reduction in stroke risk before an inflection point of 3.078. MR analysis revealed that genetically determined levels of retinol had a suggestive protective effect on subarachnoid hemorrhage (SAH) (OR = 0.348, P = 0.025), and genetically determined levels of selenium had a suggestive protective effect against SAH (OR = 0.826, P = 0.007). However, no causal relationship was found between antioxidants and ischemic stroke or intracranial hemorrhage risk. Conclusions Evidence suggests that diet-derived antioxidants may reduce the risk of stroke, as indicated by the protective effects of retinol and selenium against SAH. However, more research is needed to fully understand how antioxidants prevent stroke. |
first_indexed | 2024-03-08T14:17:56Z |
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language | English |
last_indexed | 2024-03-08T14:17:56Z |
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series | European Journal of Medical Research |
spelling | doaj.art-2f69255f920d4b389fe8b34393e1e8632024-01-14T12:16:33ZengBMCEuropean Journal of Medical Research2047-783X2024-01-0129111210.1186/s40001-024-01646-5Antioxidants and the risk of stroke: results from NHANES and two-sample Mendelian randomization studyRundong Chen0Hanchen Liu1Guanghao Zhang2Qian Zhang3Weilong Hua4Lei Zhang5Nan Lv6Yilei Zhang7Dongwei Dai8Rui Zhao9Qiang Li10Qinghai Huang11Yi Xu12Pengfei Yang13Jianmin Liu14Qiao Zuo15Neurovascular Center, Changhai Hospital, Naval Medical UniversityNeurovascular Center, Changhai Hospital, Naval Medical UniversityNeurovascular Center, Changhai Hospital, Naval Medical UniversityDepartment of Neurosurgery, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang UniversityNeurovascular Center, Changhai Hospital, Naval Medical UniversityNeurovascular Center, Changhai Hospital, Naval Medical UniversityNeurovascular Center, Changhai Hospital, Naval Medical UniversityNursing Department, Sir Run Run Shaw Hospital, Zhejiang University School of MedicineNeurovascular Center, Changhai Hospital, Naval Medical UniversityNeurovascular Center, Changhai Hospital, Naval Medical UniversityNeurovascular Center, Changhai Hospital, Naval Medical UniversityNeurovascular Center, Changhai Hospital, Naval Medical UniversityNeurovascular Center, Changhai Hospital, Naval Medical UniversityNeurovascular Center, Changhai Hospital, Naval Medical UniversityNeurovascular Center, Changhai Hospital, Naval Medical UniversityNeurovascular Center, Changhai Hospital, Naval Medical UniversityAbstract Background Stroke is the second leading cause of death worldwide, and observational studies have suggested a correlation between antioxidants and reduced stroke risk. However, it remains unclear whether causal relationships exist. Methods This study first performed a cross-sectional study of the association between the Composite Dietary Antioxidant Index (CDAI) and stroke using data from the National Health and Nutrition Examination Survey (NHANES) 2007–2018. Second, a two-sample univariable Mendelian Randomization (MR) was performed to analyze the causal effect of circulating levels of antioxidants on different subtypes of stroke. Results The cross-sectional study included a total of 24,892 participants representing more than 200 million US non-institutionalized residents, a multivariable logistic regression model revealed that the risk of stroke decreased by 3.4% for each unit increase in CDAI (P = 0.017), with a non-linear association found, indicating a reduction in stroke risk before an inflection point of 3.078. MR analysis revealed that genetically determined levels of retinol had a suggestive protective effect on subarachnoid hemorrhage (SAH) (OR = 0.348, P = 0.025), and genetically determined levels of selenium had a suggestive protective effect against SAH (OR = 0.826, P = 0.007). However, no causal relationship was found between antioxidants and ischemic stroke or intracranial hemorrhage risk. Conclusions Evidence suggests that diet-derived antioxidants may reduce the risk of stroke, as indicated by the protective effects of retinol and selenium against SAH. However, more research is needed to fully understand how antioxidants prevent stroke.https://doi.org/10.1186/s40001-024-01646-5AntioxidantsRetinolSeleniumStrokeSubarachnoid hemorrhageNHANES |
spellingShingle | Rundong Chen Hanchen Liu Guanghao Zhang Qian Zhang Weilong Hua Lei Zhang Nan Lv Yilei Zhang Dongwei Dai Rui Zhao Qiang Li Qinghai Huang Yi Xu Pengfei Yang Jianmin Liu Qiao Zuo Antioxidants and the risk of stroke: results from NHANES and two-sample Mendelian randomization study European Journal of Medical Research Antioxidants Retinol Selenium Stroke Subarachnoid hemorrhage NHANES |
title | Antioxidants and the risk of stroke: results from NHANES and two-sample Mendelian randomization study |
title_full | Antioxidants and the risk of stroke: results from NHANES and two-sample Mendelian randomization study |
title_fullStr | Antioxidants and the risk of stroke: results from NHANES and two-sample Mendelian randomization study |
title_full_unstemmed | Antioxidants and the risk of stroke: results from NHANES and two-sample Mendelian randomization study |
title_short | Antioxidants and the risk of stroke: results from NHANES and two-sample Mendelian randomization study |
title_sort | antioxidants and the risk of stroke results from nhanes and two sample mendelian randomization study |
topic | Antioxidants Retinol Selenium Stroke Subarachnoid hemorrhage NHANES |
url | https://doi.org/10.1186/s40001-024-01646-5 |
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