Metabolism and Pharmacokinetics of SP-8356, a Novel (1<i>S</i>)-(−)-Verbenone Derivative, in Rats and Dogs and Its Implications in Humans

Metabolism and Pharmacokinetics of SP-8356, a Novel (1<i>S</i>)-(−)-Verbenone Derivative, in Rats and Dogs and Its Implications in Humans

(1<i>S</i>,5<i>R</i>)-4-((<i>E</i>)-3,4-dihydroxy-5-methoxystryryl)-6,6-dimethylbicylco[3.1.1]hept-3-en-2-one (SP-8356) is a novel (1<i>S</i>)-(−)-verbenone derivative that is currently in preclinical development for the treatment of ischemic stroke an...

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Bibliographic Details
Main Authors: Yuanyuan Zhou, Mun Hwan Oh, Yeon Joon Kim, Eun-yeong Kim, Jinhong Kang, Sung Chung, Chung Ju, Won-Ki Kim, Kiho Lee
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:Molecules
Subjects:
SP-8356
pharmacokinetics
metabolism
bioactivation
conjugation
Online Access:https://www.mdpi.com/1420-3049/25/8/1775

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