Resemblance of the Recurrence Patterns in Primary Systemic, Primary Surgery and Secondary Oncoplastic Surgery
Purpose: Surgical interventions tend to have an effect on the generation of recurrences in tumor patients due to the anesthesia involved as well as tissue damage and subsequent inflammation. This can also be found in patients with breast cancer. Methods: In this multicenter study, we investigated da...
| Main Authors: | , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-11-01
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| Series: | Current Oncology |
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| Online Access: | https://www.mdpi.com/1718-7729/29/11/698 |
| _version_ | 1827644708541693952 |
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| author | Davut Dayan Kristina Ernst Bahriye Aktas Raffaela Baierl Susanne Briest Martin Dengler Daniela Dieterle Amelie Endres Kathrin Engelken Andree Faridi Hannes Frenz Peer Hantschmann Wolfgang Janni Christina Kaiser Thorsten Kokott Stefanie Laufhütte Florian Schober Florian Ebner |
| author_facet | Davut Dayan Kristina Ernst Bahriye Aktas Raffaela Baierl Susanne Briest Martin Dengler Daniela Dieterle Amelie Endres Kathrin Engelken Andree Faridi Hannes Frenz Peer Hantschmann Wolfgang Janni Christina Kaiser Thorsten Kokott Stefanie Laufhütte Florian Schober Florian Ebner |
| author_sort | Davut Dayan |
| collection | DOAJ |
| description | Purpose: Surgical interventions tend to have an effect on the generation of recurrences in tumor patients due to the anesthesia involved as well as tissue damage and subsequent inflammation. This can also be found in patients with breast cancer. Methods: In this multicenter study, we investigated data of 632 patients with breast cancer and the subsequent diagnosis of a recurrence. The patient data were acquired from 1 January 2006 to 31 December 2019 in eight different centers in Germany. The data sets were separated into those with primary surgery, primary systemic therapy with subsequent surgery, and reconstructive surgery. Three different starting points for observation were defined: the date of diagnosis, the date of first surgery, and the date of reconstructive surgery, if applicable. The observational period was divided into steps of six months and maxima of recurrences were compared. Furthermore, the variance was calculated using the difference of the distribution in percent. Results: The descriptive analysis showed no resemblance between the groups. The variance of the difference of the recurrence rates analysis using the surgical date as the starting point showed similarities in the age subgroup. Conclusion: Our clinical analysis shows different metastatic behavior in different analysis and treatment regimes. These findings justify further investigations on a larger database. These results may possibly identify an improved follow-up setting depending on tumor stage, biology, treatment, and patient factors (i.e., age, …). |
| first_indexed | 2024-03-09T18:24:15Z |
| format | Article |
| id | doaj.art-2f6baa75214947b087c2d2f2b11beabf |
| institution | Directory Open Access Journal |
| issn | 1198-0052 1718-7729 |
| language | English |
| last_indexed | 2024-03-09T18:24:15Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Current Oncology |
| spelling | doaj.art-2f6baa75214947b087c2d2f2b11beabf2023-11-24T08:03:25ZengMDPI AGCurrent Oncology1198-00521718-77292022-11-0129118874888510.3390/curroncol29110698Resemblance of the Recurrence Patterns in Primary Systemic, Primary Surgery and Secondary Oncoplastic SurgeryDavut Dayan0Kristina Ernst1Bahriye Aktas2Raffaela Baierl3Susanne Briest4Martin Dengler5Daniela Dieterle6Amelie Endres7Kathrin Engelken8Andree Faridi9Hannes Frenz10Peer Hantschmann11Wolfgang Janni12Christina Kaiser13Thorsten Kokott14Stefanie Laufhütte15Florian Schober16Florian Ebner17Frauenklinik, Universität Ulm, 89075 Ulm, GermanyFrauenklinik, Universität Ulm, 89075 Ulm, GermanyUniversitätsklinik Leipzig, Frauenklinik, 04103 Leipzig, GermanyBrustkrebszentrum Passau, Klinikum Passau, 94032 Passau, GermanyUniversitätsklinik Leipzig, Frauenklinik, 04103 Leipzig, GermanyBrustkrebszentrum Passau, Klinikum Passau, 94032 Passau, GermanyBrustzentrum Kaufbeuren, Klinikum Kaufbeuren, 87600 Kaufbeuren, GermanyUniversität Tübingen, 72016 Tübingen, GermanyBrustzentrum Stade, 21682 Stade, GermanyBrustzentrum, Universität Bonn, 53127 Bonn, GermanyUniversität Tübingen, 72016 Tübingen, GermanyKlinikum Altötting, Frauenklinik, 84503 Altötting, GermanyFrauenklinik, Universität Ulm, 89075 Ulm, GermanyBrustzentrum, Universität Bonn, 53127 Bonn, GermanyBrustzentrum Stade, 21682 Stade, GermanyKlinikum Altötting, Frauenklinik, 84503 Altötting, GermanyPlastische Chirurgie, Diakoneo Schwäbisch Hall, 74523 Schwäbisch Hall, GermanyFrauenarztpraxis Freising, Marienplatz, 585354 Freising, GermanyPurpose: Surgical interventions tend to have an effect on the generation of recurrences in tumor patients due to the anesthesia involved as well as tissue damage and subsequent inflammation. This can also be found in patients with breast cancer. Methods: In this multicenter study, we investigated data of 632 patients with breast cancer and the subsequent diagnosis of a recurrence. The patient data were acquired from 1 January 2006 to 31 December 2019 in eight different centers in Germany. The data sets were separated into those with primary surgery, primary systemic therapy with subsequent surgery, and reconstructive surgery. Three different starting points for observation were defined: the date of diagnosis, the date of first surgery, and the date of reconstructive surgery, if applicable. The observational period was divided into steps of six months and maxima of recurrences were compared. Furthermore, the variance was calculated using the difference of the distribution in percent. Results: The descriptive analysis showed no resemblance between the groups. The variance of the difference of the recurrence rates analysis using the surgical date as the starting point showed similarities in the age subgroup. Conclusion: Our clinical analysis shows different metastatic behavior in different analysis and treatment regimes. These findings justify further investigations on a larger database. These results may possibly identify an improved follow-up setting depending on tumor stage, biology, treatment, and patient factors (i.e., age, …).https://www.mdpi.com/1718-7729/29/11/698breastcancerrecurrencepatternoncoplastic |
| spellingShingle | Davut Dayan Kristina Ernst Bahriye Aktas Raffaela Baierl Susanne Briest Martin Dengler Daniela Dieterle Amelie Endres Kathrin Engelken Andree Faridi Hannes Frenz Peer Hantschmann Wolfgang Janni Christina Kaiser Thorsten Kokott Stefanie Laufhütte Florian Schober Florian Ebner Resemblance of the Recurrence Patterns in Primary Systemic, Primary Surgery and Secondary Oncoplastic Surgery Current Oncology breast cancer recurrence pattern oncoplastic |
| title | Resemblance of the Recurrence Patterns in Primary Systemic, Primary Surgery and Secondary Oncoplastic Surgery |
| title_full | Resemblance of the Recurrence Patterns in Primary Systemic, Primary Surgery and Secondary Oncoplastic Surgery |
| title_fullStr | Resemblance of the Recurrence Patterns in Primary Systemic, Primary Surgery and Secondary Oncoplastic Surgery |
| title_full_unstemmed | Resemblance of the Recurrence Patterns in Primary Systemic, Primary Surgery and Secondary Oncoplastic Surgery |
| title_short | Resemblance of the Recurrence Patterns in Primary Systemic, Primary Surgery and Secondary Oncoplastic Surgery |
| title_sort | resemblance of the recurrence patterns in primary systemic primary surgery and secondary oncoplastic surgery |
| topic | breast cancer recurrence pattern oncoplastic |
| url | https://www.mdpi.com/1718-7729/29/11/698 |
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