Kinetics of HIV-1 capsid uncoating revealed by single-molecule analysis

Kinetics of HIV-1 capsid uncoating revealed by single-molecule analysis

Uncoating of the metastable HIV-1 capsid is a tightly regulated disassembly process required for release of the viral cDNA prior to nuclear import. To understand the intrinsic capsid disassembly pathway and how it can be modulated, we have developed a single-particle fluorescence microscopy method t...

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Bibliographic Details
Main Authors: Chantal L Márquez, Derrick Lau, James Walsh, Vaibhav Shah, Conall McGuinness, Andrew Wong, Anupriya Aggarwal, Michael W Parker, David A Jacques, Stuart Turville, Till Böcking
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-06-01
Series:eLife
Subjects:
HIV-1
capsid disassembly
fluorescence miscoscopy
single-molecule
Online Access:https://elifesciences.org/articles/34772

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