Patient and kidney graft survival rates after first and second kidney transplantation
Introduction. Expanding donation criteria is one way of solving the problem of the increasing need of transplantation. The article is dedicated to comparison of the outcomes of first and second repeated kidney transplantation using grafts from standard criteria and expanded criteria donors.Aim. To e...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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N.V. Sklifosovsky Research Institute for Emergency Medicine of Moscow Healthcare Department
2021-06-01
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| Series: | Трансплантология (Москва) |
| Subjects: | |
| Online Access: | https://www.jtransplantologiya.ru/jour/article/view/570 |
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| author | M. Sh. Khubutiya A. V. Pinchuk N. V. Shmarina I. V. Dmitriev V. E. Vinogradov A. I. Kazantsev A. G. Balkarov |
| author_facet | M. Sh. Khubutiya A. V. Pinchuk N. V. Shmarina I. V. Dmitriev V. E. Vinogradov A. I. Kazantsev A. G. Balkarov |
| author_sort | M. Sh. Khubutiya |
| collection | DOAJ |
| description | Introduction. Expanding donation criteria is one way of solving the problem of the increasing need of transplantation. The article is dedicated to comparison of the outcomes of first and second repeated kidney transplantation using grafts from standard criteria and expanded criteria donors.Aim. To evaluate 1-year and 5-year recipient and kidney graft survival rates after first and second kidney transplantation according to the donor type – standard criteria or expanded criteria donors.Material and methods. From 2007 till 2019 we performed 1459 kidney transplantations. The comparison study of outcomes of first (n=196) and second (n=143) kidney transplantations from standard criteria (n=245) and expanded criteria (n=94) donors was made.Results. There were no significant differences in a 1-year patient survival according to the donor type (98% and 95%, p=0.13). A 5-year recipient survival was significantly poorer after kidney transplantation from expanded criteria donors (97.6% and 88%, p=0.01). There were no significant differences in 1-year and 5-year graft survival rates according to the order of transplantation (p=0.21 and p=0.36). We found no significant difference in 1-year recipient survival after kidney transplantation from expanded criteria donors according to the order of transplantation (p=0.50). A 5-year recipient survival was significantly difference poorer after second kidney transplantation from expanded criteria donors (p=0.04). One-year and 5-year graft survival rates were significantly lower after kidney transplantation from expanded criteria donors (94%, 88% vs 86%, 65%, p=0.0025 and p=0.0011, respectively). One-year and 5-year survival rates were higher after first kidney transplantation from standard criteria donors in comparison with second kidney transplantation (p=0.052 and p=0.02, statistically significant in both cases). Analyzing outcomes of kidney transplantation from expanded criteria donors we found 1-year and 5-year graft survivals to be higher after first kidney transplantation comparing with second kidney transplantation (p=0.030 and p=0.018, statistically significant in both cases).Conclusion. In case of second organ transplantation, it is reasonable to use organs from standard criteria donors. |
| first_indexed | 2024-03-12T04:17:46Z |
| format | Article |
| id | doaj.art-2f6e348b92ef4136953311cf5601e7ef |
| institution | Directory Open Access Journal |
| issn | 2074-0506 2542-0909 |
| language | English |
| last_indexed | 2024-03-12T04:17:46Z |
| publishDate | 2021-06-01 |
| publisher | N.V. Sklifosovsky Research Institute for Emergency Medicine of Moscow Healthcare Department |
| record_format | Article |
| series | Трансплантология (Москва) |
| spelling | doaj.art-2f6e348b92ef4136953311cf5601e7ef2023-09-03T10:34:46ZengN.V. Sklifosovsky Research Institute for Emergency Medicine of Moscow Healthcare DepartmentТрансплантология (Москва)2074-05062542-09092021-06-0113213014010.23873/2074-0506-2021-13-2-130-140478Patient and kidney graft survival rates after first and second kidney transplantationM. Sh. Khubutiya0A. V. Pinchuk1N. V. Shmarina2I. V. Dmitriev3V. E. Vinogradov4A. I. Kazantsev5A. G. Balkarov6ГБУЗ «НИИ скорой помощи им. Н.В. Склифосовского ДЗМ»; ФГБОУ ВО МГМСУ им. А.И. Евдокимова МЗ РФГБУЗ «НИИ скорой помощи им. Н.В. Склифосовского ДЗМ»; ФГБОУ ВО МГМСУ им. А.И. Евдокимова МЗ РФ; ГБУ «НИИ организации здравоохранения и медицинского менеджмента ДЗМ»ГБУЗ «НИИ скорой помощи им. Н.В. Склифосовского ДЗМ»ГБУЗ «НИИ скорой помощи им. Н.В. Склифосовского ДЗМ»ГБУ «НИИ организации здравоохранения и медицинского менеджмента ДЗМ»; Московский городской научно-практический центр нефрологии и патологии трансплантированной почки ГБУЗ «ГКБ № 52 ДЗМ»ГБУЗ «НИИ скорой помощи им. Н.В. Склифосовского ДЗМ»ГБУЗ «НИИ скорой помощи им. Н.В. Склифосовского ДЗМ»; ГБУ «НИИ организации здравоохранения и медицинского менеджмента ДЗМ»Introduction. Expanding donation criteria is one way of solving the problem of the increasing need of transplantation. The article is dedicated to comparison of the outcomes of first and second repeated kidney transplantation using grafts from standard criteria and expanded criteria donors.Aim. To evaluate 1-year and 5-year recipient and kidney graft survival rates after first and second kidney transplantation according to the donor type – standard criteria or expanded criteria donors.Material and methods. From 2007 till 2019 we performed 1459 kidney transplantations. The comparison study of outcomes of first (n=196) and second (n=143) kidney transplantations from standard criteria (n=245) and expanded criteria (n=94) donors was made.Results. There were no significant differences in a 1-year patient survival according to the donor type (98% and 95%, p=0.13). A 5-year recipient survival was significantly poorer after kidney transplantation from expanded criteria donors (97.6% and 88%, p=0.01). There were no significant differences in 1-year and 5-year graft survival rates according to the order of transplantation (p=0.21 and p=0.36). We found no significant difference in 1-year recipient survival after kidney transplantation from expanded criteria donors according to the order of transplantation (p=0.50). A 5-year recipient survival was significantly difference poorer after second kidney transplantation from expanded criteria donors (p=0.04). One-year and 5-year graft survival rates were significantly lower after kidney transplantation from expanded criteria donors (94%, 88% vs 86%, 65%, p=0.0025 and p=0.0011, respectively). One-year and 5-year survival rates were higher after first kidney transplantation from standard criteria donors in comparison with second kidney transplantation (p=0.052 and p=0.02, statistically significant in both cases). Analyzing outcomes of kidney transplantation from expanded criteria donors we found 1-year and 5-year graft survivals to be higher after first kidney transplantation comparing with second kidney transplantation (p=0.030 and p=0.018, statistically significant in both cases).Conclusion. In case of second organ transplantation, it is reasonable to use organs from standard criteria donors.https://www.jtransplantologiya.ru/jour/article/view/570первая трансплантация почкиповторная (вторая) трансплантация почкиисходывыживаемость реципиентоввыживаемость почечного трансплантата |
| spellingShingle | M. Sh. Khubutiya A. V. Pinchuk N. V. Shmarina I. V. Dmitriev V. E. Vinogradov A. I. Kazantsev A. G. Balkarov Patient and kidney graft survival rates after first and second kidney transplantation Трансплантология (Москва) первая трансплантация почки повторная (вторая) трансплантация почки исходы выживаемость реципиентов выживаемость почечного трансплантата |
| title | Patient and kidney graft survival rates after first and second kidney transplantation |
| title_full | Patient and kidney graft survival rates after first and second kidney transplantation |
| title_fullStr | Patient and kidney graft survival rates after first and second kidney transplantation |
| title_full_unstemmed | Patient and kidney graft survival rates after first and second kidney transplantation |
| title_short | Patient and kidney graft survival rates after first and second kidney transplantation |
| title_sort | patient and kidney graft survival rates after first and second kidney transplantation |
| topic | первая трансплантация почки повторная (вторая) трансплантация почки исходы выживаемость реципиентов выживаемость почечного трансплантата |
| url | https://www.jtransplantologiya.ru/jour/article/view/570 |
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