New immunological aspects of peri-implantitis
ABSTRACT Objective: This study aimed to compare the levels of HIF1-α, VEGF, TNF-α, and IL-10 in the peri-implant crevicular fluid of patients with and without peri-implantitis. Methods: Forty patients, comprising 16 with and 24 without peri-implantitis were selected. Results: Patients with peri-i...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Instituto Israelita de Ensino e Pesquisa Albert Einstein
2024-03-01
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| Series: | Einstein (São Paulo) |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1679-45082024000100202&tlng=en |
| _version_ | 1797265381720588288 |
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| author | Bárbara Bellocchio Bertoldo Guilherme Oliveira Paulo Taíssa Cássia de Souza Furtado Thiago Lima Pereira Virmondes Rodrigues Junior Denise Bertulucci Rocha Rodrigues Juliana Barbosa de Faria Rodrigo César Rosa Sanívia Aparecida de Lima Pereira |
| author_facet | Bárbara Bellocchio Bertoldo Guilherme Oliveira Paulo Taíssa Cássia de Souza Furtado Thiago Lima Pereira Virmondes Rodrigues Junior Denise Bertulucci Rocha Rodrigues Juliana Barbosa de Faria Rodrigo César Rosa Sanívia Aparecida de Lima Pereira |
| author_sort | Bárbara Bellocchio Bertoldo |
| collection | DOAJ |
| description | ABSTRACT Objective: This study aimed to compare the levels of HIF1-α, VEGF, TNF-α, and IL-10 in the peri-implant crevicular fluid of patients with and without peri-implantitis. Methods: Forty patients, comprising 16 with and 24 without peri-implantitis were selected. Results: Patients with peri-implantitis exhibited significantly higher HIF-1α levels than those without peri-implantitis (p=0.0005). TNF-α revealed significant positive correlations with IL-10 (p=0.0008) and VEGF (p=0.0246), whereas HIF-1α and IL-10 levels (p=0.0041) demonstrated a negative and significative correlation in the peri-implantitis group. Conclusion: This study, for the first time demonstrates the balance of HIF-1α, TNFα, IL-10, and VEGF in peri-implantitis. It shows an elevated HIF-1α levels in patients with peri-implantitis, which could have stemmed from persistent inflammation- triggered hypoxia. Furthermore, the positive correlation between TNF-α and VEGF suggests intensified proinflammatory activity in peri-implantitis. Nevertheless, further studies are essential to understand these immune dynamics in peri-implantitis. |
| first_indexed | 2024-04-25T00:43:54Z |
| format | Article |
| id | doaj.art-2f6e86a83ae5403abaae7d3f0ad41990 |
| institution | Directory Open Access Journal |
| issn | 2317-6385 |
| language | English |
| last_indexed | 2024-04-25T00:43:54Z |
| publishDate | 2024-03-01 |
| publisher | Instituto Israelita de Ensino e Pesquisa Albert Einstein |
| record_format | Article |
| series | Einstein (São Paulo) |
| spelling | doaj.art-2f6e86a83ae5403abaae7d3f0ad419902024-03-12T07:38:53ZengInstituto Israelita de Ensino e Pesquisa Albert EinsteinEinstein (São Paulo)2317-63852024-03-012210.31744/einstein_journal/2024ao0396New immunological aspects of peri-implantitisBárbara Bellocchio Bertoldohttps://orcid.org/0000-0003-0628-9792Guilherme Oliveira Paulohttps://orcid.org/0000-0003-2026-6079Taíssa Cássia de Souza Furtadohttps://orcid.org/0000-0002-8186-1798Thiago Lima Pereirahttps://orcid.org/0000-0002-6601-0207Virmondes Rodrigues Juniorhttps://orcid.org/0000-0001-8706-4223Denise Bertulucci Rocha Rodrigueshttps://orcid.org/0000-0003-0447-6244Juliana Barbosa de Fariahttps://orcid.org/0000-0002-9681-2278Rodrigo César Rosahttps://orcid.org/0000-0003-3157-0826Sanívia Aparecida de Lima Pereirahttps://orcid.org/0000-0002-0293-2587ABSTRACT Objective: This study aimed to compare the levels of HIF1-α, VEGF, TNF-α, and IL-10 in the peri-implant crevicular fluid of patients with and without peri-implantitis. Methods: Forty patients, comprising 16 with and 24 without peri-implantitis were selected. Results: Patients with peri-implantitis exhibited significantly higher HIF-1α levels than those without peri-implantitis (p=0.0005). TNF-α revealed significant positive correlations with IL-10 (p=0.0008) and VEGF (p=0.0246), whereas HIF-1α and IL-10 levels (p=0.0041) demonstrated a negative and significative correlation in the peri-implantitis group. Conclusion: This study, for the first time demonstrates the balance of HIF-1α, TNFα, IL-10, and VEGF in peri-implantitis. It shows an elevated HIF-1α levels in patients with peri-implantitis, which could have stemmed from persistent inflammation- triggered hypoxia. Furthermore, the positive correlation between TNF-α and VEGF suggests intensified proinflammatory activity in peri-implantitis. Nevertheless, further studies are essential to understand these immune dynamics in peri-implantitis.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1679-45082024000100202&tlng=enHypoxia-inducible factor 1Interleukin-10Peri-implantitisTumor necrosis factor-alphaVascular endothelial growth factors |
| spellingShingle | Bárbara Bellocchio Bertoldo Guilherme Oliveira Paulo Taíssa Cássia de Souza Furtado Thiago Lima Pereira Virmondes Rodrigues Junior Denise Bertulucci Rocha Rodrigues Juliana Barbosa de Faria Rodrigo César Rosa Sanívia Aparecida de Lima Pereira New immunological aspects of peri-implantitis Einstein (São Paulo) Hypoxia-inducible factor 1 Interleukin-10 Peri-implantitis Tumor necrosis factor-alpha Vascular endothelial growth factors |
| title | New immunological aspects of peri-implantitis |
| title_full | New immunological aspects of peri-implantitis |
| title_fullStr | New immunological aspects of peri-implantitis |
| title_full_unstemmed | New immunological aspects of peri-implantitis |
| title_short | New immunological aspects of peri-implantitis |
| title_sort | new immunological aspects of peri implantitis |
| topic | Hypoxia-inducible factor 1 Interleukin-10 Peri-implantitis Tumor necrosis factor-alpha Vascular endothelial growth factors |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1679-45082024000100202&tlng=en |
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