Pneumothorax during Pemetrexed Treatment in a Patient with Non-Small Cell Lung Cancer: A Case Report and Literature Review
Pemetrexed is a multitargeted antifolate that has demonstrated antitumor activity in non-small cell lung cancer. A 70-year-old male presented with a stage IV non-small cell lung cancer. The patient was treated with pemetrexed as third-line chemotherapy. However, a pneumothorax occurred 16 days after...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Karger Publishers
2017-05-01
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| Series: | Case Reports in Oncology |
| Subjects: | |
| Online Access: | http://www.karger.com/Article/FullText/471479 |
| _version_ | 1819206740135116800 |
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| author | Yoshiro Nakahara Shinichiro Mikura Makoto Nagamata Tomoya Fukui Jiichiro Sasaki Noriyuki Masuda |
| author_facet | Yoshiro Nakahara Shinichiro Mikura Makoto Nagamata Tomoya Fukui Jiichiro Sasaki Noriyuki Masuda |
| author_sort | Yoshiro Nakahara |
| collection | DOAJ |
| description | Pemetrexed is a multitargeted antifolate that has demonstrated antitumor activity in non-small cell lung cancer. A 70-year-old male presented with a stage IV non-small cell lung cancer. The patient was treated with pemetrexed as third-line chemotherapy. However, a pneumothorax occurred 16 days after the administration of the second cycle of pemetrexed. The pneumothorax was slight and the patient was observed without undergoing any additional treatment. Twenty-four days after its initial occurrence, the pneumothorax had improved. This is the first case of pneumothorax that has been observed during pemetrexed treatment. Pneumothorax during chemotherapy is rare; however, it is a life-threatening complication and should not be overlooked. |
| first_indexed | 2024-12-23T05:12:24Z |
| format | Article |
| id | doaj.art-2f70609f23d14b308ad6860e19393bfe |
| institution | Directory Open Access Journal |
| issn | 1662-6575 |
| language | English |
| last_indexed | 2024-12-23T05:12:24Z |
| publishDate | 2017-05-01 |
| publisher | Karger Publishers |
| record_format | Article |
| series | Case Reports in Oncology |
| spelling | doaj.art-2f70609f23d14b308ad6860e19393bfe2022-12-21T17:58:56ZengKarger PublishersCase Reports in Oncology1662-65752017-05-0110242843210.1159/000471479471479Pneumothorax during Pemetrexed Treatment in a Patient with Non-Small Cell Lung Cancer: A Case Report and Literature ReviewYoshiro NakaharaShinichiro MikuraMakoto NagamataTomoya FukuiJiichiro SasakiNoriyuki MasudaPemetrexed is a multitargeted antifolate that has demonstrated antitumor activity in non-small cell lung cancer. A 70-year-old male presented with a stage IV non-small cell lung cancer. The patient was treated with pemetrexed as third-line chemotherapy. However, a pneumothorax occurred 16 days after the administration of the second cycle of pemetrexed. The pneumothorax was slight and the patient was observed without undergoing any additional treatment. Twenty-four days after its initial occurrence, the pneumothorax had improved. This is the first case of pneumothorax that has been observed during pemetrexed treatment. Pneumothorax during chemotherapy is rare; however, it is a life-threatening complication and should not be overlooked.http://www.karger.com/Article/FullText/471479PemetrexedPneumothoraxNon-small cell lung cancer |
| spellingShingle | Yoshiro Nakahara Shinichiro Mikura Makoto Nagamata Tomoya Fukui Jiichiro Sasaki Noriyuki Masuda Pneumothorax during Pemetrexed Treatment in a Patient with Non-Small Cell Lung Cancer: A Case Report and Literature Review Case Reports in Oncology Pemetrexed Pneumothorax Non-small cell lung cancer |
| title | Pneumothorax during Pemetrexed Treatment in a Patient with Non-Small Cell Lung Cancer: A Case Report and Literature Review |
| title_full | Pneumothorax during Pemetrexed Treatment in a Patient with Non-Small Cell Lung Cancer: A Case Report and Literature Review |
| title_fullStr | Pneumothorax during Pemetrexed Treatment in a Patient with Non-Small Cell Lung Cancer: A Case Report and Literature Review |
| title_full_unstemmed | Pneumothorax during Pemetrexed Treatment in a Patient with Non-Small Cell Lung Cancer: A Case Report and Literature Review |
| title_short | Pneumothorax during Pemetrexed Treatment in a Patient with Non-Small Cell Lung Cancer: A Case Report and Literature Review |
| title_sort | pneumothorax during pemetrexed treatment in a patient with non small cell lung cancer a case report and literature review |
| topic | Pemetrexed Pneumothorax Non-small cell lung cancer |
| url | http://www.karger.com/Article/FullText/471479 |
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