RNP-world: The ultimate essence of life is a ribonucleoprotein process
Abstract The fundamental essence of life is based on process of interaction between nucleic acids and proteins. In a prebiotic world, amino acids, peptides, ions, and other metabolites acted in protobiotic routes at the same time on which RNAs performed catalysis and self-replication. Nevertheless,...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Sociedade Brasileira de Genética
2022-09-01
|
| Series: | Genetics and Molecular Biology |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572022000400106&tlng=en |
| _version_ | 1811204023418617856 |
|---|---|
| author | Sávio Torres de Farias Francisco Prosdocimi |
| author_facet | Sávio Torres de Farias Francisco Prosdocimi |
| author_sort | Sávio Torres de Farias |
| collection | DOAJ |
| description | Abstract The fundamental essence of life is based on process of interaction between nucleic acids and proteins. In a prebiotic world, amino acids, peptides, ions, and other metabolites acted in protobiotic routes at the same time on which RNAs performed catalysis and self-replication. Nevertheless, it was only when nucleic acids and peptides started to interact together in an organized process that life emerged. First, the ignition was sparked with the formation of a Peptidyl Transferase Center (PTC), possibly by concatenation of proto-tRNAs. This molecule that would become the catalytic site of ribosomes started a process of self-organization that gave origin to a protoorganism named FUCA, a ribonucleic ribosomal-like apparatus capable to polymerize amino acids. In that sense, we review hypotheses about the origin and early evolution of the genetic code. Next, populations of open biological systems named progenotes were capable of accumulating and exchanging genetic material, producing the first genomes. Progenotes then evolved in two paths: some presented their own ribosomes and others used available ribosomes in the medium to translate their encoded information. At some point, two different types of organisms emerged from populations of progenotes: the ribosome-encoding organisms (cells) and the capsid-encoding organisms (viruses). |
| first_indexed | 2024-04-12T03:05:57Z |
| format | Article |
| id | doaj.art-2f721b63a70e48f1977a6625c693df52 |
| institution | Directory Open Access Journal |
| issn | 1678-4685 |
| language | English |
| last_indexed | 2024-04-12T03:05:57Z |
| publishDate | 2022-09-01 |
| publisher | Sociedade Brasileira de Genética |
| record_format | Article |
| series | Genetics and Molecular Biology |
| spelling | doaj.art-2f721b63a70e48f1977a6625c693df522022-12-22T03:50:31ZengSociedade Brasileira de GenéticaGenetics and Molecular Biology1678-46852022-09-01453 suppl 110.1590/1678-4685-gmb-2022-0127RNP-world: The ultimate essence of life is a ribonucleoprotein processSávio Torres de Fariashttps://orcid.org/0000-0002-2997-3629Francisco Prosdocimihttps://orcid.org/0000-0002-6761-3069Abstract The fundamental essence of life is based on process of interaction between nucleic acids and proteins. In a prebiotic world, amino acids, peptides, ions, and other metabolites acted in protobiotic routes at the same time on which RNAs performed catalysis and self-replication. Nevertheless, it was only when nucleic acids and peptides started to interact together in an organized process that life emerged. First, the ignition was sparked with the formation of a Peptidyl Transferase Center (PTC), possibly by concatenation of proto-tRNAs. This molecule that would become the catalytic site of ribosomes started a process of self-organization that gave origin to a protoorganism named FUCA, a ribonucleic ribosomal-like apparatus capable to polymerize amino acids. In that sense, we review hypotheses about the origin and early evolution of the genetic code. Next, populations of open biological systems named progenotes were capable of accumulating and exchanging genetic material, producing the first genomes. Progenotes then evolved in two paths: some presented their own ribosomes and others used available ribosomes in the medium to translate their encoded information. At some point, two different types of organisms emerged from populations of progenotes: the ribosome-encoding organisms (cells) and the capsid-encoding organisms (viruses).http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572022000400106&tlng=enRibosometRNAsorigin of lifegene originFUCA |
| spellingShingle | Sávio Torres de Farias Francisco Prosdocimi RNP-world: The ultimate essence of life is a ribonucleoprotein process Genetics and Molecular Biology Ribosome tRNAs origin of life gene origin FUCA |
| title | RNP-world: The ultimate essence of life is a ribonucleoprotein process |
| title_full | RNP-world: The ultimate essence of life is a ribonucleoprotein process |
| title_fullStr | RNP-world: The ultimate essence of life is a ribonucleoprotein process |
| title_full_unstemmed | RNP-world: The ultimate essence of life is a ribonucleoprotein process |
| title_short | RNP-world: The ultimate essence of life is a ribonucleoprotein process |
| title_sort | rnp world the ultimate essence of life is a ribonucleoprotein process |
| topic | Ribosome tRNAs origin of life gene origin FUCA |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572022000400106&tlng=en |
| work_keys_str_mv | AT saviotorresdefarias rnpworldtheultimateessenceoflifeisaribonucleoproteinprocess AT franciscoprosdocimi rnpworldtheultimateessenceoflifeisaribonucleoproteinprocess |