A probiotic bi-functional peptidoglycan hydrolase sheds NOD2 ligands to regulate gut homeostasis in female mice
Abstract Secreted proteins are one of the direct molecular mechanisms by which microbiota influence the host, thus constituting a promising field for drug discovery. Here, through bioinformatics-guided screening of the secretome of clinically established probiotics from Lactobacillus, we identify an...
Main Authors: | Jie Gao, Lei Wang, Jing Jiang, Qian Xu, Nianyi Zeng, Bingyun Lu, Peibo Yuan, Kai Sun, Hongwei Zhou, Xiaolong He |
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Format: | Article |
Language: | English |
Published: |
Nature Portfolio
2023-06-01
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Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-023-38950-3 |
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