Influence of Personality, Resilience and Life Conditions on Depression and Anxiety in 104 Patients Having Survived Acute Autoimmune Thrombotic Thrombocytopenic Purpura
Autoimmune thrombotic thrombocytopenic purpura (iTTP) is a life-threatening, relapsing disease in which an acquired deficiency of the enzyme ADAMTS13 leads to generalised microvascular thrombosis. Survivors have a high prevalence of depression and impaired cognitive function. The aim of this study w...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-01-01
|
| Series: | Journal of Clinical Medicine |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2077-0383/10/2/365 |
| _version_ | 1797409731320479744 |
|---|---|
| author | Tanja Falter Sibylle Böschen Markus Schepers Manfred Beutel Karl Lackner Inge Scharrer Bernhard Lämmle |
| author_facet | Tanja Falter Sibylle Böschen Markus Schepers Manfred Beutel Karl Lackner Inge Scharrer Bernhard Lämmle |
| author_sort | Tanja Falter |
| collection | DOAJ |
| description | Autoimmune thrombotic thrombocytopenic purpura (iTTP) is a life-threatening, relapsing disease in which an acquired deficiency of the enzyme ADAMTS13 leads to generalised microvascular thrombosis. Survivors have a high prevalence of depression and impaired cognitive function. The aim of this study was to determine whether life circumstances and personality have an influence on the development and severity of depression and anxiety in iTTP patients and how they impact the quality of life. With validated questionnaires, we examined the prevalence of depression and anxiety symptoms in 104 iTTP patients, as well as parameters of subjective cognitive deficits, quality of life, attitude to life and resilience. iTTP patients had significantly more depressive symptoms (<i>p</i> < 0.001), a tendency to have anxiety disorders (<i>p</i> = 0.035) and a significantly worse cognitive performance (<i>p</i> = 0.008) compared to the controls. Sex, age, physical activity and partnership status had no significant influence on depression, whereas the number of comorbidities did. Lower scores of resilience, attitude to life and quality of life were reported by patients compared to controls. iTTP patients had a high prevalence of depression and anxiety, as well as a more negative attitude to life and low resilience. Resilience correlated negatively with the severity of the depression. Furthermore, quality of life and cognitive performance were significantly reduced. |
| first_indexed | 2024-03-09T04:18:45Z |
| format | Article |
| id | doaj.art-2f73f7a3ad1c4f89b911bbfb8745941f |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-09T04:18:45Z |
| publishDate | 2021-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-2f73f7a3ad1c4f89b911bbfb8745941f2023-12-03T13:49:23ZengMDPI AGJournal of Clinical Medicine2077-03832021-01-0110236510.3390/jcm10020365Influence of Personality, Resilience and Life Conditions on Depression and Anxiety in 104 Patients Having Survived Acute Autoimmune Thrombotic Thrombocytopenic PurpuraTanja Falter0Sibylle Böschen1Markus Schepers2Manfred Beutel3Karl Lackner4Inge Scharrer5Bernhard Lämmle6Institute of Clinical Chemistry and Laboratory Medicine, University Medical Center of the Johannes Gutenberg University, 55131 Mainz, GermanyInstitute of Clinical Chemistry and Laboratory Medicine, University Medical Center of the Johannes Gutenberg University, 55131 Mainz, GermanyInstitute of Medical Biostatistics, Epidemiology and Informatics (IMBEI), University Medical Center of the Johannes Gutenberg University, 55131 Mainz, GermanyDepartment of Psychosomatic Medicine and Psychotherapy, University Medical Center of the Johannes Gutenberg University, 55131 Mainz, GermanyInstitute of Clinical Chemistry and Laboratory Medicine, University Medical Center of the Johannes Gutenberg University, 55131 Mainz, GermanyCenter for Thrombosis and Hemostasis (CTH), University Medical Center of the Johannes Gutenberg University, 55131 Mainz, GermanyCenter for Thrombosis and Hemostasis (CTH), University Medical Center of the Johannes Gutenberg University, 55131 Mainz, GermanyAutoimmune thrombotic thrombocytopenic purpura (iTTP) is a life-threatening, relapsing disease in which an acquired deficiency of the enzyme ADAMTS13 leads to generalised microvascular thrombosis. Survivors have a high prevalence of depression and impaired cognitive function. The aim of this study was to determine whether life circumstances and personality have an influence on the development and severity of depression and anxiety in iTTP patients and how they impact the quality of life. With validated questionnaires, we examined the prevalence of depression and anxiety symptoms in 104 iTTP patients, as well as parameters of subjective cognitive deficits, quality of life, attitude to life and resilience. iTTP patients had significantly more depressive symptoms (<i>p</i> < 0.001), a tendency to have anxiety disorders (<i>p</i> = 0.035) and a significantly worse cognitive performance (<i>p</i> = 0.008) compared to the controls. Sex, age, physical activity and partnership status had no significant influence on depression, whereas the number of comorbidities did. Lower scores of resilience, attitude to life and quality of life were reported by patients compared to controls. iTTP patients had a high prevalence of depression and anxiety, as well as a more negative attitude to life and low resilience. Resilience correlated negatively with the severity of the depression. Furthermore, quality of life and cognitive performance were significantly reduced.https://www.mdpi.com/2077-0383/10/2/365thrombotic thrombocytopenic purpuradepressionresiliencequality of life |
| spellingShingle | Tanja Falter Sibylle Böschen Markus Schepers Manfred Beutel Karl Lackner Inge Scharrer Bernhard Lämmle Influence of Personality, Resilience and Life Conditions on Depression and Anxiety in 104 Patients Having Survived Acute Autoimmune Thrombotic Thrombocytopenic Purpura Journal of Clinical Medicine thrombotic thrombocytopenic purpura depression resilience quality of life |
| title | Influence of Personality, Resilience and Life Conditions on Depression and Anxiety in 104 Patients Having Survived Acute Autoimmune Thrombotic Thrombocytopenic Purpura |
| title_full | Influence of Personality, Resilience and Life Conditions on Depression and Anxiety in 104 Patients Having Survived Acute Autoimmune Thrombotic Thrombocytopenic Purpura |
| title_fullStr | Influence of Personality, Resilience and Life Conditions on Depression and Anxiety in 104 Patients Having Survived Acute Autoimmune Thrombotic Thrombocytopenic Purpura |
| title_full_unstemmed | Influence of Personality, Resilience and Life Conditions on Depression and Anxiety in 104 Patients Having Survived Acute Autoimmune Thrombotic Thrombocytopenic Purpura |
| title_short | Influence of Personality, Resilience and Life Conditions on Depression and Anxiety in 104 Patients Having Survived Acute Autoimmune Thrombotic Thrombocytopenic Purpura |
| title_sort | influence of personality resilience and life conditions on depression and anxiety in 104 patients having survived acute autoimmune thrombotic thrombocytopenic purpura |
| topic | thrombotic thrombocytopenic purpura depression resilience quality of life |
| url | https://www.mdpi.com/2077-0383/10/2/365 |
| work_keys_str_mv | AT tanjafalter influenceofpersonalityresilienceandlifeconditionsondepressionandanxietyin104patientshavingsurvivedacuteautoimmunethromboticthrombocytopenicpurpura AT sibylleboschen influenceofpersonalityresilienceandlifeconditionsondepressionandanxietyin104patientshavingsurvivedacuteautoimmunethromboticthrombocytopenicpurpura AT markusschepers influenceofpersonalityresilienceandlifeconditionsondepressionandanxietyin104patientshavingsurvivedacuteautoimmunethromboticthrombocytopenicpurpura AT manfredbeutel influenceofpersonalityresilienceandlifeconditionsondepressionandanxietyin104patientshavingsurvivedacuteautoimmunethromboticthrombocytopenicpurpura AT karllackner influenceofpersonalityresilienceandlifeconditionsondepressionandanxietyin104patientshavingsurvivedacuteautoimmunethromboticthrombocytopenicpurpura AT ingescharrer influenceofpersonalityresilienceandlifeconditionsondepressionandanxietyin104patientshavingsurvivedacuteautoimmunethromboticthrombocytopenicpurpura AT bernhardlammle influenceofpersonalityresilienceandlifeconditionsondepressionandanxietyin104patientshavingsurvivedacuteautoimmunethromboticthrombocytopenicpurpura |