Use of nonhuman primates in obstructive lung disease research – is it required?
In times of increasing costs for health insurances, obstructive lung diseases are a burden for both the patients and the economy. Pulmonary symptoms of asthma and chronic obstructive pulmonary disease (COPD) are similar; nevertheless, the diseases differ in pathophysiology and therapeutic approa...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Copernicus Publications
2017-06-01
|
| Series: | Primate Biology |
| Online Access: | https://www.primate-biol.net/4/131/2017/pb-4-131-2017.pdf |
| _version_ | 1818447065083019264 |
|---|---|
| author | F. Dahlmann F. Dahlmann K. Sewald |
| author_facet | F. Dahlmann F. Dahlmann K. Sewald |
| author_sort | F. Dahlmann |
| collection | DOAJ |
| description | In times of increasing costs for health insurances, obstructive lung
diseases are a burden for both the patients and the economy. Pulmonary symptoms
of asthma and chronic obstructive pulmonary disease (COPD) are similar;
nevertheless, the diseases differ in pathophysiology and therapeutic
approaches. Novel therapeutics are continuously developed, and nonhuman
primates (NHPs) provide valuable models for investigating novel biologicals
regarding efficacy and safety.<br><br>This review discusses the role of nonhuman primate models for drug
development in asthma and COPD and investigates whether alternative methods
are able to prevent animal experiments. |
| first_indexed | 2024-12-14T19:57:41Z |
| format | Article |
| id | doaj.art-2f76a8d23b274ce0a705b2db6e674700 |
| institution | Directory Open Access Journal |
| issn | 2363-4707 2363-4715 |
| language | English |
| last_indexed | 2024-12-14T19:57:41Z |
| publishDate | 2017-06-01 |
| publisher | Copernicus Publications |
| record_format | Article |
| series | Primate Biology |
| spelling | doaj.art-2f76a8d23b274ce0a705b2db6e6747002022-12-21T22:49:15ZengCopernicus PublicationsPrimate Biology2363-47072363-47152017-06-01413114210.5194/pb-4-131-2017Use of nonhuman primates in obstructive lung disease research – is it required?F. Dahlmann0F. Dahlmann1K. Sewald2German Primate Center GmbH, Infection Pathology Unit, Kellnerweg 4, 37077 Göttingen, GermanyFraunhofer Institute for Toxicology and Experimental Medicine, Preclinical Pharmacology and Immunology, Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), Member of the German Center for Lung Research (DZL), Nikolai-Fuchs-Straße 1, 30625 Hanover, GermanyFraunhofer Institute for Toxicology and Experimental Medicine, Preclinical Pharmacology and Immunology, Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), Member of the German Center for Lung Research (DZL), Nikolai-Fuchs-Straße 1, 30625 Hanover, GermanyIn times of increasing costs for health insurances, obstructive lung diseases are a burden for both the patients and the economy. Pulmonary symptoms of asthma and chronic obstructive pulmonary disease (COPD) are similar; nevertheless, the diseases differ in pathophysiology and therapeutic approaches. Novel therapeutics are continuously developed, and nonhuman primates (NHPs) provide valuable models for investigating novel biologicals regarding efficacy and safety.<br><br>This review discusses the role of nonhuman primate models for drug development in asthma and COPD and investigates whether alternative methods are able to prevent animal experiments.https://www.primate-biol.net/4/131/2017/pb-4-131-2017.pdf |
| spellingShingle | F. Dahlmann F. Dahlmann K. Sewald Use of nonhuman primates in obstructive lung disease research – is it required? Primate Biology |
| title | Use of nonhuman primates in obstructive lung disease research – is it required? |
| title_full | Use of nonhuman primates in obstructive lung disease research – is it required? |
| title_fullStr | Use of nonhuman primates in obstructive lung disease research – is it required? |
| title_full_unstemmed | Use of nonhuman primates in obstructive lung disease research – is it required? |
| title_short | Use of nonhuman primates in obstructive lung disease research – is it required? |
| title_sort | use of nonhuman primates in obstructive lung disease research is it required |
| url | https://www.primate-biol.net/4/131/2017/pb-4-131-2017.pdf |
| work_keys_str_mv | AT fdahlmann useofnonhumanprimatesinobstructivelungdiseaseresearchisitrequired AT fdahlmann useofnonhumanprimatesinobstructivelungdiseaseresearchisitrequired AT ksewald useofnonhumanprimatesinobstructivelungdiseaseresearchisitrequired |