Ketamine: a new view on therapeutic opportunities in psychiatric practice
This article is a review of evidence-based research in English for the past 15 years thanks to access via a database PubMed and Medline, about the new features out of claimed indications of the well-known short--acting anesthetic, ketamine. Latter being the antagonist of NMDA receptors by activating...
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| Format: | Article |
| Language: | English |
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Современная терапия психических расстройств
2016-09-01
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| Series: | Современная терапия психических расстройств |
| Subjects: | |
| Online Access: | http://psypharma.ru/ru/ketamin-novyy-vzglyad-na-terapevticheskie-vozmozhnosti-v-psihiatricheskoy-praktike |
| _version_ | 1818690309440143360 |
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| author | Dorovskih, I.V. Pavlova, T.A. Scheidegger, J.M. |
| author_facet | Dorovskih, I.V. Pavlova, T.A. Scheidegger, J.M. |
| author_sort | Dorovskih, I.V. |
| collection | DOAJ |
| description | This article is a review of evidence-based research in English for the past 15 years thanks to access via a database PubMed and Medline, about the new features out of claimed indications
of the well-known short--acting anesthetic, ketamine. Latter being the antagonist of NMDA receptors by activating glutamatergic transmission has antidepressant effects. One intravenous
infusion of 0.5 mg/kg of ketamine for 40 minutes can provide fast antidepressant effect, during the bipolar and monopolar resistant depression, especially with high risk of suicide. Instability
of antidepressant effect of ketamine from a few hours to several weeks is demonstrated. It is also proved the effectiveness of ketamine in obsessive-compulsive and posttraumatic frustration.
Intramuscular, oral and intranasal routes of applications are researched. Ketamin can probably serve as a therapeutic alternative in some patients with pharmacotherapy resistant depression
except patients with substance abuse or a history of psychosis. |
| first_indexed | 2024-12-17T12:23:57Z |
| format | Article |
| id | doaj.art-2f76f76f35f04c2a9ace4b1c6cc84187 |
| institution | Directory Open Access Journal |
| issn | 2306-4137 |
| language | English |
| last_indexed | 2024-12-17T12:23:57Z |
| publishDate | 2016-09-01 |
| publisher | Современная терапия психических расстройств |
| record_format | Article |
| series | Современная терапия психических расстройств |
| spelling | doaj.art-2f76f76f35f04c2a9ace4b1c6cc841872022-12-21T21:48:51ZengСовременная терапия психических расстройствСовременная терапия психических расстройств2306-41372016-09-0120163 (38)91510.21265/PSYPH.2016.38.355710.21265/PSYPH.2016.38.3557Ketamine: a new view on therapeutic opportunities in psychiatric practiceDorovskih, I.V.0Pavlova, T.A.1Scheidegger, J.M.2FGKI 1586-th clinical military hospital of the defense Ministry RFFGKI 1586-th clinical military hospital of the defense Ministry RFFGKI 1586Vth clinical military hospital of the defense Ministry RFThis article is a review of evidence-based research in English for the past 15 years thanks to access via a database PubMed and Medline, about the new features out of claimed indications of the well-known short--acting anesthetic, ketamine. Latter being the antagonist of NMDA receptors by activating glutamatergic transmission has antidepressant effects. One intravenous infusion of 0.5 mg/kg of ketamine for 40 minutes can provide fast antidepressant effect, during the bipolar and monopolar resistant depression, especially with high risk of suicide. Instability of antidepressant effect of ketamine from a few hours to several weeks is demonstrated. It is also proved the effectiveness of ketamine in obsessive-compulsive and posttraumatic frustration. Intramuscular, oral and intranasal routes of applications are researched. Ketamin can probably serve as a therapeutic alternative in some patients with pharmacotherapy resistant depression except patients with substance abuse or a history of psychosis.http://psypharma.ru/ru/ketamin-novyy-vzglyad-na-terapevticheskie-vozmozhnosti-v-psihiatricheskoy-praktikeкетаминглютаматергическая нейропередачатерапевтически резистентная депрессияобссесивно-компульсивное расстройствопосттравматическое расстройствоketamineglutamatergic neurotransmissiontherapy-resistant depressionobsessive-compulsive disorderpost-traumatic stress disorder |
| spellingShingle | Dorovskih, I.V. Pavlova, T.A. Scheidegger, J.M. Ketamine: a new view on therapeutic opportunities in psychiatric practice Современная терапия психических расстройств кетамин глютаматергическая нейропередача терапевтически резистентная депрессия обссесивно-компульсивное расстройство посттравматическое расстройство ketamine glutamatergic neurotransmission therapy-resistant depression obsessive-compulsive disorder post-traumatic stress disorder |
| title | Ketamine: a new view on therapeutic opportunities in psychiatric practice |
| title_full | Ketamine: a new view on therapeutic opportunities in psychiatric practice |
| title_fullStr | Ketamine: a new view on therapeutic opportunities in psychiatric practice |
| title_full_unstemmed | Ketamine: a new view on therapeutic opportunities in psychiatric practice |
| title_short | Ketamine: a new view on therapeutic opportunities in psychiatric practice |
| title_sort | ketamine a new view on therapeutic opportunities in psychiatric practice |
| topic | кетамин глютаматергическая нейропередача терапевтически резистентная депрессия обссесивно-компульсивное расстройство посттравматическое расстройство ketamine glutamatergic neurotransmission therapy-resistant depression obsessive-compulsive disorder post-traumatic stress disorder |
| url | http://psypharma.ru/ru/ketamin-novyy-vzglyad-na-terapevticheskie-vozmozhnosti-v-psihiatricheskoy-praktike |
| work_keys_str_mv | AT dorovskihiv ketamineanewviewontherapeuticopportunitiesinpsychiatricpractice AT pavlovata ketamineanewviewontherapeuticopportunitiesinpsychiatricpractice AT scheideggerjm ketamineanewviewontherapeuticopportunitiesinpsychiatricpractice |