Unravelling the functional development of vertebrate pathways controlling gaze
Animals constantly redirect their gaze away or towards relevant targets and, besides these goal-oriented responses, stabilizing movements clamp the visual scene avoiding image blurring. The vestibulo-ocular (VOR) and the optokinetic reflexes are the main contributors to gaze stabilization, whereas t...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-10-01
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| Series: | Frontiers in Cell and Developmental Biology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2023.1298486/full |
| _version_ | 1797648640604372992 |
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| author | Marta Barandela Carmen Núñez-González Daichi G. Suzuki Cecilia Jiménez-López Manuel A. Pombal Juan Pérez-Fernández Juan Pérez-Fernández |
| author_facet | Marta Barandela Carmen Núñez-González Daichi G. Suzuki Cecilia Jiménez-López Manuel A. Pombal Juan Pérez-Fernández Juan Pérez-Fernández |
| author_sort | Marta Barandela |
| collection | DOAJ |
| description | Animals constantly redirect their gaze away or towards relevant targets and, besides these goal-oriented responses, stabilizing movements clamp the visual scene avoiding image blurring. The vestibulo-ocular (VOR) and the optokinetic reflexes are the main contributors to gaze stabilization, whereas the optic tectum integrates multisensory information and generates orienting/evasive gaze movements in all vertebrates. Lampreys show a unique stepwise development of the visual system whose understanding provides important insights into the evolution and development of vertebrate vision. Although the developmental emergence of the visual components, and the retinofugal pathways have been described, the functional development of the visual system and the development of the downstream pathways controlling gaze are still unknown. Here, we show that VOR followed by light-evoked eye movements are the first to appear already in larvae, despite their burrowed lifestyle. However, the circuits controlling goal-oriented responses emerge later, in larvae in non-parasitic lampreys but during late metamorphosis in parasitic lampreys. The appearance of stabilizing responses earlier than goal-oriented in the lamprey development shows a stepwise transition from simpler to more complex visual systems, offering a unique opportunity to isolate the functioning of their underlying circuits. |
| first_indexed | 2024-03-11T15:33:53Z |
| format | Article |
| id | doaj.art-2f774634e9d4420f9a134276b06e46ee |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-03-11T15:33:53Z |
| publishDate | 2023-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-2f774634e9d4420f9a134276b06e46ee2023-10-26T23:39:24ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2023-10-011110.3389/fcell.2023.12984861298486Unravelling the functional development of vertebrate pathways controlling gazeMarta Barandela0Carmen Núñez-González1Daichi G. Suzuki2Cecilia Jiménez-López3Manuel A. Pombal4Juan Pérez-Fernández5Juan Pérez-Fernández6CINBIO, Universidade de Vigo, Neurocircuits Group, Campus universitario Lagoas, Marcosende, Vigo, SpainCINBIO, Universidade de Vigo, Neurocircuits Group, Campus universitario Lagoas, Marcosende, Vigo, SpainFaculty of Life and Environmental Sciences, University of Tsukuba, Tsukuba, JapanCINBIO, Universidade de Vigo, Neurocircuits Group, Campus universitario Lagoas, Marcosende, Vigo, SpainDepartment of Functional Biology and Health Sciences, Facultade de Bioloxía-IBIV, Universidade de Vigo, Campus universitario Lagoas, Marcosende, Vigo, SpainCINBIO, Universidade de Vigo, Neurocircuits Group, Campus universitario Lagoas, Marcosende, Vigo, SpainDepartment of Functional Biology and Health Sciences, Facultade de Bioloxía-IBIV, Universidade de Vigo, Campus universitario Lagoas, Marcosende, Vigo, SpainAnimals constantly redirect their gaze away or towards relevant targets and, besides these goal-oriented responses, stabilizing movements clamp the visual scene avoiding image blurring. The vestibulo-ocular (VOR) and the optokinetic reflexes are the main contributors to gaze stabilization, whereas the optic tectum integrates multisensory information and generates orienting/evasive gaze movements in all vertebrates. Lampreys show a unique stepwise development of the visual system whose understanding provides important insights into the evolution and development of vertebrate vision. Although the developmental emergence of the visual components, and the retinofugal pathways have been described, the functional development of the visual system and the development of the downstream pathways controlling gaze are still unknown. Here, we show that VOR followed by light-evoked eye movements are the first to appear already in larvae, despite their burrowed lifestyle. However, the circuits controlling goal-oriented responses emerge later, in larvae in non-parasitic lampreys but during late metamorphosis in parasitic lampreys. The appearance of stabilizing responses earlier than goal-oriented in the lamprey development shows a stepwise transition from simpler to more complex visual systems, offering a unique opportunity to isolate the functioning of their underlying circuits.https://www.frontiersin.org/articles/10.3389/fcell.2023.1298486/fullvisual systemeye movementsvestibulo-ocular reflexoptokinetic reflexpretectumoptic tectum |
| spellingShingle | Marta Barandela Carmen Núñez-González Daichi G. Suzuki Cecilia Jiménez-López Manuel A. Pombal Juan Pérez-Fernández Juan Pérez-Fernández Unravelling the functional development of vertebrate pathways controlling gaze Frontiers in Cell and Developmental Biology visual system eye movements vestibulo-ocular reflex optokinetic reflex pretectum optic tectum |
| title | Unravelling the functional development of vertebrate pathways controlling gaze |
| title_full | Unravelling the functional development of vertebrate pathways controlling gaze |
| title_fullStr | Unravelling the functional development of vertebrate pathways controlling gaze |
| title_full_unstemmed | Unravelling the functional development of vertebrate pathways controlling gaze |
| title_short | Unravelling the functional development of vertebrate pathways controlling gaze |
| title_sort | unravelling the functional development of vertebrate pathways controlling gaze |
| topic | visual system eye movements vestibulo-ocular reflex optokinetic reflex pretectum optic tectum |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2023.1298486/full |
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