Single and multiple dose Fluconazole in the treatment of candidia vulvovaginitis: a prospective comparative study
 Background: Vulvovaginal candidiasis, the most common type of vaginitis, is usually caused by Candidia albicans. Patients experience a variety of symptoms. There are many types of vulvovaginal candidiasis with various microbial causes, symptoms, host circumstances, recurrence rates, an...
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| Format: | Article |
| Language: | fas |
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Tehran University of Medical Sciences
2007-09-01
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| Series: | Tehran University Medical Journal |
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| Online Access: | http://journals.tums.ac.ir/PdfMed.aspx?pdf_med=/upload_files/pdf/3787.pdf&manuscript_id=3787 |
| _version_ | 1818410373136515072 |
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| author | Ashrafinia M Behdani R Komijani Z |
| author_facet | Ashrafinia M Behdani R Komijani Z |
| author_sort | Ashrafinia M |
| collection | DOAJ |
| description |  Background: Vulvovaginal candidiasis, the most common type of vaginitis, is usually caused by Candidia albicans. Patients experience a variety of symptoms. There are many types of vulvovaginal candidiasis with various microbial causes, symptoms, host circumstances, recurrence rates, and responses to treatment. The purpose of this study was to find the best method of treatment of complicated vaginitis as determined by its high prevalence, varying symptoms and signs and patient complaints.Methods: In this open clinical trial without placebo control, we studied all patients aged 18 to 65 years, suffering from vaginitis symptoms that presented at the gynecological clinic of Arash Hospital, Tehran, Iran, during the year 2004. After obtaining informed consent, we assessed the response to a treatment of single 150 mg dose of fluconazole in one group, and sequential 150 mg doses of fluconazole in the other. The analysis was performed using SPSS statistical software (version 11).Results: With regard to symptom severity, no significant difference was found between the groups. The rate of excoriation and fissure formation demonstrated significant difference between the two groups (p=0.048). Assessment of clinical and mycological response proved that patients with severe vaginitis treated with sequential doses of fluconazole had a better general status than those in the other group. The difference between the severity of vaginitis and positive response to the treatment in culture was not significant among patients with recurrent vaginitis.Conclusion: Patients with mild to moderate recurrent vaginitis show better response to treatment. The high rate of positive culture on day 35 reconfirms the limitation of fluconazole and other azoles as fungistatic drugs. |
| first_indexed | 2024-12-14T10:14:29Z |
| format | Article |
| id | doaj.art-2f776bda9eac424b8d7dc7cdd876320c |
| institution | Directory Open Access Journal |
| issn | 1683-1764 1735-7322 |
| language | fas |
| last_indexed | 2024-12-14T10:14:29Z |
| publishDate | 2007-09-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | Tehran University Medical Journal |
| spelling | doaj.art-2f776bda9eac424b8d7dc7cdd876320c2022-12-21T23:06:55ZfasTehran University of Medical SciencesTehran University Medical Journal1683-17641735-73222007-09-016551925Single and multiple dose Fluconazole in the treatment of candidia vulvovaginitis: a prospective comparative studyAshrafinia MBehdani RKomijani Z Background: Vulvovaginal candidiasis, the most common type of vaginitis, is usually caused by Candidia albicans. Patients experience a variety of symptoms. There are many types of vulvovaginal candidiasis with various microbial causes, symptoms, host circumstances, recurrence rates, and responses to treatment. The purpose of this study was to find the best method of treatment of complicated vaginitis as determined by its high prevalence, varying symptoms and signs and patient complaints.Methods: In this open clinical trial without placebo control, we studied all patients aged 18 to 65 years, suffering from vaginitis symptoms that presented at the gynecological clinic of Arash Hospital, Tehran, Iran, during the year 2004. After obtaining informed consent, we assessed the response to a treatment of single 150 mg dose of fluconazole in one group, and sequential 150 mg doses of fluconazole in the other. The analysis was performed using SPSS statistical software (version 11).Results: With regard to symptom severity, no significant difference was found between the groups. The rate of excoriation and fissure formation demonstrated significant difference between the two groups (p=0.048). Assessment of clinical and mycological response proved that patients with severe vaginitis treated with sequential doses of fluconazole had a better general status than those in the other group. The difference between the severity of vaginitis and positive response to the treatment in culture was not significant among patients with recurrent vaginitis.Conclusion: Patients with mild to moderate recurrent vaginitis show better response to treatment. The high rate of positive culture on day 35 reconfirms the limitation of fluconazole and other azoles as fungistatic drugs.http://journals.tums.ac.ir/PdfMed.aspx?pdf_med=/upload_files/pdf/3787.pdf&manuscript_id=3787Vulvovaginal candidiasisfluconazole |
| spellingShingle | Ashrafinia M Behdani R Komijani Z Single and multiple dose Fluconazole in the treatment of candidia vulvovaginitis: a prospective comparative study Tehran University Medical Journal Vulvovaginal candidiasis fluconazole |
| title | Single and multiple dose Fluconazole in the treatment of candidia vulvovaginitis: a prospective comparative study |
| title_full | Single and multiple dose Fluconazole in the treatment of candidia vulvovaginitis: a prospective comparative study |
| title_fullStr | Single and multiple dose Fluconazole in the treatment of candidia vulvovaginitis: a prospective comparative study |
| title_full_unstemmed | Single and multiple dose Fluconazole in the treatment of candidia vulvovaginitis: a prospective comparative study |
| title_short | Single and multiple dose Fluconazole in the treatment of candidia vulvovaginitis: a prospective comparative study |
| title_sort | single and multiple dose fluconazole in the treatment of candidia vulvovaginitis a prospective comparative study |
| topic | Vulvovaginal candidiasis fluconazole |
| url | http://journals.tums.ac.ir/PdfMed.aspx?pdf_med=/upload_files/pdf/3787.pdf&manuscript_id=3787 |
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