P-66 CARDIOVASCULAR RISK PROFILE AND ATHEROSCLEROSIS IN PATIENTS WITH NON-ALCOHOLIC FATTY LIVER DISEASE
Introduction and Objectives: Non-alcoholic fatty liver disease (NAFLD) is a frequent cause of liver disease, with a worldwide prevalence of 25%. There seems to be a connection between the gravity of NAFLD, atherosclerosis, and the increase in cardiovascular events and mortality. This study aimed to...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-03-01
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| Series: | Annals of Hepatology |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1665268123000686 |
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| author | Maria Eduarda de Almeida Oliveira Sérgio Augusto Antônio Davi Cassiano Costa Raphael Carreiro Moura Daniele Araújo de Azeredo Coutinho Carlos Roberto de Andrade Junior Maria Auxiliadora Saad Priscila Pollo Flores Débora Vieira Soares |
| author_facet | Maria Eduarda de Almeida Oliveira Sérgio Augusto Antônio Davi Cassiano Costa Raphael Carreiro Moura Daniele Araújo de Azeredo Coutinho Carlos Roberto de Andrade Junior Maria Auxiliadora Saad Priscila Pollo Flores Débora Vieira Soares |
| author_sort | Maria Eduarda de Almeida Oliveira |
| collection | DOAJ |
| description | Introduction and Objectives: Non-alcoholic fatty liver disease (NAFLD) is a frequent cause of liver disease, with a worldwide prevalence of 25%. There seems to be a connection between the gravity of NAFLD, atherosclerosis, and the increase in cardiovascular events and mortality. This study aimed to assess the cardiovascular risk profile and subclinical atherosclerosis of individuals with NAFLD. Materials and Methods: Prospective observational analytical study. Adults with an established risk for the development of NAFLD were selected, such: as type 2 Diabetes Mellitus (T2DM), obesity or overweight, and/or altered alanine aminotransferase. Non-invasive assessment of liver steatosis and fibrosis was performed by hepatic ultrasound (US) and transient elastography. We evaluated the frequency of the cardiovascular disease, according to the clinical history and common carotid artery intima-media thickness (IMT), using an ultrasound examination of the carotids. Results: All data are presented in median (IQR) or n(%). Forty-three participants were enrolled, female 34(79%), chronological age 62.5(54-67.2)years. Comorbidities: Systemic Arterial Hypertension 30(69.7%), T2DM 22(51.1%), Obesity 19(44.1%) and Dyslipidemia 22(55,8%). Only one was a smoker. Carotids-US: vascular age 65(62-83) years, right cIMT 0.65(0.54-0.8)mm and left cIMT 0.65(0.54-0.76)mm, atherosclerotic plaques were present in 11(25,5%) participants. Hepatic Steatosis were observed in 37(86.1%) classified according to the US-FLI score as: mild 8(21.6%), moderate 19(51.3%) and severe 10(27.1%). Liver Fibrosis (F ≥2) were observed in 11(29.7%), among them 4(36.3%) had atherosclerotic plaques. Conclusions: The data suggest a high frequency of atherosclerosis, demonstrated by the presence of atherosclerotic plaques in the carotid arteries in patients with hepatic fibrosis. |
| first_indexed | 2024-04-09T22:15:56Z |
| format | Article |
| id | doaj.art-2f77a555b3154711a836decd782dd57e |
| institution | Directory Open Access Journal |
| issn | 1665-2681 |
| language | English |
| last_indexed | 2024-04-09T22:15:56Z |
| publishDate | 2023-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Annals of Hepatology |
| spelling | doaj.art-2f77a555b3154711a836decd782dd57e2023-03-23T04:34:11ZengElsevierAnnals of Hepatology1665-26812023-03-0128100964P-66 CARDIOVASCULAR RISK PROFILE AND ATHEROSCLEROSIS IN PATIENTS WITH NON-ALCOHOLIC FATTY LIVER DISEASEMaria Eduarda de Almeida Oliveira0Sérgio Augusto Antônio1Davi Cassiano Costa2Raphael Carreiro Moura3Daniele Araújo de Azeredo Coutinho4Carlos Roberto de Andrade Junior5Maria Auxiliadora Saad6Priscila Pollo Flores7Débora Vieira Soares8Department of Clinical Medicine, Faculty of Medicine, Fluminense Federal University -UFF, Rio de Janeiro, BrazilDepartment of Clinical Medicine, Faculty of Medicine, Fluminense Federal University -UFF, Rio de Janeiro, BrazilDepartment of Clinical Medicine, Faculty of Medicine, Fluminense Federal University -UFF, Rio de Janeiro, BrazilDepartment of Clinical Medicine, Faculty of Medicine, Fluminense Federal University -UFF, Rio de Janeiro, BrazilDepartment of Clinical Medicine, Faculty of Medicine, Fluminense Federal University -UFF, Rio de Janeiro, BrazilDepartment of Clinical Medicine, Faculty of Medicine, Fluminense Federal University -UFF, Rio de Janeiro, BrazilDepartment of Clinical Medicine, Faculty of Medicine, Fluminense Federal University -UFF, Rio de Janeiro, BrazilDepartment of Clinical Medicine, Faculty of Medicine, Fluminense Federal University -UFF, Rio de Janeiro, BrazilDepartment of Clinical Medicine, Faculty of Medicine, Fluminense Federal University -UFF, Rio de Janeiro, BrazilIntroduction and Objectives: Non-alcoholic fatty liver disease (NAFLD) is a frequent cause of liver disease, with a worldwide prevalence of 25%. There seems to be a connection between the gravity of NAFLD, atherosclerosis, and the increase in cardiovascular events and mortality. This study aimed to assess the cardiovascular risk profile and subclinical atherosclerosis of individuals with NAFLD. Materials and Methods: Prospective observational analytical study. Adults with an established risk for the development of NAFLD were selected, such: as type 2 Diabetes Mellitus (T2DM), obesity or overweight, and/or altered alanine aminotransferase. Non-invasive assessment of liver steatosis and fibrosis was performed by hepatic ultrasound (US) and transient elastography. We evaluated the frequency of the cardiovascular disease, according to the clinical history and common carotid artery intima-media thickness (IMT), using an ultrasound examination of the carotids. Results: All data are presented in median (IQR) or n(%). Forty-three participants were enrolled, female 34(79%), chronological age 62.5(54-67.2)years. Comorbidities: Systemic Arterial Hypertension 30(69.7%), T2DM 22(51.1%), Obesity 19(44.1%) and Dyslipidemia 22(55,8%). Only one was a smoker. Carotids-US: vascular age 65(62-83) years, right cIMT 0.65(0.54-0.8)mm and left cIMT 0.65(0.54-0.76)mm, atherosclerotic plaques were present in 11(25,5%) participants. Hepatic Steatosis were observed in 37(86.1%) classified according to the US-FLI score as: mild 8(21.6%), moderate 19(51.3%) and severe 10(27.1%). Liver Fibrosis (F ≥2) were observed in 11(29.7%), among them 4(36.3%) had atherosclerotic plaques. Conclusions: The data suggest a high frequency of atherosclerosis, demonstrated by the presence of atherosclerotic plaques in the carotid arteries in patients with hepatic fibrosis.http://www.sciencedirect.com/science/article/pii/S1665268123000686 |
| spellingShingle | Maria Eduarda de Almeida Oliveira Sérgio Augusto Antônio Davi Cassiano Costa Raphael Carreiro Moura Daniele Araújo de Azeredo Coutinho Carlos Roberto de Andrade Junior Maria Auxiliadora Saad Priscila Pollo Flores Débora Vieira Soares P-66 CARDIOVASCULAR RISK PROFILE AND ATHEROSCLEROSIS IN PATIENTS WITH NON-ALCOHOLIC FATTY LIVER DISEASE Annals of Hepatology |
| title | P-66 CARDIOVASCULAR RISK PROFILE AND ATHEROSCLEROSIS IN PATIENTS WITH NON-ALCOHOLIC FATTY LIVER DISEASE |
| title_full | P-66 CARDIOVASCULAR RISK PROFILE AND ATHEROSCLEROSIS IN PATIENTS WITH NON-ALCOHOLIC FATTY LIVER DISEASE |
| title_fullStr | P-66 CARDIOVASCULAR RISK PROFILE AND ATHEROSCLEROSIS IN PATIENTS WITH NON-ALCOHOLIC FATTY LIVER DISEASE |
| title_full_unstemmed | P-66 CARDIOVASCULAR RISK PROFILE AND ATHEROSCLEROSIS IN PATIENTS WITH NON-ALCOHOLIC FATTY LIVER DISEASE |
| title_short | P-66 CARDIOVASCULAR RISK PROFILE AND ATHEROSCLEROSIS IN PATIENTS WITH NON-ALCOHOLIC FATTY LIVER DISEASE |
| title_sort | p 66 cardiovascular risk profile and atherosclerosis in patients with non alcoholic fatty liver disease |
| url | http://www.sciencedirect.com/science/article/pii/S1665268123000686 |
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