Pharmacological Potential of Flavonoids against Neurotropic Viruses
Flavonoids are a group of natural compounds that have been described in the literature as having anti-inflammatory, antioxidant, and neuroprotective compounds. Although they are considered versatile molecules, little has been discussed about their antiviral activities for neurotropic viruses. Hence,...
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MDPI AG
2022-09-01
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| author | Juliana Helena Castro e Silva Jéssica Teles Souza Clarissa Schitine Aníbal de Freitas Santos Júnior Eduardo Muniz Santana Bastos Silvia Lima Costa |
| author_facet | Juliana Helena Castro e Silva Jéssica Teles Souza Clarissa Schitine Aníbal de Freitas Santos Júnior Eduardo Muniz Santana Bastos Silvia Lima Costa |
| author_sort | Juliana Helena Castro e Silva |
| collection | DOAJ |
| description | Flavonoids are a group of natural compounds that have been described in the literature as having anti-inflammatory, antioxidant, and neuroprotective compounds. Although they are considered versatile molecules, little has been discussed about their antiviral activities for neurotropic viruses. Hence, the present study aimed to investigate the pharmacological potential of flavonoids in the face of viruses that can affect the central nervous system (CNS). We carried out research from 2011 to 2021 using the Pubmed platform. The following were excluded: articles not in the English language, letters to editors, review articles and papers that did not include any experimental or clinical tests, and papers that showed antiviral activities against viruses that do not infect human beings. The inclusion criteria were in silico predictions and preclinical pharmacological studies, in vitro, in vivo and ex vivo, and clinical studies with flavonoids, flavonoid fractions and extracts that were active against neurotropic viruses. The search resulted in 205 articles that were sorted per virus type and discussed, considering the most cited antiviral activities. Our investigation shows the latest relevant data about flavonoids that have presented a wide range of actions against viruses that affect the CNS, mainly influenza, hepatitis C and others, such as the coronavirus, enterovirus, and arbovirus. Considering that these molecules present well-known anti-inflammatory and neuroprotective activities, using flavonoids that have demonstrated both neuroprotective and antiviral effects could be viewed as an alternative for therapy in the course of CNS infections. |
| first_indexed | 2024-03-09T22:51:06Z |
| format | Article |
| id | doaj.art-2f77ed91ea2444408cfa71e64ef1bfbe |
| institution | Directory Open Access Journal |
| issn | 1424-8247 |
| language | English |
| last_indexed | 2024-03-09T22:51:06Z |
| publishDate | 2022-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceuticals |
| spelling | doaj.art-2f77ed91ea2444408cfa71e64ef1bfbe2023-11-23T18:19:35ZengMDPI AGPharmaceuticals1424-82472022-09-01159114910.3390/ph15091149Pharmacological Potential of Flavonoids against Neurotropic VirusesJuliana Helena Castro e Silva0Jéssica Teles Souza1Clarissa Schitine2Aníbal de Freitas Santos Júnior3Eduardo Muniz Santana Bastos4Silvia Lima Costa5Department of Biochemistry and Biophysics, Health Sciences Institute, Federal University of Bahia, Salvador 40110-100, BrazilDepartment of Biochemistry and Biophysics, Health Sciences Institute, Federal University of Bahia, Salvador 40110-100, BrazilDepartment of Biochemistry and Biophysics, Health Sciences Institute, Federal University of Bahia, Salvador 40110-100, BrazilDepartment of Life Sciences, State University of Bahia, Salvador 41150-000, BrazilDepartment of Biochemistry and Biophysics, Health Sciences Institute, Federal University of Bahia, Salvador 40110-100, BrazilDepartment of Biochemistry and Biophysics, Health Sciences Institute, Federal University of Bahia, Salvador 40110-100, BrazilFlavonoids are a group of natural compounds that have been described in the literature as having anti-inflammatory, antioxidant, and neuroprotective compounds. Although they are considered versatile molecules, little has been discussed about their antiviral activities for neurotropic viruses. Hence, the present study aimed to investigate the pharmacological potential of flavonoids in the face of viruses that can affect the central nervous system (CNS). We carried out research from 2011 to 2021 using the Pubmed platform. The following were excluded: articles not in the English language, letters to editors, review articles and papers that did not include any experimental or clinical tests, and papers that showed antiviral activities against viruses that do not infect human beings. The inclusion criteria were in silico predictions and preclinical pharmacological studies, in vitro, in vivo and ex vivo, and clinical studies with flavonoids, flavonoid fractions and extracts that were active against neurotropic viruses. The search resulted in 205 articles that were sorted per virus type and discussed, considering the most cited antiviral activities. Our investigation shows the latest relevant data about flavonoids that have presented a wide range of actions against viruses that affect the CNS, mainly influenza, hepatitis C and others, such as the coronavirus, enterovirus, and arbovirus. Considering that these molecules present well-known anti-inflammatory and neuroprotective activities, using flavonoids that have demonstrated both neuroprotective and antiviral effects could be viewed as an alternative for therapy in the course of CNS infections.https://www.mdpi.com/1424-8247/15/9/1149flavonoidantiviralcentral nervous system infection |
| spellingShingle | Juliana Helena Castro e Silva Jéssica Teles Souza Clarissa Schitine Aníbal de Freitas Santos Júnior Eduardo Muniz Santana Bastos Silvia Lima Costa Pharmacological Potential of Flavonoids against Neurotropic Viruses Pharmaceuticals flavonoid antiviral central nervous system infection |
| title | Pharmacological Potential of Flavonoids against Neurotropic Viruses |
| title_full | Pharmacological Potential of Flavonoids against Neurotropic Viruses |
| title_fullStr | Pharmacological Potential of Flavonoids against Neurotropic Viruses |
| title_full_unstemmed | Pharmacological Potential of Flavonoids against Neurotropic Viruses |
| title_short | Pharmacological Potential of Flavonoids against Neurotropic Viruses |
| title_sort | pharmacological potential of flavonoids against neurotropic viruses |
| topic | flavonoid antiviral central nervous system infection |
| url | https://www.mdpi.com/1424-8247/15/9/1149 |
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