Metastatic lymph node burden impacts overall survival in submandibular gland cancer
ObjectiveTo assess the effect of the number of positive lymph nodes (LNs) on the overall survival (OS) of patients with submandibular gland cancer (SmGC).MethodsPatients who had undergone neck dissection for SmGC were retrospectively enrolled in this study. The effect of the American Joint Committee...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-11-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2023.1229493/full |
| _version_ | 1797628008027127808 |
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| author | Lei Wang Lei Wang Weihong Shi Weihong Shi |
| author_facet | Lei Wang Lei Wang Weihong Shi Weihong Shi |
| author_sort | Lei Wang |
| collection | DOAJ |
| description | ObjectiveTo assess the effect of the number of positive lymph nodes (LNs) on the overall survival (OS) of patients with submandibular gland cancer (SmGC).MethodsPatients who had undergone neck dissection for SmGC were retrospectively enrolled in this study. The effect of the American Joint Committee on Cancer (AJCC) N stage, the number of positive LNs, LN size, LN ratio, and extranodal extension (ENE) on OS and recurrence-free survival (RFS) was evaluated using Cox analysis. Prognostic models were proposed based on the identified significant variable, and their performance was compared using hazard consistency and discrimination.ResultsIn total, 129 patients were included in this study. The number of positive LNs rather than LN ratio, LN size, and ENE was associated with OS. A prognostic model based on the number of positive LNs (0 vs. 1–2 vs. 3+) demonstrated a higher likelihood ratio and Harrell’s C index than those according to the 7th/8th edition of the AJCC N stage in predicting OS and RFS.ConclusionsThe effect of LN metastasis on OS and RFS was mainly determined by the number of positive LNs. A validation of this finding is warranted in adenoid cystic carcinomas that were not included in this study. |
| first_indexed | 2024-03-11T10:32:26Z |
| format | Article |
| id | doaj.art-2f78b0f20a0c4e079c46243c0caa3559 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-03-11T10:32:26Z |
| publishDate | 2023-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-2f78b0f20a0c4e079c46243c0caa35592023-11-14T13:44:01ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2023-11-011310.3389/fonc.2023.12294931229493Metastatic lymph node burden impacts overall survival in submandibular gland cancerLei Wang0Lei Wang1Weihong Shi2Weihong Shi3Department of Stomatology, The Third Affiliated Hospital of Xinxiang Medical University, Xinxiang, ChinaDepartment of Oral Medicine, School of Stomatology, Xinxiang Medical University, Xinxiang, ChinaDepartment of Stomatology, The Third Affiliated Hospital of Xinxiang Medical University, Xinxiang, ChinaDepartment of Oral Medicine, School of Stomatology, Xinxiang Medical University, Xinxiang, ChinaObjectiveTo assess the effect of the number of positive lymph nodes (LNs) on the overall survival (OS) of patients with submandibular gland cancer (SmGC).MethodsPatients who had undergone neck dissection for SmGC were retrospectively enrolled in this study. The effect of the American Joint Committee on Cancer (AJCC) N stage, the number of positive LNs, LN size, LN ratio, and extranodal extension (ENE) on OS and recurrence-free survival (RFS) was evaluated using Cox analysis. Prognostic models were proposed based on the identified significant variable, and their performance was compared using hazard consistency and discrimination.ResultsIn total, 129 patients were included in this study. The number of positive LNs rather than LN ratio, LN size, and ENE was associated with OS. A prognostic model based on the number of positive LNs (0 vs. 1–2 vs. 3+) demonstrated a higher likelihood ratio and Harrell’s C index than those according to the 7th/8th edition of the AJCC N stage in predicting OS and RFS.ConclusionsThe effect of LN metastasis on OS and RFS was mainly determined by the number of positive LNs. A validation of this finding is warranted in adenoid cystic carcinomas that were not included in this study.https://www.frontiersin.org/articles/10.3389/fonc.2023.1229493/fullsubmandibular gland canceroverall survivalAJCC stagelymph node metastasisnumber of positive lymph nodes |
| spellingShingle | Lei Wang Lei Wang Weihong Shi Weihong Shi Metastatic lymph node burden impacts overall survival in submandibular gland cancer Frontiers in Oncology submandibular gland cancer overall survival AJCC stage lymph node metastasis number of positive lymph nodes |
| title | Metastatic lymph node burden impacts overall survival in submandibular gland cancer |
| title_full | Metastatic lymph node burden impacts overall survival in submandibular gland cancer |
| title_fullStr | Metastatic lymph node burden impacts overall survival in submandibular gland cancer |
| title_full_unstemmed | Metastatic lymph node burden impacts overall survival in submandibular gland cancer |
| title_short | Metastatic lymph node burden impacts overall survival in submandibular gland cancer |
| title_sort | metastatic lymph node burden impacts overall survival in submandibular gland cancer |
| topic | submandibular gland cancer overall survival AJCC stage lymph node metastasis number of positive lymph nodes |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2023.1229493/full |
| work_keys_str_mv | AT leiwang metastaticlymphnodeburdenimpactsoverallsurvivalinsubmandibularglandcancer AT leiwang metastaticlymphnodeburdenimpactsoverallsurvivalinsubmandibularglandcancer AT weihongshi metastaticlymphnodeburdenimpactsoverallsurvivalinsubmandibularglandcancer AT weihongshi metastaticlymphnodeburdenimpactsoverallsurvivalinsubmandibularglandcancer |