Higher critical closing pressure is independently associated with enlarged basal ganglia perivascular spaces
ObjectiveThis study aimed to explore the association between cerebral hemodynamic parameters focused on the critical closing pressure (CCP) and enlarged perivascular spaces (EPVS).MethodsCerebral blood velocity in the middle cerebral artery (MCAv) and non-invasive continuous blood pressure (NIBP) we...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-10-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2023.1165469/full |
| _version_ | 1797656965584781312 |
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| author | Jiayi Zhong Wanrong Lin Junru Chen Qingchun Gao |
| author_facet | Jiayi Zhong Wanrong Lin Junru Chen Qingchun Gao |
| author_sort | Jiayi Zhong |
| collection | DOAJ |
| description | ObjectiveThis study aimed to explore the association between cerebral hemodynamic parameters focused on the critical closing pressure (CCP) and enlarged perivascular spaces (EPVS).MethodsCerebral blood velocity in the middle cerebral artery (MCAv) and non-invasive continuous blood pressure (NIBP) were measured using a transcranial Doppler (TCD) and Finometer, followed by the calculation of cerebral hemodynamic parameters including CCP, resistance area product (RAP), pulsatility index (PI), and pulse pressure (PP). EPVS were graded separately in the basal ganglia (BG) and centrum semiovale (CSO), using a visual semiquantitative ordinal scale. Patients with EPVS >10 were classified into the severe BG-EPVS group and severe CSO-EPVS group, and the remainder into the mild BG-EPVS group and the mild CSO-EPVS group. Spearman’s correlation and binary logistic regression analysis were performed to analyze the relationship between hemodynamic parameters and BG-EPVS and CSO-EPVS, respectively.ResultsOverall, 107 patients were enrolled. The severe BG-EPVS group had higher CCP, mean arterial blood pressure (MABP), systolic blood pressure (SBP), and diastolic blood pressure (DBP) than that in the mild BG-EPVS group (p < 0.05). There was no statistical difference in hemodynamic parameters between the severe CSO-EPVS group and the mild CSO-EPVS group. Spearman’s correlation analysis showed that CCP was positively associated with BG-EPVS (rho = 0.331, p < 0.001) and CSO-EPVS (rho = 0.154, p = 0.044). The binary logistic regression analysis showed that CCP was independently associated with severe BG-EPVS (p < 0.05) and not with CSO-EPVS (p > 0.05) after adjusting for confounders.ConclusionCCP representing cerebrovascular tension was independently associated with BG-EPVS. |
| first_indexed | 2024-03-11T17:37:36Z |
| format | Article |
| id | doaj.art-2f79d42b1496437f8e042b52be1ec065 |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-03-11T17:37:36Z |
| publishDate | 2023-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-2f79d42b1496437f8e042b52be1ec0652023-10-18T18:08:02ZengFrontiers Media S.A.Frontiers in Neurology1664-22952023-10-011410.3389/fneur.2023.11654691165469Higher critical closing pressure is independently associated with enlarged basal ganglia perivascular spacesJiayi ZhongWanrong LinJunru ChenQingchun GaoObjectiveThis study aimed to explore the association between cerebral hemodynamic parameters focused on the critical closing pressure (CCP) and enlarged perivascular spaces (EPVS).MethodsCerebral blood velocity in the middle cerebral artery (MCAv) and non-invasive continuous blood pressure (NIBP) were measured using a transcranial Doppler (TCD) and Finometer, followed by the calculation of cerebral hemodynamic parameters including CCP, resistance area product (RAP), pulsatility index (PI), and pulse pressure (PP). EPVS were graded separately in the basal ganglia (BG) and centrum semiovale (CSO), using a visual semiquantitative ordinal scale. Patients with EPVS >10 were classified into the severe BG-EPVS group and severe CSO-EPVS group, and the remainder into the mild BG-EPVS group and the mild CSO-EPVS group. Spearman’s correlation and binary logistic regression analysis were performed to analyze the relationship between hemodynamic parameters and BG-EPVS and CSO-EPVS, respectively.ResultsOverall, 107 patients were enrolled. The severe BG-EPVS group had higher CCP, mean arterial blood pressure (MABP), systolic blood pressure (SBP), and diastolic blood pressure (DBP) than that in the mild BG-EPVS group (p < 0.05). There was no statistical difference in hemodynamic parameters between the severe CSO-EPVS group and the mild CSO-EPVS group. Spearman’s correlation analysis showed that CCP was positively associated with BG-EPVS (rho = 0.331, p < 0.001) and CSO-EPVS (rho = 0.154, p = 0.044). The binary logistic regression analysis showed that CCP was independently associated with severe BG-EPVS (p < 0.05) and not with CSO-EPVS (p > 0.05) after adjusting for confounders.ConclusionCCP representing cerebrovascular tension was independently associated with BG-EPVS.https://www.frontiersin.org/articles/10.3389/fneur.2023.1165469/fullcerebral small vessel diseasesenlarged perivascular spacescritical closing pressurecerebral autoregulationcerebral hemodynamic |
| spellingShingle | Jiayi Zhong Wanrong Lin Junru Chen Qingchun Gao Higher critical closing pressure is independently associated with enlarged basal ganglia perivascular spaces Frontiers in Neurology cerebral small vessel diseases enlarged perivascular spaces critical closing pressure cerebral autoregulation cerebral hemodynamic |
| title | Higher critical closing pressure is independently associated with enlarged basal ganglia perivascular spaces |
| title_full | Higher critical closing pressure is independently associated with enlarged basal ganglia perivascular spaces |
| title_fullStr | Higher critical closing pressure is independently associated with enlarged basal ganglia perivascular spaces |
| title_full_unstemmed | Higher critical closing pressure is independently associated with enlarged basal ganglia perivascular spaces |
| title_short | Higher critical closing pressure is independently associated with enlarged basal ganglia perivascular spaces |
| title_sort | higher critical closing pressure is independently associated with enlarged basal ganglia perivascular spaces |
| topic | cerebral small vessel diseases enlarged perivascular spaces critical closing pressure cerebral autoregulation cerebral hemodynamic |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2023.1165469/full |
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